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SPIRES-BOOKS: FIND KEYWORD GENE EXPRESSION *END*INIT* use /tmp/qspiwww.webspi1/17950.8 QRY 131.225.70.96 . find keyword gene expression ( in books using www Cover
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Call number:0471226165:ONLINE Show nearby items on shelf
Title:Analyzing Microarray Gene Expression Data
Author(s): McLachlan
Date:2004
Publisher:Wiley-Interscience
Size:1 online resource (353 p.)
ISBN:9780471226161
Series:eBooks
Series:Wiley Online Library
Series:Wiley 2016 package purchase
Keywords: Statistics
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Call number:0470517662:ONLINE Show nearby items on shelf
Title:Bayesian Analysis of Gene Expression Data
Author(s): Mallick
Date:2009
Publisher:Wiley
Size:1 online resource (253 p.)
ISBN:9780470517666
Series:eBooks
Series:Wiley Online Library
Series:Wiley 2016 package purchase
Keywords: Statistics
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Call number:0470163739:ONLINE Show nearby items on shelf
Title:Data Mining for Genomics and Proteomics: Analysisof Gene and Protein Expression Data
Author(s): Dziuda
Date:2010
Publisher:Wiley-Interscience
Size:1 online resource (329 p.)
ISBN:9780470163733
Series:eBooks
Series:Wiley Online Library
Series:Wiley 2016 package purchase
Keywords: Computer Science
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Call number:SPRINGER-2014-9783319066899:ONLINE Show nearby items on shelf
Title:Chemical Kinetics, Stochastic Processes, and Irreversible Thermodynamics [electronic resource]
Author(s): Moiss Santilln
Date:2014
Publisher:Cham : Springer International Publishing : Imprint: Springer
Size:1 online resource
Note:This book brings theories in nonlinear dynamics, stochastic processes, irreversible thermodynamics, physical chemistry, and biochemistry together in an introductory but formal and comprehensive manner. Coupled with examples, thetheories are developed stepwise, starting with the simplest concepts and building upon them into a more general framework. Furthermore, each new mathematical derivation is immediately applied to one or more biological systems. Thelast chapters focus on applying mathematical an d physical techniques to study systems such as: gene regulatory networks and ion channels. The target audience of this book are mainly final year undergraduate and graduate students with asolid mathematical background (physicists, mathematicians, and engi neers), as well as with basic notions of biochemistry and cellular biology. This book can also be useful to students with a biological background who are interestedin mathematical modeling, and have a working knowledge of calculus, differential equations, and a basic understanding of probability theory
Contents:Brief Introduction to Chemical Kinetics
Brief Introduction to Thermodynamics
Different Approaches to Analyzing a Simple Chemical Reaction
Molecule Synthesis and Degradation
Enzymatic Reactions
Receltor
Ligand Interaction
Cooperativity
Gene Expression and Regulation
Ion Channel Dynamics and Ion Transport Across Memberanes
References
Index
ISBN:9783319066899
Series:eBooks
Series:SpringerLink
Series:Lecture Notes on Mathematical Modelling in the Life Sciences, 2193-4789
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Chemistry Mathematics , Distribution (Probability theory)
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Call number:SPRINGER-2012-9780817648015:ONLINE Show nearby items on shelf
Title:Parametric Statistical Change Point Analysis [electronic resource] : With Applications to Genetics, Medicine, and Finance
Author(s): Jie Chen
Arjun K Gupta
Date:2012
Edition:Second Edition
Publisher:Boston : Birkhuser Boston
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Overall, the book gives a clear and systematic presentation of models and methods. It will be an excellent source for theoretical and applied statisticians who are interested in research on change-point analysis and itsapplications to many areas. Mat hematical Reviews (Review of the First Edition) Revised and expanded, Parametric Statistical Change Point Analysis, Second Edition is an in-depth study of the change point problem from a generalpoint of view, and a deeper look at change point analysis of the most commonly used statistical models. For some time, change point problems have appeared throughout the sciences in such disciplines as economics, medicine, psychology,signal processing, and geology more recently, they havealso been found extensively in applications related to biomedical imaging data, array Comparative Genomic Hybridization (aCGH) data, and gene expression data. These areas ofinterestnew and oldhave motivated substantial research on change point problems and led to a significant body of literature in the field. The present monograph stands as a valuable contribution to this literature. Key featuresand topics: * Clear and systematic exposition with a great deal of introductory material included * Different models in each chapter, incl uding gamma and exponential models, rarely examined thus far in the literature *Extensive examples to emphasize key concepts and different methodologies used, namely the likelihood ratio criterion as well as the Bayesian and information criterion approach es * An up-to-date comprehensive bibliography and twoindices. New to the Second Edition: * New examples of change point analysis in modern molecular biology and other fields such as finance and air traffic control * Two new sections of applications of the underlying change pointmodels in analyzing the array Comparative Genomic Hybridization (aCGH) data for DNA copy number changes * A new chapter on change points in the
Note:Springer eBooks
Contents:Preface
Preliminaries
Introduction
Univariate Normal Model
Multivariate Normal Model
Regression Model
Gamma Model
Exponential Model
Change Point Model for the Hazard Function
Discrete Models
Other Models
Bibliography
Author Index
Subject Index
ISBN:9780817648015
Series:e-books
Series:SpringerLink (Online service)
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Mathematics , Distribution (Probability theory) , Mathematical statistics , Economics Statistics
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Call number:SPRINGER-2011-9783790827361:ONLINE Show nearby items on shelf
Title:Recent Advances in Functional Data Analysis and Related Topics [electronic resource]
Author(s): Frdric Ferraty
Date:2011
Publisher:Heidelberg : Physica-Verlag HD
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:New technologies allow us to handle increasingly large datasets, while monitoring devices are becoming ever more sophisticated. This high-tech progress produces statistical units sampled over finer and finer grids. As themeasurement points become clo ser, the data can be considered as observations varying over a continuum. This intrinsic continuous data (called functional data) can be found in various fields of science, including biomechanics,chemometrics, econometrics, environmetrics, geophysics, med icine, etc. The failure of standard multivariate statistics to analyze such functional data has led the statistical community to develop appropriate statistical methodologies,called Functional Data Analysis (FDA). Today, FDA is certainly one of the most m otivating and popular statistical topics due to its impact on crucial societal issues (health, environment, etc). This is why the FDA statistical communityis rapidly growing, as are the statistical developments . Therefore, it is necessary to organize reg ular meetings in order to provide a state-of-art review of the recent advances in this fascinating area. This book collects selectedand extended papers presented at the second International Workshop of Functional and Operatorial Statistics (Santander, Spa in, 16-18 June, 2011), in which many outstanding experts on FDA will present the most relevant advances inthis pioneering statistical area. Undoubtedly, these proceedings will be an essential resource for academic researchers, master students, engineers, and practitioners not only in statistics but also in numerous related fields ofapplication.
Note:Springer eBooks
Contents:Penalized Spline Approaches for Functional Principal Component Logit
Functional Prediction for the Residual Demand in Electricity Spot
Variable Selection in Semi
Functional RegressionModels
Power Analysis for Functional Change Point Detection
Robust Nonparametric Estimation for Functional Spatial Regression
Sequential Stability Procedures for Functional Data Setups
On the Effect of Noisy Observations of the Regressor in a Functional Linear Model
Testing the Equality of Covariance Operators
Modeling and Forecasting Monotone Curves by FDA
Wavelet
Based Minimum Contras
ISBN:9783790827361
Series:e-books
Series:SpringerLink (Online service)
Series:Contributions to Statistics, 1431-1968
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Gene expression , Meteorology , Computer vision , Distribution (Probability theory)
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Call number:SPRINGER-2011-9783642195921:ONLINE Show nearby items on shelf
Title:Random Walks and Diffusions on Graphs and Databases [electronic resource] : An Introduction
Author(s): Philippe Blanchard
Dimitri Volchenkov
Date:2011
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Most networks and databases that humans have to deal with contain large, albeit finite number of units. Their structure, for maintaining functional consistency of the components, is essentially not random and calls for a precisequantitative descripti on of relations between nodes (or data units) and all network components. This book is an introduction, for both graduate students and newcomers to the field, to the theory of graphs and random walks on suchgraphs. The methods based on random walks and di ffusions for exploring the structure of finite connected graphs and databases are reviewed (Markov chain analysis). This provides the necessary basis for consistently discussing a numberof applications such diverse as electric resistance networks, estimat ion of land prices, urban planning, linguistic databases, music, and gene expression regulatory networks
Note:Springer eBooks
Contents:Introduction to Permutations, Markov Chains, and Partitions
Worth Another Binary Relation: Graphs
Permutations Sieved Through Adjacency: Garph Autormorphisms
Exploring Undirected Graphs by Random Walks
Embedding of Graphs in Probabilistic Euclidean Space
Random Walks and Electric Resistance Networks
Random Walks and Diffusions on Directed Graphs and Interacting Networks
Structural Analysis of Networks and Databases
When Feedbacks Matter: Epidemics, Synchronization, and Self
Regulation in Complex Networks
Critical Phenomena on Large Graphs With Regular Subgraphs
Gl
ISBN:9783642195921
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Synergetics, 0172-7389 : v10
Series:Physics and Astronomy (Springer-11651)
Keywords: Data structures (Computer science) , Cell aggregation Mathematics , Engineering
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Call number:SPRINGER-2009-9783540686514:ONLINE Show nearby items on shelf
Title:Medical Applications of Finite Mixture Models [electronic resource]
Author(s): Peter Schlattmann
Date:2009
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The book shows how to model heterogeneity in medical research with covariate adjusted finite mixture models. The areas of application include epidemiology, gene expression data, disease mapping, meta-analysis, neurophysiology andpharmacology. After a n informal introduction the book provides and summarizes the mathematical background necessary to understand the algorithms. The emphasis of the book is on a variety of medical applications such as gene expressiondata, meta-analysis and population pharmac okinetics. These applications are discussed in detail using real data from the medical literature. The book offers an R package which enables the reader to use the methods for his/her needs
Note:Springer eBooks
Contents:Introduction
Heterogeneity in Medicine
Modeling Count Data
Theory and Algorithms
Disease Mapping and Cluster Investigations
Modeling Heterogeneity in Psychophysiology
Investigating and Analyzing Heterogeneity in Meta
Analysis
Analysis of Gene Expression Data
ISBN:9783540686514
Series:e-books
Series:SpringerLink (Online service)
Series:Statistics for Biology and Health, 1431-8776
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Epidemiology , Statistical methods , Mathematical statistics
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Call number:SPRINGER-2008-9780387775166:ONLINE Show nearby items on shelf
Title:Strategies of Life Detection [electronic resource]
Author(s): Oliver Botta
Jeffrey L Bada
Javier Gomez-Elvira
Emmanuelle Javaux
Franck Selsis
Roger Summons
Date:2008
Publisher:Boston, MA : Springer US
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The search for life outside the Earth has been one of mankind's most challenging quests. We have reached a level of technology that allows for initial steps toward thorough scientific investigation. The aim of this workshop was totake an interdiscipl inary look at the signatures that would be indicative of past or present life on another planet and compare them to biosignatures on Earth. The purpose of the workshop was also to discuss state-of-the-art in-situinstruments that are envisioned to search f or these signatures in the exploration of the solar system, as well as the discussion of concepts descriptive of the search for habitable planets around other stars. This book is intended toprovide a reference to scientists and instrument developers worki ng in the field of in-situ and remote life detection. It can also be used as an interdisciplinary introduction for students and post-doctoral researchers entering thisnew and exciting field
Note:Springer eBooks
Contents:Foreword
Towards a Definition of Life: The Impossible Quest?
Infrared Spectroscopy of Solar
System Planets
Extraterrestrial Organic Matter and the Detection of Life
Astrobiology and Habitability of Titan
An Approach to Searching for Life on Mars, Europa, and Enceladus
Accretion, Trapping and Binding of Sediment in Archean StromatolitesMorphological Expression of the Antiquity of Life
Biogenerated Rock Structures
Morphological Biosignatures in Early Terrestrial andExtraterrestrial Materials
Gene Transfer and the Reconstruction of Lifes Early History from Genom
ISBN:9780387775166
Series:e-books
Series:SpringerLink (Online service)
Series:Space Sciences Series of ISSI, 1385-7525 : v25
Series:Physics and Astronomy (Springer-11651)
Keywords: Planetology , Biochemistry , Astronomy , Astrobiology
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Call number:SPRINGER-2008-9780387772400:ONLINE Show nearby items on shelf
Title:Bioconductor Case Studies [electronic resource]
Author(s): Florian Hahne
Wolfgang Huber
Robert Gentleman
Seth Falcon
Date:2008
Edition:1
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. Inthis volume, the auth ors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include * import and preprocessing of data from various sources * statisticalmodeling of differential gene expression * biolog ical metadata * application of graphs and graph rendering * machine learning for clustering and classification problems * gene set enrichment analysis Each chapter of this book describesan analysis of real data using hands-on example driven approaches. Sh ort exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executedon a local computer, and readers are able to reproduce every computation, figure, and table . The authors of this book have longtime experience in teaching introductory and advanced courses to the application of Bioconductor software.Florian Hahne is a Postdoc at the Fred Hutchinson Cancer Research Center in Seattle, developing novel methodologi es for the analysis of high-throughput cell-biological data. Wolfgang Huber is a research group leader in the EuropeanMolecular Biology Laboratory at the European Bioinformatics Institute in Cambridge. He has wide-ranging experience in the development of methods for the analysis of functional genomics experiments. Robert Gentleman is Head of theProgram in Computational Biology at the Fred Hutchinson Cancer Research Center in Seattle, and he is one of the two authors of the original R system. Seth Falcon i s a member of the R core team and former project manager and developerfor the Bioconductor project
Note:Springer eBooks
Contents:The ALL Dataset
R and Bioconductor Introduction
Processing Affymetrix Expression Data
Two Color Arrays
Fold Changes, Log Ratios, Background Correction, Shrinkage Estimation, and Variance Stabilization
Easy Differential Expression
Differential Expression
Annotation and Metadata
Supervised Machine Learning
Unsupervised Machine Learning
Using Graphs for Interactome Data
Graph Layout
Gene Set Enrichment Analysis
Hypergeometric Testing Used for Gene Set Enrichment Analysis
Solutions to Exercises
ISBN:9780387772400
Series:e-books
Series:SpringerLink (Online service)
Series:Use R!
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Bioinformatics , Biology Mathematics
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Call number:SPRINGER-2005-9780387266480:ONLINE Show nearby items on shelf
Title:Statistical Methods in Bioinformatics [electronic resource] : An Introduction
Author(s): Warren J Ewens
Gregory Grant
Date:2005
Edition:Second Edition
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in thestatistical methods n ecessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the researchcommunity. This book provides an introduction to some of these new methods. The main biological topics treated include sequence analysis, BLAST, microarray analysis, gene finding, and the analysis of evolutionary processes. The mainstatistical techniques covered include hypothesis testing and estimatio n, Poisson processes, Markov models and Hidden Markov models, and multiple testing methods. The second edition features new chapters on microarray analysis and onstatistical inference, including a discussion of ANOVA, and discussions of the statistical th eory of motifs and methods based on the hypergeometric distribution. Much material has been clarified and reorganized. The book is written soas to appeal to biologists and computer scientists who wish to know more about the statistical methods of the fiel d, as well as to trained statisticians who wish to become involved with bioinformatics. The earlier chapters introducethe concepts of probability and statistics at an elementary level, but with an emphasis on material relevant to later chapters and often not covered in standard introductory texts. Later chapters should be immediately accessible to thetrained statistician. Sufficient mathematical background consists of introductory courses in calculus and linear algebra. The basic biological concepts that are used are explained, or can be understood from the context, and standardmathematical concepts are summarized in an Appendix. Problems are provided at the end of each chapter allowing the reader to de
Note:Springer eBooks
Contents:Probability Theory (i): One Random Variable
Probability Theory (ii): Many Random Variables
Statistics (i): An Introduction to Statistical Inference
Stochastic Processes (i): Poisson Processes and Markov Chains
The Analysis of One DNA Sequence
The Analysis of Multiple DNA or Protein Sequences
Stochastic Processes (ii): Random Walks
Statistics (ii): Classical Estimation Theory
Statistics (iii): Classical Hypothesis Testing Theory
BLAST
Stochastic Processes (iii): Markov Chains
Hidden Markov Models
Gene Expression, Microarrays, and Multiple Testing
Evolution
ISBN:9780387266480
Series:e-books
Series:SpringerLink (Online service)
Series:Statistics for Biology and Health, 1431-8776
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Bioinformatics , Biology Mathematics
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Call number:SPRINGER-2004-9783790826562:ONLINE Show nearby items on shelf
Title:COMPSTAT 2004 — Proceedings in Computational Statistics 16th Symposium Held in Prague, Czech Republic, 2004
Author(s):
Date:2004
Size:1 online resource (580 p.)
Note:10.1007/978-3-7908-2656-2
Contents:Invited papers -- The history of COMPSTAT and key-steps of statistical computing during the last 30 years -- Hybrid algorithms for construction of D-efficient designs -- Geometry of learning in in multilayer perceptrons -- Visual data
mining for quantized spatial data -- Graphs for representing statistics indexed by nucleotide or amino acid sequences -- Matrix visualization and information mining -- st-apps and EMILeA-stat: Interactive visualizations in descriptive
statistics -- The case sensitivity function approach to diagnostic and robust computation: A relaxation strategy -- On the bootstrap methodology for functional data -- A novel approach to parametrization and parameter estimation in
linear dynamic systems -- Statistical analysis of handwritten Arabic numerals in a Chinese population -- Methods and algorithms for robust filtering -- Using GO for statistical analyses -- Computational challenges in determining an
optimal design for an experiment -- Visualization of parametric carcinogenesis models -- Design aspects of a computer simulation study for assessing uncertainty in human lifetime toxicokinetic models -- Simultaneous inference in risk
assessment a Bayesian perspective -- Interactive biplots for visual modelling -- R: The next generation -- Robust multidimensional scaling -- Improved jackknife variance estimates of bilinear model parameters -- Line mosaic plot:
Algorithm and implementation -- Graphical displays of Internet traffic data -- Clustering all three modes of three-mode data: Computational possibilities and problems -- Functional data analysis and mixed effect models -- Using weights
with a text proximity matrix -- On canonical analysis of vector time series -- Learning statistics by doing or by describing: The role of software -- Embedding methods and robust statistics for dimension reduction -- A general
partition cluster algorithm -- Iterative denoising for cross-corpus discovery -- From data to differential equations -- Simple simulations for robust tests of multiple outliers in regression -- The St@tNet project for teaching
statistics -- An automatic thresholding approach to gene expression analysis -- Kernel methods for manifold estimation -- Outlier detection and clustering by partial mixture modeling -- InterDatabase and DandD -- Exploratory visual
analysis of graphs in GGobi -- PLS regression and PLS path modeling for multiple table analysis -- 1001 graphics -- Fitting Bradley Terry Models using a multiplicative algorithm -- Modelling multiple time series: Achieving the aims --
Total least squares and errors-in-variables modeling: Bridging the gap between statistics, computational mathematics and engineering -- Author Index -- COMPSTAT 2004 Section Index
ISBN:9783790826562
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Mathematics , Mathematical statistics , Database management , Information storage and retrieval , Computer software , Probabilities , Statistics , Mathematics , Probability Theory and Stochastic Processes , Mathematical Software , Database Management , Statistics and Computing/Statistics Programs , Information Storage and Retrieval , Probability and Statistics in Computer Science
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Call number:SPRINGER-2004-9783642187568:ONLINE Show nearby items on shelf
Title:Multiscale Modelling and Simulation
Author(s):
Date:2004
Size:1 online resource (141 p.)
Note:10.1007/978-3-642-18756-8
Contents:I Mathematical Methods -- Some Recent Progress in Multiscale Modeling -- Homogenization Method for Transport of DNA Particles in Heterogeneous Arrays -- Metastability, conformation dynamics, and transition pathways in complex systems
-- Nonlinear Dynamics Analysis through Molecular Dynamics Simulations -- Exploration of coarse free energy surfaces templated on continuum numerical methods -- Damping factors for the gap-tooth scheme -- II Materials Science --
Multiscale Aspects of Polymer Simulations -- Polymers near a Surface: An ab initio Density Functional based Multiscale Modeling Approach -- Dual Resolution Molecular Simulation of Bisphenol-A Polycarbonate Adsorption onto Nickel (111):
Chain Length Effects -- Stress and energy flow field near a rapidly propagating mode I crack -- A Peierls Criterion for Deformation Twinning at a Mode II Crack -- III Physics/Chemistry/Fluid Dynamics/Biology -- Simulation of Transport
in Partially Miscible Binary Fluids: Combination of Semigrandcanonical Monte Carlo and Molecular Dynamics Methods -- Computer simulations of SiO2 and GeO2 -- Large Scale Density Functional Calculations -- Dispersion corrected density
functionals applied to the water naphthalene cluster -- Flow of Aqueous Solutions in Carbon Nanotubes -- Continuum-particle hybrid methods for dense fluids -- Dissipative Particle Dynamics for Modeling Complex Fluidics -- Population
balance modeling of synthesis of nanoparticles in aerosol flame reactors -- Modelling gene expression using stochastic simulation -- Color Plates
ISBN:9783642187568
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Computational Science and Engineering: 39
Keywords: Mathematics , Chemometrics , Computer mathematics , Mathematical models , Applied mathematics , Engineering mathematics , Mathematics , Mathematical Modeling and Industrial Mathematics , Computational Mathematics and Numerical Analysis , Appl.Mathematics/Computational Methods of Engineering , Math. Applications in Chemistry
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Call number:SPRINGER-2003-9783662050927:ONLINE Show nearby items on shelf
Title:Biochips Technology and Applications
Author(s):
Date:2003
Size:1 online resource (134 p.)
Note:10.1007/978-3-662-05092-7
Contents:Oligonucleotide Array Technologies for Gene Expression Profiling -- Medical Therapy: The Next Frontier of Biochip and Biomedical Nanotechnology -- Photobonding of Biomolecules for Biochip Manufacturing -- Opportunities and Obstacles
to the Routine Implementation of Microchips -- DNA Microarray Analysis of Gene Expression Profiles in Hepatocellular Carcinoma -- DNA Hybridization Detection by Electrochemical Impedance Spectroscopy and Photoelectrochemistry -- Data
Mining: An Integrated Approach for Drug Discovery -- Protein Array Detection with Nanoparticle Fluorescent Probes by Laser Confocal Scanning Fluorescence Detection -- Trends in Microfluidic Devices for Analytical Chemistry
ISBN:9783662050927
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Human genetics , Proteomics , Biophysics , Biological physics , Physical measurements , Measurement , Biomedical engineering , Nanotechnology , Physics , Biophysics and Biological Physics , Human Genetics , Biomedical Engineering , Proteomics , Nanotechnology , Measurement Science and Instrumentation
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Call number:SPRINGER-2003-9780387216799:ONLINE Show nearby items on shelf
Title:The Analysis of Gene Expression Data Methods and Software
Author(s):
Date:2003
Size:1 online resource (46 p.)
Note:10.1007/b97411
Contents:The Analysis of Gene Expression Data: An Overview of Methods and Software -- Visualization and Annotation of Genomic Experiments -- Bioconductor R Packages for Exploratory Analysis and Normalization of cDNA Microarray Data -- An R
Package for Analyses of Affymetrix Oligonucleotide Arrays -- DNA-Chip Analyzer (dChip) -- Expression Profiler -- An S-PLUS Library for the Analysis and Visualization of Differential Expression -- Dragon and Dragon View: Methods for the
Annotation, Analysis, and Visualization of Large-Scale Gene Expression Data -- Snomad: Biologist-Friendly Web Tools for the Standardization and NOrmalization of Microarray Data -- Microarray Analysis Using the MicroArray Explorer --
Parametric Empirical Bayes Methods for Microarrays -- SAM Thresholding and False Discovery Rates for Detecting Differential Gene Expression in DNA Microarrays -- Adaptive Gene Picking with Microarray Data: Detecting Important Low
Abundance Signals -- MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments -- GeneClust -- POE: Statistical Methods for Qualitative Analysis of Gene Expression -- Bayesian Decomposition -- Bayesian
Clustering of Gene Expression Dynamics -- Relevance Networks: A First Step Toward Finding Genetic Regulatory Networks Within Microarray Data
ISBN:9780387216799
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Statistics , Human genetics , Mathematical statistics , Biochemistry , Bioinformatics , Probabilities , Statistics , Statistics for Life Sciences, Medicine, Health Sciences , Probability Theory and Stochastic Processes , Biochemistry, general , Human Genetics , Bioinformatics , Probability and Statistics in Computer Science
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Call number:SPRINGER-2003-9780387215792:ONLINE Show nearby items on shelf
Title:Nonlinear Estimation and Classification
Author(s):
Date:2003
Size:1 online resource (477 p.)
Note:10.1007/978-0-387-21579-2
Contents:I Longer Papers -- 1 Wavelet Statistical Models and Besov Spaces -- 2 Coarse-to-Fine Classification and Scene Labeling -- 3 Environmental Monitoring Using a Time Series of Satellite Images and Other Spatial Data Sets -- 4 Traffic Flow
on a Freeway Network -- 5 Internet Traffic Tends Toward Poisson and Independent as the Load Increases -- 6 Regression and Classification with Regularization -- 7 Optimal Properties and Adaptive Tuning of Standard and Nonstandard
Support Vector Machines -- 8 The Boosting Approach to Machine Learning: An Overview -- 9 Improved Class Probability Estimates from Decision Tree Models -- 10 Gauss Mixture Quantization: Clustering Gauss Mixtures -- 11 Extended Linear
Modeling with Splines -- II Shorter Papers -- 12 Adaptive Sparse Regression -- 13 Multiscale Statistical Models -- 14 Wavelet Thresholding on Non-Equispaced Data -- 15 Multi-Resolution Properties of Semi-Parametric Volatility Models --
16 Confidence Intervals for Logspline Density Estimation -- 17 Mixed-Effects Multivariate Adaptive Splines Models -- 18 Statistical Inference for Simultaneous Clustering of Gene Expression Data -- 19 Statistical Inference for
Clustering Microarrays -- 20 Logic Regression — Methods and Software -- 21 Adaptive Kernels for Support Vector Classification -- 22 Generalization Error Bounds for Aggregate Classifiers -- 23 Risk Bounds for CART Regression Trees -- 24
On Adaptive Estimation by Neural Net Type Estimators -- 25 Nonlinear Function Learning and Classification Using RBF Networks with Optimal Kernels -- 26 Instability in Nonlinear Estimation and Classification: Examples of a General
Pattern -- 27 Model Complexity and Model Priors -- 28 A Strategy for Compression and Analysis of Very Large Remote Sensing Data Sets -- 29 Targeted Clustering of Nonlinearly Transformed Gaussians -- 30 Unsupervised Learning of Curved
Manifolds -- 31 ANOVA DDP Models: A Review
ISBN:9780387215792
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Statistics: 171
Keywords: Statistics , Statistics , Statistical Theory and Methods
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Call number:SPRINGER-2002-9789401003247:ONLINE Show nearby items on shelf
Title:Advances in Computational Intelligence and Learning Methods and Applications
Author(s):
Date:2002
Size:1 online resource (515 p.)
Note:10.1007/978-94-010-0324-7
Contents:Accuracy and Transparency of Fuzzy Systems -- Should Tendency Assessment Precede Rule Extraction by Clustering? (No!) -- A Review of Wavelet Networks, Wavenets, Fuzzy Wavenets and their Applications -- Investigating Neural Network
Efficiency and Structure by Weight Investigation -- An Evaluation of Confidence Bound Estimation Methods for Neural Networks -- Compensation of Periodic Disturbances in Continuous Processing Plants by Means of a Neural Controller --
Predictive Control with Restricted Genetic Optimisation -- Adaptive Parameterization of Evolutionary Algorithms and Chaotic Populations -- Neuro-Fuzzy Systems for Rule-Based Modelling of Dynamic Processes -- Hybrid Intelligent
Architectures using a Neurofuzzy Approach -- Unifying Learning with Evolution Through Baldwinian Evolution and Lamarckism -- Using An Evolutionary Strategy to Select Input Features for a Neural Network Classifier -- Advances in Machine
Learning -- Symbolic and Neural Learning of Named-Entity Recognition and Classification Systems in Two Languages -- Fuzzy Model-Based Reinforcement Learning -- A Cellular Space for Feature Extraction and Classification -- A Fuzzy
Approach to Taming the Bullwhip Effect -- Forecast of Short Term Trends in Stock Exchange using Fuzzy Rules and Neural Networks on Multiresolution Processed Signals -- Customer Relationship Management: A Combined Approach by Customer
Segmentation and Database Marketing -- A new Vendor Evaluation Product for SAP RJ3® Systems -- About Robustness of Fuzzy Logic PD and PID Controller under Changes of Reasoning Methods -- Control of MIMO Dead Time Processes Using Fuzzy
Relational Models -- Fuzzy Sliding Mode Controllers Synthesis through Genetic Optimization -- Fuzzy RED: Congestion Control for TCP/IP Diff-Serv -- The Use of Reinforcement Learning Algorithms in Traffic Control of High Speed Networks
-- Fuzzy Reasoning in WCDMA Radio Resource Functions -- Odour Classification based on Computational Intelligence Techniques -- Fuzzy Rule Based System for Diagnosis of Stone Construction Cracks of Buildings -- Automated Design of
Multi-Drilling Gear Machines -- Optimal Design of Alloy Steels Using Genetic Algorithms -- Intelligent Systems in Biomedicine -- Diagnosis Of Aphasia Using Neural And Fuzzy Techniques -- Gene Expression Data Mining for Functional
Genomics using Fuzzy Technology -- Symbolic, Neural and Neuro-fuizy Approaches to Pattern Recognition in Cardiotocograms -- Perspectives ofComputational Intelligence
ISBN:9789401003247
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:International Series in Intelligent Technologies: 18
Keywords: Mathematics , Operations research , Decision making , Artificial intelligence , Mathematical logic , Mathematics , Mathematical Logic and Foundations , Artificial Intelligence (incl. Robotics) , Operation Research/Decision Theory
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Call number:SPRINGER-2002-9783642561818:ONLINE Show nearby items on shelf
Title:Classification, Clustering, and Data Analysis Recent Advances and Applications
Author(s):
Date:2002
Size:1 online resource (508 p.)
Note:10.1007/978-3-642-56181-8
Contents:I. Clustering and Discrimination -- Clustering -- Some Thoughts about Classification -- Partial Defuzzification of Fuzzy Clusters -- A New Clustering Approach, Based on the Estimation of the Probability Density Function, for Gene
Expression Data -- Two-mode Partitioning: Review of Methods and Application of Tabu Search -- Dynamical Clustering of Interval Data Optimization of an Adequacy Criterion Based on Hausdorff Distance -- Removing Separation Conditions in
a 1 against 3-Components Gaussian Mixture Problem -- Obtaining Partitions of a Set of Hard or Fuzzy Partitions -- Clustering for Prototype Selection using Singular Value Decomposition -- Clustering in High-dimensional Data Spaces --
Quantization of Models: Local Approach and Asymptotically Optimal Partitions -- The Performance of an Autonomous Clustering Technique -- Cluster Analysis with Restricted Random Walks -- Missing Data in Hierarchical Classification of
Variables — a Simulation Study -- Cluster Validation -- Representation and Evaluation of Partitions -- Assessing the Number of Clusters of the Latent Class Model. -- Validation of Very Large Data Sets Clustering by Means of a
Nonparametric Linear Criterion -- Discrimination -- Effect of Feature Selection on Bagging Classifiers Based on Kernel Density Estimators -- Biplot Methodology for Discriminant Analysis Based upon Robust Methods and Principal Curves --
Bagging Combined Classifiers -- Application of Bayesian Decision Theory to Constrained Classification Networks -- II. Multivariate Data Analysis and Statistics -- Multivariate Data Analysis -- Quotient Dissimilarities, Euclidean
Embeddability, and Huygens’ Weak Principle -- Conjoint Analysis and Stimulus Presentation — a Comparison of Alternative Methods -- Grade Correspondence-cluster Analysis Applied to Separate Components of Reversely Regular Mixtures --
Obtaining Reducts with a Genetic Algorithm -- A Projection Algorithm for Regression with Collinearity -- Confronting Data Analysis with Constructivist Philosophy -- Statistical Methods -- Maximum Likelihood Clustering with Outliers --
An Improved Method for Estimating the Modes of the Probability Density Function and the Number of Classes for PDF-based Clustering -- Maximization of Measure of Allowable Sample Sizes Region in Stratified Sampling -- On Estimation of
Population Averages on the Basis of Cluster Sample -- Symbolic Data Analysis -- Symbolic Regression Analysis -- Modelling Memory Requirement with Normal Symbolic Form -- Mixture Decomposition of Distributions by Copulas --
Determination of the Number of Clusters for Symbolic Objects Described by Interval Variables -- Symbolic Data Analysis Approach to Clustering Large Datasets -- Symbolic Class Descriptions -- Consensus Trees and Phylogenetics -- A
Comparison of Alternative Methods for Detecting Reticulation Events in Phylogenetic Analysis -- Hierarchical Clustering of Multiple Decision Trees -- Multiple Consensus Trees -- A Family of Average Consensus Methods for Weighted Trees
-- Comparison of Four methods for Inferring Additive Trees from Incomplete Dissimilarity Matrices -- Quartet Trees as a Tool to Reconstruct Large Trees from Sequences -- Regression Trees -- Regression Trees for Longitudinal Data with
Time-dependent Covariates -- Tree-based Models in Statistics: Three Decades of Research -- Computationally Efficient Linear Regression Trees -- Neural Networks and Genetic Algorithms -- A Clustering Based Procedure for Learning the
Hidden Unit Parameters in Elliptical Basis Function Networks -- Multi-layer Perceptron on Interval Data -- III. Applications -- Textual Analysis of Customer Statements for Quality Control and Help Desk Support -- AHP as Support for
Strategy Decision Making in Banking -- Bioinformatics and Classification: The Analysis of Genome Expression Data -- Glaucoma Diagnosis by Indirect Classifiers -- A Cluster Analysis of the Importance of Country and Sector on Company
Returns -- Problems of Classification in Investigative Psychology -- List of Reviewers
ISBN:9783642561818
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Computer science , Mathematical statistics , Database management , Applied mathematics , Engineering mathematics , Probabilities , Statistics , Computer Science , Database Management , Probability Theory and Stochastic Processes , Applications of Mathematics , Statistical Theory and Methods , Probability and Statistics in Computer Science , Statistics for Business/Economics/Mathematical Finance/Insurance
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Call number:SPRINGER-2001-9781447107156:ONLINE Show nearby items on shelf
Title:Advances in Self-Organising Maps
Author(s): Nigel Allinson
Date:2001
Size:1 online resource (289 p.)
Note:10.1007/978-1-4471-0715-6
Contents:Towards an information-theoretic approach to kernel-based topographic map formation -- A statistical tool to assess the reliability of self-organising maps -- A SOM association network -- A supervised self-organising map for
structured data -- Human gait analysis using SOM -- Exploring financial crises data with self-organising maps (SOM) -- Analysing health inequalities using SOM -- Integrating contextual information into text document clustering with
self-organising maps -- Self-organising Internet semantic network -- Recursive learning rules for SOMs -- Induced Voronoï kernels for principal manifolds approximation -- Visualisation induced SOM (ViSOM) -- An approach to automated
interpretation of SOM -- VQ-based clustering algorithm of piecewise-dependant-data -- Adaptive subspace encoders using stochastic vector quantisers -- SHAPESOM -- A new interpolation algorithm employing a self organising map --
SOM-based exploratory analysis of gene expression data -- Exploring power transformer database using self-organising maps (SOM) and minimal spanning tree (MST) -- Recent advances with the growing hierarchical self-organising Map --
Self-organising maps of web link information -- A design method of DNA chips using self-organising maps -- Multi-dimensional self-organising maps on massively parallel hardware -- A new method of Hough transform by using SOM with input
vector transformation -- Estimating relevant input dimensions for self-organising algorithms -- An overview on unsupervised learning from data mining perspective -- Recursive self-organising maps -- An investigation into catastrophic
interference on a SOM network -- A topography-preserving latent variable model with learning metrics -- Vector quantisation with ?-observable neighbors -- Dynamic vector quantisation of speech -- Optimisation of electronic parts
mounting machines using SOM-TSP method with 5 dimensional data -- Self-organising maps for condition assessment of paper insulated cables -- An essay in classifying self-organising maps for temporal sequence processing -- Evaluating
SOM-based models in text classification tasks for the Greek language -- Nonlinear blind source separation using SOMs and applications to image denoising -- Signal-based feature extraction and SOM based dimension reduction in a
vibration monitoring microsystem -- Author index
ISBN:9781447107156
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Mathematics , Image processing , Pattern recognition , Applied mathematics , Engineering mathematics , Electrical engineering , Mathematics , Applications of Mathematics , Pattern Recognition , Electrical Engineering , Image Processing and Computer Vision
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Call number:SPRINGER-2000-9789401009485:ONLINE Show nearby items on shelf
Title:Computational Aerosciences in the 21st Century Proceedings of the ICASE/LaRC/NSF/ARO Workshop, conducted by the Institute for Computer Applications in Science and Engineering, NASA Langley Research Center, The National Science Foundation and the Army Research Office, April 22–24, 1998
Author(s):
Date:2000
Size:1 online resource (292 p.)
Note:10.1007/978-94-010-0948-5
Contents:Isaac Inside: The Cultural Filters on Truly New Computing -- 3-D Geometric Model Acquisition System for a Tele-collaboration Testbed -- The Emerging Grid -- Distributed Systems on the Pragmatic Object Web Computing with Java and CORBA
-- From Gene Expression to Large Scale Evolutionary Optimization -- Trends in Algorithms for Nonuniform Applications on Hierarchical Distributed Architectures -- Quantum Computation -- Generation of Unstructured Grids Suitable for RANS
Calculations -- The Future of Lattice-gas and Lattice Boltzmann Methods -- Unstructured Grid Generation for Aerospace Applications -- Geometry Modeling and Grid Generation for Design and Optimization -- NASA’s Information Power Grid
Project -- Enabling Greater than 100 Teraflops through a Synthesis of Alternative Technologies -- From Molecular Dynamics t o Navier-Stokes and Beyond -- List of Attendees
ISBN:9789401009485
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:ICASE LaRC Interdisciplinary Series in Science and Engineering: 8
Keywords: Mathematics , Microprocessors , Computers , Numerical analysis , Mathematical models , Number theory , Aerospace engineering , Astronautics , Mathematics , Number Theory , Aerospace Technology and Astronautics , Numeric Computing , Theory of Computation , Processor Architectures , Mathematical Modeling and Industrial Mathematics
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Call number:SPRINGER-1999-9789401146159:ONLINE Show nearby items on shelf
Title:NMR in Supramolecular Chemistry
Author(s):
Date:1999
Size:1 online resource (337 p.)
Note:10.1007/978-94-011-4615-9
Contents:Probing Self-Assembly by NMR -- Study of Conformational Behavior of CMP(O)-Cavitands by NMR Spectroscopy and X-Ray Analysis in Relation to the Extraction Properties -- NMR Studies of Molecular Recognition by Metalloporphyrins --
Reversible Dimerization of Tetraureas Derived from Calix[4]arenes -- Self-Assembling Peptide Nanotubes -- Symmetry: Friend or Foe? -- Quenching Spin Diffusion in Transferred Overhauser Studies and Detection of Octupolar Order in
Gaseous Xenon-131 -- Applications of NMR Spectroscopy to the Study of the Bound Conformation of O- and C-Glycosides to Lectins and Enzymes -- Application of NMR to Conformational Studies of an HIV Peptide Bound to a Neutralizing
Antibody -- Paramagnetic NMR Effects of Lanthanide Ions as Structural Reporters of Supramolecular Complexes -- Characterization of Reaction Complex Structures of ATP-Utilizing Enzymes by High Resolution NMR -- Spin Relaxation Methods
for Characterizing Picosecond-Nanosecond and Microsecond-Millisecond Motions in Proteins -- Structural Diversity of the Osmoregulated Periplasmic Glucans of Gram-Negative Bacteria by a Combined Genetics and Nuclear Magnetic Resonance
Approach -- NMR Studies of the 269 Residue Serine Protease PB92 from Bacillus Alcalophilus -- Intermolecular Interactions of Proteins Involved in the Control of Gene Expression -- NMR-Based Modeling of Protein-Protein Complexes and
Interaction of Peptides and Proteins with Anisotropic Solvents -- Protein Surface Recognition -- NMR Studies of Protein-Ligand and Protein-Protein Interactions Involving Proteins of Therapeutic Interest -- NMR Diffusion Measurements in
Chemical and Biological Supramolecular Systems -- Determination of Calixarene Conformations by Means of NMR Techniques -- Structure, Molecular Dynamics, and Host-Guest Interactions of a Water-Soluble Calix[4]arene -- Cation
Complexation and Stereochemistry of Macrocycles Studied by 13C NMR Relaxation-Time Measurements -- A Comparative Study on Liquid State CSA Methods -- Hydrogen Bonding and Cooperativity Effects on the Assembly of Carbohydrates --
Influence of Substituents on the Edge-to-Face Aromatic Interaction: Halogens
ISBN:9789401146159
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO ASI Series, Series C: Mathematical and Physical Sciences: 526
Keywords: Chemistry , Analytical chemistry , Inorganic chemistry , Organic chemistry , Physical chemistry , Chemistry , Analytical Chemistry , Organic Chemistry , Inorganic Chemistry , Physical Chemistry
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Call number:SPRINGER-1997-9789401139731:ONLINE Show nearby items on shelf
Title:Chemosensors of Ion and Molecule Recognition
Author(s):
Date:1997
Size:1 online resource (245 p.)
Note:10.1007/978-94-011-3973-1
Contents:Modification of cyclodextrins to control their guest-host chemistry and their application as chemosensors -- New fluorescent readouts for protein interactions, gene expression, and membrane potential -- Chemical sensors based on field
effect transistors selective recognition of cations and anions -- Aqueous sugar sensing by boronic-acid-based artificial receptors -- Solid state supramolecular optical sensors -- Fluorescent chemosensors which take profit from the
metalligand interaction -- Recognition, transduction and immobilisation- A holistic approach to sensor development -- Signal transduction in chemosensors of modified cyclodextrins -- Hydrogen bonding chemosensors for metabolites and
nucleotides -- New approaches to sensory materials: Molecular recognition in conjugated polymers. New transduction methodology -- Higher generation luminescent PET (photoinduced electron transfer) sensors -- Chemosensing of monocyclic
and bicyclic aromatic hydrocarbons by supramolecular active sites -- Squaraine-based long wavelength fluorescent chemosensors for ions -- A fluorescent chemosensor with selectivity for Hg(II). Chelatoselectivity via ligand
immobilization -- Cation-responsive fluorescent sensors -- Fluorescent, siderophore-based hydroxamate chelators for the detection of transition-metalions -- Author index
ISBN:9789401139731
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO ASI Series, Series C: Mathematical and Physical Sciences: 492
Keywords: Chemistry , Analytical chemistry , Organic chemistry , Physical chemistry , Chemistry , Analytical Chemistry , Physical Chemistry , Organic Chemistry , Chemistry/Food Science, general
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Call number:SPRINGER-1990-9789400919365:ONLINE Show nearby items on shelf
Title:Activation of Hormone and Growth Factor Receptors Molecular Mechanisms and Consequences
Author(s):
Date:1990
Size:1 online resource (320 p.)
Note:10.1007/978-94-009-1936-5
Contents:Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences: A record of the Meeting -- Signal Transduction and Control of Cell Proliferation and Differentiation -- Insulin Receptor and Insulin Action --
Signal Transduction by Growth Factor Receptors -- Cholera Toxin: Transport and Structural Basis of Action -- Analysis and Transfection of Human Acidic Fibroblast Growth Factor (aFGF) cDNA Clones and Structural Analysis of the Human
aFGF Gene reveals Features Shared within a Family of Homologous Proteins -- Growth Factor Synthesis by a Human Teratocarcinoma cell line: Implications for Autocrine Growth in the Human Embryo? -- The Role of Oncogene Activation -- The
Role of Ras P21 Product in Cell Transformation -- DNA Binding Properties of the Thyroid Hormone Receptor/c-erbA Protein and its Viral Homologue P75 gag-v-erbA -- The Role of Fos in Gene Regulation -- 6-Phosphofructo-2-Kinase links
Glycolysis to Mitogenic Agents and has Sequence Similarity with Proteins encoded by Oncogenic DNA Viruses -- Steroid Receptors and Transcriptional Control -- The Regulation of RNA Polymerase II Activity by Multisite Phosphorylation --
Transcription Factors of RNA Polymerase III from Mammalian Cells -- Steroid response elements: Composite Structure and Definition of a Minimal Element -- Gene Regulation by Steroid Hormones -- Regulation of Liver Gene Expression in
Dexamethasone Resistant Hepatoma Cells -- The Kinetics of Oestrogen-induced Gene Expression in the Immature Rat Uterus -- Structure and Function of Steroid Receptors -- Functional Domains of Steroid Hormone Receptors -- Genetic and
Biochemical Analysis of a Steroid Receptor -- Analysis of Subunit Interactions in Steroid Receptors using Chemical Cross-Linking -- Possible Functional Interaction between Steroid Hormone Receptors and Heat Shock Protein Mr 90.000 (hsp
90) -- Mechanism of Action of Estrogens: Phosphorylation of Estradiol Receptor on Tyrosine -- Glucocorticoid Receptor and Hormonal Extragenomic Effects -- Clinical Implications of Steroid Receptor Research -- Estrogen Receptors in
Mouse Mammary Tumors -- Structure of Glucocorticoid Receptor in Cancer Tissues
ISBN:9789400919365
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO ASI Series, Series C: Mathematical and Physical Sciences: 295
Keywords: Life sciences , Biochemistry , Zoology , Animal anatomy , Animal physiology , Life Sciences , Zoology , Animal Anatomy / Morphology / Histology , Animal Physiology , Biochemistry, general
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Call number:SPRINGER-1990-9781468458350:ONLINE Show nearby items on shelf
Title:Bioenergetics Molecular Biology, Biochemistry, and Pathology
Author(s):
Date:1990
Size:1 online resource (484 p.)
Note:10.1007/978-1-4684-5835-0
Contents:Opening Session -- Introductory Remarks -- Opening Lecture -- Special Session -- Memories of My Flavoprotein Research -- I. Biochemistry 1. Mitochondrial Electron Transfer -- An Overview of Ubiquinone Proteins -- Studies on the
Mechanism of Action of the Mitochondrial Energy-Linked Nicotinamide Nucleotide Transhydrogenase -- Structures of Beef Mitochondrial Complex I Subunits -- Inhibition of the Mitochondrial Complex I Activity by Fatty Acid Derivatives of
Vanillylamide -- New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-Ubiquinone Oxidoreductase in the Respiratory Chain II -- Effects of Redox State for Ubiquinone-10 on the Membrane Fluidity of
Cardiolipin-Containing Liposomes -- Features of Assembly and Mechanism of Yeast Mitochondrial Ubiquinol: Cytochrome c Oxidoreductase -- Structural Studies of Euglena Cytochrome c1 -- How Well is Cytochrome c Engineered? -- Subunit I is
the Catalytic Center of P. denitrificans Cytochrome c Oxidase -- The Separation between Cytochrome a and Cytochrome a3 in the Absolute Spectrum -- I. 2. Energy Coupling and Ion Transport -- Which Electron-Transferring Reactions in the
Respiratory Chain Contribute to the Energy Conservation? -- Cytochrome Oxidase and Peroxide Metabolism -- Do Hydrogen Ions Serve as Bioenergetic Messengers in Yeast? -- Molecular Organization and Regulation of the Protonmotive System
of Mammalian ATP Synthase -- Situation of Archaebacterial ATPase among Ion-Translocating ATPases -- Structure and Chemical Modification of Pig Gastric (H++K+)-ATPase -- Inhibition of the Uncoupler-Induced Mitochondrial ATP-Hydrolysis
by the Cooperative Work of the ATPase Inhibitor, 9K Protein and 15K Protein -- Reconstitution of H+ATPase into Planar Phospholipid Bilayers and its Kinetic Analysis -- A Mitochondrial Carrier Family for Solute Transport -- The Calcium
Pump of the Plasma Membrane: Structure/Function Relationships -- I.3. Other Related Topics -- The 9-kDa Polypeptide with Iron-Sulfur Centers A/B in Spinach Photosystem I with Special Reference to its Structure and Topographic
Consideration in Thylakoid Membrane -- A Photo-Signal Transducing Photoreceptor (Stentorin) in Stentor coeruleus: A Brief Review -- Theory and Applications of the Kinetics of Substrate Reaction during Irreversible Modification of
Enzyme Activity -- High Pressure Kinetic Studies on Certain Hemoproteins -- The Purification and Properties of Glycerol-3-Phosphate Dehydrogenase in the Mitochondrial Inner Membrane -- II. Molecular Biology -- Subunit 8 of Yeast
Mitochondrial ATP Synthase: Biochemical Genetics and Membrane Assembly -- Gene Structure of Human ATP Synthase Beta Subunit -- Molecule and Gene of Sulfolobus acidocaldarius ATPase -- Nuclear Genes Encoding Two Subunits of Human
Mitochondrial Cytochrome bc1 Complex, Cytochrome c1 and Ubiquinone-Binding Protein: Their Structural Organization of the 5?-Flanking Regions and Chromosomal Localization -- Studies on the Function of the Mitochondrial Hinge Protein:
Molecular Genetic Approach Using Yeast as a Model System -- Molecular Evolution and Biology of Human Mitochondrial DNA -- III. Mitochondrial Pathology -- Stable and Unstable Bioenergetics in Vivo -- Regulation of Activity and
Tissue-Specific Expression of Cytochrome c Oxidase Genes under Normal and Pathological Conditions -- Mitochondrial DNA Mutations as an Etiology of Human Degenerative Diseases -- Mitochondrial Myopathies: Morphological Approach to
Molecular Abnormalities -- S1 Nuclease Analysis and Direct Sequencing of Deleted Mitochondrial DNA in Myopathic Patients: Role of Directly Repeated Sequences in Deletion -- Thirty Years of Mitochondrial Pathophysiology: From Luft's
Disease to Oxygen Toxicity -- Participants -- Author Index
ISBN:9781468458350
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Biochemistry , Biophysics , Biological physics , Physics , Biophysics and Biological Physics , Biochemistry, general
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Call number:SPRINGER-1989-9781461314752:ONLINE Show nearby items on shelf
Title:Understanding Insulin Action Principles and Molecular Mechanisms
Author(s): J Espinal
Date:1989
Size:1 online resource (129 p.)
Note:10.1007/978-1-4613-1475-2
Contents:1 Introduction -- 1.1 A short account of the discovery of insulin -- 1.2 An overview of insulin action and diabetes -- 2 Insulin: Chemistry, Synthesis and Secretion -- 2.1 The insulin molecule -- 2.2 Insulin synthesis -- 2.3 Insulin
secretion -- 3 Pathophysiology of Insulin -- 3.1 Introduction -- 3.3 Diabetes -- 4 Molecular Mechanisms Involved in Insulin Action -- 4.1 Regulation of protein phosphorylation -- 4.2 Insulin regulation of protein traffic -- 4.3
Regulation of gene expression -- 5 The Insulin Receptor -- 5.1 Receptor structure -- 5.2 The insulin receptor tyrosine kinase -- 5.3 Insulin receptor internalization -- 6 Molecular Mechanisms of Insulin Signal Transduction -- 6.1 The
cAMP system -- 6.2 The inositoltrisphosphate-diacylglycerol system -- 6.3 The involvement of glycosylphosphatidylinositol (GPI) in insulin action -- 7 Summary and Perspectives -- 7.1 Summary -- 7.2 Perspectives
ISBN:9781461314752
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Life sciences , Biochemistry , Plant physiology , Life Sciences , Biochemistry, general , Plant Physiology
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Call number:SPRINGER-1986-9781461321293:ONLINE Show nearby items on shelf
Title:Biophysics and Cancer
Author(s): Claudio Nicolini
Date:1986
Size:1 online resource (480 p.)
Note:10.1007/978-1-4613-2129-3
Contents:1. Normal Cells and Cancer Cells: Macromolecular Structures and Cellular Functions -- 1.1. Background -- 1.2. Native Chromatin-DNA Structure -- 1.3. Nuclear Structure -- 1.4. What Is a Gene? -- 1.5. Ribosomes -- 1.6. Modification in
the Control of Cell Proliferation -- 1.7. Modifications in the Control of Cell Differentiation -- 1.8. Modifications in the Control of Cell Transformation -- 1.9. Modifications in the Control of Cellular Aging -- 1.10. Membranes --
1.11. Cytoskeleton -- 1.12. Control Mechanisms for Normal versus Abnormal Cell Growth -- 1.13. Molecular Mechanisms and Models for Gene Expression -- 1.14. Conclusions and Future Trends -- 2. Cancer Cause and Prevention -- 2.1.
Background -- 2.2. Possible Causes of Cancer -- 2.3. Cancer Prevention -- 3. Cancer Detection and Treatment -- 3.1. Background -- 3.2. Present Status of Human Cancer Detection and Treatment -- 3.3. Alternative Analytical Approaches --
3.4. New Observables -- 3.5. Theoretical Simulation at the Cellular Level: Optimized Drug Metabolism Parameters in Animals -- 3.6. Treatment Optimization in Animals -- 3.7. Drug Interaction and Molecular Perturbation in Animals -- 3.8.
Extrapolation to Human Cancer -- 4. Experimental Probes -- 4.1. Background -- 4.2. Preparative Tools -- 4.3. Probes for Lower-Order Structures -- 4.4. Probes for Higher-Order Structures in Situ -- 5. Theoretical Probes -- 5.1.
Background -- 5.2. Enzyme Kinetics -- 5.3. Signal Processing and Analysis -- 5.4. Statistical Mechanics and Thermodynamics of Cell Structures -- 5.5. Polyelectrolyte Theory of Interactions among Biopolymers -- 5.6. Physicochemical
Model for Dye-Nucleic Acid Interaction in Situ -- 5.7. Electromagnetic Theory of Polarized Light Scattering by Large Biopolymers -- 5.8. Random Walk Model of Biopolymers -- 5.9. Mean Field Theory of Gel Biopolymers -- Epilogue: A Final
Comment -- Problems -- References
ISBN:9781461321293
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Oncology , Animal physiology , Biophysics , Biological physics , Physics , Biophysics and Biological Physics , Oncology , Animal Physiology
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Call number:SPRINGER-1983-9783642688775:ONLINE Show nearby items on shelf
Title:Biophysics
Author(s):
Date:1983
Size:1 online resource (941 p.)
Note:10.1007/978-3-642-68877-5
Contents:1 The Structure of Cells (Prokaryotes, Eukaryotes) -- 1.1 Characteristics of Cells -- 1.2 Cell Organelles -- 1.3 Nuclear and Cell Division -- 1.4 Evolution of the Eucyte -- 1.5 Viruses and Bacteriophages -- 2 The Chemical Structure of
Biologically Important Macromolecules -- 2.1 Introduction -- 2.2 Nucleic Acids and Their Structure -- 2.3 Proteins and Their Structure -- 3 Structure Determination of Biomolecules by Physical Methods -- 3.1 Size and Shape -- 3.2
Internal Structure -- 3.3 Electron-spin Resonance Spectroscopy -- 3.4 Nuclear Magnetic Resonance Spectroscopy -- 4 Intra- and Intermolecular Interactions -- 4.1 Introduction -- 4.2 Primary Structure -- 4.3 Interactions Between
Structural Units -- 4.4 Charge-transfer Reaction in Biomolecules -- 4.5 Conformational Transitions in Biopolymers -- 4.6 Polar Interactions, Hydration, Proton Conduction and Conformation of Biological Systems — Infrared Results -- 4.7
Debye-Hückel Theory (Forces between Molecules in Solution) -- 4.8 Polyelectrolytes and Their Interaction -- 5 Mechanisms of Energy Transfer -- 5.1 Photophysics and Photochemistry. General Principles -- 5.2 Energy Transfer Mechanisms --
6 Radiation Biophysics. Ernst-Georg Niemann -- 6.1 Introduction -- 6.2 Radiation and Its Measurement -- 6.3 Description and Interpretation of Radiation Action -- 6.4 Molecular Effects of Radiation -- 6.5 Radiation Effects on
Biomolecules and Molecular Structures -- 6.6 Radiation Effects on Cells and Organisms -- 6.7 Radiation Hazards and Radiation Protection -- 7 Isotope Methods Applied in Biology -- 7.1 Introduction -- 7.2 Stable and Radioactive Isotopes
-- 7.3 Isotope Effects -- 7.4 Analytic Isotope Application -- 7.5 Some Examples for the Application of Isotopes -- 8 Energetic and Statistical Relations -- 8.1 General -- 8.2 Basic Concepts of Thermodynamics -- 8.3 Energy Flux, ATP,
Transfer Potentials and Coupled Reactions -- 8.4 Statistical Interpretation of Thermodynamic Quantities -- 8.5 Theory of Absolute Reaction Rates -- 8.6 Irreversible Thermodynamics — An Overview -- 8.7 Biological Energy Conservation --
9 Enzymes as Biological Catalysts -- 9.1 Introduction -- 9.2 How do Enzymes work? -- 9.3 How Are Enzymes Regulated? -- 9.4 Protein Structure (Globular Proteins) -- 9.5 Examples -- 9.6 Structural Organization of Proteins -- 10 The
Biological Function of Nucleic Acids -- 10.1 Introduction -- 10.2 DNA Replication -- 10.3 Gene Expression -- 10.4 Regulation of Gene Expression -- 11 Thermodynamics and Kinetics of Self-assembly -- 11.1 General Features -- 11.2 Linear
Association -- 11.3 Equilibrium -- 11.4 Kinetics -- 11.5 Size Distribution and Length Determination -- 11.6 Other Effects -- 12 Membranes -- 12.1 Biomembrane Models -- 12.2 Physical Foundations of the Molecular Organization and
Dynamics of Membranes -- 12.3 Membrane Potentials -- 12.4 Control of Differentiation and Growth by Endogenous Electric Currents -- 12.5 Transport of Matter Through Biological Membranes -- 12.6 Biophysics of Respiratory Gas Transport --
13 Photobiophysics -- 13.1 Photosynthesis -- 13.2 Photomorphogenesis -- 13.3 Bioluminescence -- 14 Biomechanics -- 14.1 The Molecular Physiology of Contractivity and Motility -- 14.2 The Biophysics of Locomotion on Land -- 14.3 The
Biophysics of Locomotion in Water -- 14.4 Th Biophysics of Locomotion in Air -- 14.5 Biostatics -- 14.6 Biomechanics of the Cardiovascular System -- 14.7 Water and Solute Movement in Plants -- 15 Neurobiophysics -- 15.1 Excitation, its
Conduction and Synaptic Transmission -- 15.2 Biophysics of Sensory Mechanisms -- 16 Cybernetics -- 16.1 Information Theory and Communication Theory -- 16.2 Introduction into Cybernetics of Orientation Behavior -- 16.3 System Theory of
Perception Processes -- 16.4 Systems Analytical Behavioral Research: as Illustrated with the Fly -- 16.5 Aspects on Biophysics of Biological Oscillations -- 17 Evolution -- 17.1 Self-organization of Matter and Early Evolution of Life
-- 17.2 From Biological Macromolecules to Protocells - The Principle of Early Evolution -- 17.3 Chemical Evolution and the Origin of Living Systems
ISBN:9783642688775
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Biophysics , Biological physics , Physics , Biophysics and Biological Physics , Applied and Technical Physics , Biomedicine general
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Call number:SPRINGER-1983-9781461337393:ONLINE Show nearby items on shelf
Title:Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk
Author(s):
Date:1983
Size:1 online resource (341 p.)
Note:10.1007/978-1-4613-3739-3
Contents:Session I. Introduction -- How Much Progress this Time? -- Session II. Detection of Specific Locus Mutations in Somatic Cells -- Human Mutagenicity Monitoring: Studies with 6-Thioguanine Resistant Lymphocytes -- Detection of Somatic
Mutants of Hemoglobin -- Counting of RBC Variants Using Rapid Flow Techniques -- Biochemical Approaches to Monitoring Human Populations for Germinal Mutation Rates: II. Enzyme Deficiency Variants as a Component of the Estimated Genetic
Risk -- Session III. Human Monitoring — Detection of Specific Locus Mutations in Germ Cells -- Biochemical Approaches to Monitoring Human Populations for Germinal Mutation Rates: I. Electrophoresis -- Session IV. Utilization of Model
Systems in Mice: Part I -- The Detection of ENU-Induced Mutants in Mice by Electrophoresis and The Problem of Evaluating the Mutation Rate Increase -- Relation of Mouse Specific Locus Tests to Other Mutagenicity Tests and to Risk
Estimation -- The Detection of Induced Recessive Lethal Mutations in Mice -- Session V. Utilization of Model Systems in Mice: Part II -- Using Inversions to Detect and Study Recessive Lethals and Detrimentals in Mice -- Cataracts —
Indicators for Dominant Mutations in Mice and Man -- Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice -- Detection of Enzyme Activity Variants in Mice -- Some Factors Affecting the
Mutagenic Response of Mouse Germ Cells to Chemicals -- Session VI. Detailed Analysis of Specific Locus Mutations -- Qualitative Analysis of Mouse Specific-Locus Mutations: Information on Genetic Organization, Gene Expression, and the
Chromosomal Nature of Induced Lesions -- Developmental Genetics of Specific Locus Mutations -- Dominant and Recessive Effects of Electrophoretically Detected Specific Locus Mutations -- Session VII. Future Directions -- Some Ideas on
Future Test Systems -- Problems in Extrapolation of Animal Data to Humans -- Specific Locus Mutations in the Monitoring of Human Populations for Genetic Damage -- Some Research Needs to Support Mutagenicity Risk Assessments from Whole
Mammal Studies -- Contributors
ISBN:9781461337393
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 28
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1981-9781461331803:ONLINE Show nearby items on shelf
Title:Cellular and Molecular Aspects of Implantation
Author(s):
Date:1981
Size:1 online resource (518 p.)
Note:10.1007/978-1-4613-3180-3
Contents:I: Perspectives -- 1 Viviparity -- 2 My Life with Mammalian Eggs -- II: Cell Biology of the Developing Egg -- 3 The Origin of Trophoblast and Its Role in Implantation -- 4 The Generation and Recognition of Positional Information in
the Preimplantation Mouse Embryo -- 5 Relationship between the Programs for Implantation and Trophoblast Differentiation -- 6 Cellular and Genetic Analysis of Mouse Blastocyst Development -- III: Macromolecular Synthesis in the
Developing Egg -- 7 Mobilization of Genetic Information in the Early Rabbit Trophoblast -- 8 Activity of RNA and DNA Polymerases in Delayed-Implanting Mouse Embryos -- 9 A Reexamination of Messenger RNA Populations in the
Preimplantation Mouse Embryo -- 10 Intrinsic and Extrinsic Patterns of Molecular Differentiation during Oogenesis, Embryogenesis, and Organogenesis in Mammals -- IV: Uterine Preparation for Implantation -- 11 Cell Proliferation and
Cell Death in the Endometrium -- 12 Shifts in Uterine Stromal Cell Populations during Pregnancy and Regression -- 13 Separated Cell Types as Analytical Tools in the Study of Decidualization and Implantation -- 14 Decidual Cell
Function: Role of Steroid Hormones and Their Receptors -- V: Gene Expression in the Uterus -- 15 Mechanisms of Induction of Uterine Protein Synthesis: Hormonal Regulation of Uteroglobin -- 16 Regulation of the Levels of mRNA for
Glucose-6-phosphate Dehydrogenase and Its Rate of Translation in the Uterus by Estradiol -- 17 Uterine DNA Polymerase: Acquisition of Responsiveness to Estrogen during Postnatal Development of the Rat -- 18 The Artificially Stimulated
Decidual Cell Reaction in the Mouse Uterus: Studies of RNA Polymerases and Histone Modifications -- VI: Blastocyst-Uterine Interactions -- 19 Embryonic Signals and Maternal Recognition -- 20 Uterine Blastotoxic Factors -- 21 Lysosomal
Mechanisms in Blastocyst Implantation and Early Decidualization -- VII: Mechanisms of Implantation -- 22 The Role of Prostaglandins in Endometrial Vascular Changes at Implantation -- 23 Comparison of Implantation in Utero and in Vitro
-- 24 Time-Lapse Cinematography of Mouse Embryo Development from Blastocyst to Early Somite Stage -- VIII: Short Communications -- 1. The Effects of Estradiol-17 ? and Progesterone on the Volume of Uterine Fluid in Ovariectomized Mice
-- 2. Presence of hCG-like Material in the Preimplantation Rabbit Blastocyst -- 3. Electron Microscopic Study of Rat ? Mouse Chimeric Blastocysts Produced by Embryo Aggregation -- 4. Characteristics of an Endogenous Inhibitor of
Progesterone Binding in Rat Trophoblast -- 5. Histone Synthesis in Preimplantation Mouse Embryos -- 6. Use of Concanavalin A to Monitor Changes in Glycoprotein Synthesis during Early Mouse Development -- 7 The Role of Glycoproteins in
the Development of Preimplantation Mouse Embryos -- 8. The Role of Blastolemmase in Implantation Initiation in the Rabbit -- 9. Estradiol-17 ? Dehydrogenase in Rat Endometrium at the Time of Implantation -- 10. The Pig Uterus Secretes
a Progesterone-Induced Inhibitor of Plasminogen Activator -- 11. Role of a Uterine Endopeptidase in the Implantation Process of the Rat -- 12. The Role of Prostaglandins and Cyclic Nucleotides in the Artificially Stimulated Decidual
Cell Reaction in the Mouse Uterus -- 13. Inhibitory Effect of Indomethacin on Nuclear Binding of Progesterone in the Uterus and on Differentiation of Decidual Cells in Culture -- 14 Maternal Recognition of Pregnancy in Swine -- 15
Effects of Preimplantation Bovine and Porcine Conceptuses on Blood Flow and Steroid Content of the Uterus -- 16. Effects of Nicotine on Conceptus Cell Proliferation and Oviductal/Uterine Blood Flow in the Rat -- 17. The Uterine
Epithelium as a Transducer for the Triggering of Decidualization in the Rat -- 18. Cellular Contact between the Trophoblast and the Endometrium at Implantation in the Ewe -- 19. Cell Motility and the Distribution ofActin and Myosin
during Mouse Trophoblast Development in Vitro -- 20. Autoradiographic Studies of Mouse Uterine Glands during the Periimplantation Period -- 21 In Vitro Attachment and Outgrowth of Mouse Trophectoderm -- 22. Hormone Production by Rat
Blastocysts and Midpregnancy Trophoblasts in Vitro -- 23. Separation and Characterization of Endocervical Cells -- 24. Role of the Major Histocompatibility Complex in the Timing of Early Mammalian Development -- 25.
Pregnancy-Associated Endometrial Protein in Women -- 26. Survival of Rat Blastocysts in the Uterus of the Mouse Following Xenogeneic Implantation -- 27. Concanavalin-A-Binding Capacity of Preimplantation Mouse Embryos -- 28. The Use of
Pharmacological Agents to Study Implantation -- Participants
ISBN:9781461331803
Series:eBooks
Series:SpringerLink (Online service)
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Keywords: Physics , Atoms , Physics , Atomic, Molecular, Optical and Plasma Physics
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Call number:SPRINGER-1979-9783642931307:ONLINE Show nearby items on shelf
Title:Systems Theory in Immunology Proceedings of the Working Conference, Held in Rome, May 1978
Author(s):
Date:1979
Size:1 online resource (277 p.)
Note:10.1007/978-3-642-93130-7
Contents:I. Antigenic Stimulation -- Mechanism of B Lymphocyte Activation -- Clonal Dominance: Presentation of Antigenic Subsites is the Determining Factor -- Hierarchic Immunogenicity of Protein Determinants -- Control of B Lymphocyte
Activation through Reversible Binding of Multivalent Antigen: a Simple Model -- II. Cell Interactions -- Some Cellular Interactions Involved in the Primary Immune Response -- Some Models for the Interaction between Cells of the Immune
Systems -- Stimulation of Memory Cells and Abrogation of Suppression with a Mobile Antigen — laden Cell -- Involvement of the Fc Receptor in Immune Regulation: a Hypothesis -- III. Evaluation and Evolution of Antibody Production --
Problems in the Evaluation of Antibody Affinity Distribution during the Immune Response -- Biological Variations of IgM Antibody Affinity -- Speculations on some Fundamental Aspects of the Regulation of the Quantity and Affinity of
Antibody Produced during an Immune Response -- IV. Mathematical Modeling in Immunology -- Deterministic and Stochastic Bounded Rate Models in Immunology -- Some Basic Properties of Stochastic Population Models -- Systems
Compartmentation in Immunological Modeling -- A Mathematical Model of the “Two Signal” Theory for T-B Cells Cooperation -- V. The Network Approach -- Idiotypic Regulation and H2 Restriction -- Immunoglobulin Gene Suppression and
Expression -- Complexity and Regulation of the Immune System: the Network Approach -- The Stability of the Immune Network -- A Mathematical Model of the Stable States of a Network Theory of Self-Regulation -- Approaches for Data
Reduction in Biological Networks
ISBN:9783642931307
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Biomathematics: 32
Keywords: Mathematics , Mathematics , Mathematics, general
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Call number:SPRINGER-1975-9781468426311:ONLINE Show nearby items on shelf
Title:Biology of Aging and Development
Author(s):
Date:1975
Size:1 online resource (344 p.)
Note:10.1007/978-1-4684-2631-1
Contents:Session I Theoretical Concepts of Developmental and Age Changes -- Implications of aging research for society -- Current theories of biological aging -- Towards a theory of development -- Session II Gene Regulation in Differentiation
and Development -- Introductory remarks -- Surface reorganization as an initial inductive event in the differentiation of prothymocytes to thymocytes -- Germ line basis for antibody diversity -- Sequential expression of germ line genes
in development of immunoglobulin class diversity -- Normal and altered phenotypic expression of immunoglobulin genes -- Expression of specific clones during B cell development -- Session III Finite Versus Infinite Proliferative and
Functional Capacities of Cells -- Growth and death of diploid and transformed human fibroblasts -- Pathological implications of cell aging in vitro -- Unlimited division potential of precancerous mouse mammary cells after spontaneous
or carcinogen-induced transformation -- Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy -- Hayflick’s hypothesis: an approach to in vivo testing -- Contributions of cytoplasmic factors
to in vitro cellular senescence -- Session IV Aging of Homeostatic Control Systems -- Introductory remarks -- Age-related changes in thermoregulatory capacity of tryptophan-deficient rats -- Zinc deficiency and brain development in the
rat -- Neuronal—glial interactions during development and aging -- Pituitary inhibitor of thyroxine -- Bioenergetic functions of sleep and activity rhythms and their possible relevance to aging -- Changes in monoamine oxidase and
monoamines with human development and aging -- Procaine HCl (Gerovital H3): a weak, reversible, fully competitive inhibitor of monoamine oxidase -- Discussion of papers on aging of homeostatic control systems -- Session V Development
and Aging in Organ Systems -- Ontogeny of mouse T-lymphocyte function -- Differentiation of thymus cells -- Development of B lymphocytes -- Ontogeny of B-lymphocyte function with respect to the heterogeneity of antibody affinity --
Effects of aging on the differentiation and proliferation potentials of cells of the immune system -- Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice -- Panel discussion on
T-cell heterogeneity -- Session VI Development and Aging at the Molecular Level -- Development and aging at the molecular level -- Hormonal regulation of hepatic P-enolpyruvate carboxykinase (GTP) during development -- Pre- and
postnatal enzyme capacity for drug metabolite production -- Impaired hormonal regulation of enzyme activity during aging -- Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive
responsiveness -- Covalent modification of nuclear proteins during aging -- Effects of aging on ionic movements of atrial muscle -- Enzymatic studies on the skeletal myosin A and actomyosin of aging rats
ISBN:9781468426311
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Faseb Monographs : 3
Keywords: Medicine , Geriatrics , Medicine & Public Health , Geriatrics/Gerontology
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