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SPIRES-BOOKS: FIND KEYWORD HUMAN GENETICS *END*INIT* use /tmp/qspiwww.webspi1/9515.47 QRY 131.225.70.96 . find keyword human genetics ( in books using www Cover
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Call number:9783319520452:ONLINE Show nearby items on shelf
Title:Information Geometry and Population Genetics The Mathematical Structure of the Wright-Fisher Model
Author(s): Julian Hofrichter
Date:2017
Size:1 online resource (XII, 320 p. 3 illus., 2 illus. in color p.)
Contents:1. Introduction -- 2. The Wright–Fisher model -- 3. Geometric structures and information geometry -- 4. Continuous approximations -- 5. Recombination -- 6. Moment generating and free energy functionals -- 7. Large deviation theory --
8. The forward equation -- 9. The backward equation -- 10.Applications -- Appendix -- A. Hypergeometric functions and their generalizations -- Bibliography
ISBN:9783319520452
Series:eBooks
Series:Springer eBooks
Series:Springer 2017 package
Keywords: Mathematics , Human genetics , Mathematical analysis , Analysis (Mathematics) , Geometry , Probabilities , Biomathematics , Statistics , Mathematics , Mathematical and Computational Biology , Statistical Theory and Methods , Human Genetics , Analysis , Geometry , Probability Theory and Stochastic Processes
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Call number:SPRINGER-2014-9783319072128:ONLINE Show nearby items on shelf
Title:Statistical Analysis of Next Generation Sequencing Data [electronic resource]
Author(s): Somnath Datta
Dan Nettleton
Date:2014
Publisher:Cham : Springer International Publishing : Imprint: Springer
Size:1 online resource
Note:Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. Toextract signals from high-d imensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians workingwith NGS data. The topics range from basic prepr ocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn aboutthis growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected todeal with genomic data in basic biomedical research, genomic clinical trials and personalize d medicine. About the editors: Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville.He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics, and Elec ted Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics,Biostatistics and Bioinformatics. Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University. He is Fellow of the American Statistical Associationand has published research on a variety of topics in statistics, biology, and bioinformatics
Contents:Statistical Analyses of Next Generation Sequencing Data: An Overview
Using RNA
seq Data to Detect Differentially Expressed Genes
Differential Expression Analysis of Complex RNA
seq Experiments Using edgeR
Analysis of Next Generation Sequencing Data Using Integrated Nested Laplace Approximation (INLA)
Design of RNA Sequencing Experiments
Measurement, Summary, and Methodological Variation in RNA
sequencing
Functional PCA for differential expression testing with RNA
seq data
Mapping of Expression Quantitative Trait Loci using RNA
seq Data
The Role of Spike
In Standards in
ISBN:9783319072128
Series:eBooks
Series:SpringerLink
Series:Frontiers in Probability and the Statistical Sciences
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Oncology , Human genetics
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Call number:SPRINGER-2014-9781461494430:ONLINE Show nearby items on shelf
Title:Design, Analysis, and Interpretation of Genome-Wide Association Scans [electronic resource]
Author(s): Daniel O Stram
Date:2014
Publisher:New York, NY : Springer New York : Imprint: Springer
Size:1 online resource
Note:This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given tothe practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fieldsthe tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides acompendium of well-established statistical methods based upon singl e SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, isquickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its futureapplications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformaticstools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects
Contents:Introduction to Genome
Wide Association Studies
Topics of Quantitative Genetics
An Introduction to Association Studies
Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation
Haplotype Imputation for Association Analysis
SNP Imputation for Association Studies
Design of Large
scale Genetic Association Studies, Sample Size and Power
Post
GWAS Analyses
ISBN:9781461494430
Series:eBooks
Series:SpringerLink
Series:Statistics for Biology and Health, 1431-8776
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Human genetics , Mathematical statistics
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Call number:SPRINGER-2011-9783642205842:ONLINE Show nearby items on shelf
Title:Permutation Testing for Isotonic Inference on Association Studies in Genetics [electronic resource]
Author(s): Luigi Salmaso
Rosa Arboretti
Livio Corain
Dario Mazzaro
Date:2011
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:

.

Note:Springer eBooks
Contents:Introduction
Association Studies in Genetics
The Nonparametric Permutation Methodology
Statistical Problems of Allelic Association
Power and Sample Size Simulations
Case Study
Conclusions
References
ISBN:9783642205842
Series:e-books
Series:SpringerLink (Online service)
Series:SpringerBriefs in Statistics
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Human genetics , Biotechnology , Pharmacy , Cytology Research_xMethodology , Psychometrics
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Call number:SPRINGER-2011-9781441973382:ONLINE Show nearby items on shelf
Title:The Fundamentals of Modern Statistical Genetics [electronic resource]
Author(s): Nan M Laird
Date:2011
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendels first experiments to genome-wideassociation studies, the book de scribes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation,linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intendedaudience is statisticians, biostatisticians, epidemiologists and quantitatively- orien ted geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or topursue research in methodology. A background in intermediate level statistical methods is required. The aut hors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels.No background in genetics is assumed. Dr. Laird is a Professor of Biostatistics in the Biostatistics Department at the Harvard Sc hool of Public Health. Dr. Laird has contributed to methodology in many different fields, includingmissing data, EM-algorithm, meta-analysis, statistical genetics, and has coauthored a book with Garrett Fitzmaurice and James Ware on Applied Longitudinal A nalysis. She is the recipient of many awards and prizes, including Fellow ofthe American Statistical Association, the American Association for the Advancement of Science, the Florence Nightingale Award, and the Janet Norwood Award. Dr. Lange is an Associa te Professor in the Biostatistics Department at theHarvard School of Public Health. After his PhD in Statistics at the University of Reading (UK), he has worked extensively in the field of statistica
Note:Springer eBooks
Contents:Introduction to statistical genetics and background in molecular genetics
Principles of inheritance: mendel's laws and genetic models
Some basic concepts from population genetics
Aggregation, heritability and segregation analysis: modeling genetic inheritance without genetic data
The general concepts of gene mapping: Linkage, association, linkage disequilibrium and marker maps
Basic concepts of linkage analysis
The basics of genetic association analysis
Population substructure in association studies
Association analysis in family designs
Advanced topics
Genome wid
ISBN:9781441973382
Series:e-books
Series:SpringerLink (Online service)
Series:Statistics for Biology and Health, 1431-8776
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Human genetics , Epidemiology , Biometrics , Statistical methods
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Call number:SPRINGER-2010-9783642114434:ONLINE Show nearby items on shelf
Title:Reaction-Transport Systems [electronic resource] : Mesoscopic Foundations, Fronts, and Spatial Instabilities
Author(s): Werner Horsthemke
Sergei Fedotov
Vicenc Mendez
Date:2010
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book is an introduction to the dynamics of reaction-diffusion systems, with a focus on fronts and stationary spatial patterns. Emphasis is on systems that are non-standard in the sense that either the transport is not simplyclassical diffusion ( Brownian motion) or the system is not homogeneous. A important feature is the derivation of the basic phenomenological equations from the mesoscopic system properties. Topics addressed include transport withinertia, described by persistent random walks an d hyperbolic reaction-transport equations and transport by anomalous diffusion, in particular subdiffusion, where the mean square displacement grows sublinearly with time. In particularreaction-diffusion systems are studied where the medium is in turn eit her spatially inhomogeneous, compositionally heterogeneous or spatially discrete. Applications span a vast range of interdisciplinary fields and the systemsconsidered can be as different as human or animal groups migrating under external influences, popul ation ecology and evolution, complex chemical reactions, or networks of biological cells. Several chapters treat these applications indetail
Note:Springer eBooks
Contents:Reaction Kinetics
Reactions and Transport: Diffusion Inertia, and Subdiffusion
Random Walks and Mesoscopic Reaction
Transport Equations
Reaction
Diffusion Fronts
Reaction
Transport Fronts Propagating into Unstable States
Reaction
Diffusion Fronts in Complex Structures
Ecological Applications
Biomedical Applications
Persistence and Extinction of Populations in Finite Domains
Turing Instabilities in Homogeneous Systems
Turing Instabilities in Reaction
Diffusion Systems With Temporally or Spatially Varying Parameters
Chemical and Biological Applications of Turing
ISBN:9783642114434
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Synergetics, 0172-7389
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Chemical engineering , Ecology , Genetics Mathematics
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Call number:SPRINGER-2010-9781441971654:ONLINE Show nearby items on shelf
Title:Applied Probability [electronic resource]
Author(s): Kenneth Lange
Date:2010
Edition:Second
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Applied Probability presents a unique blend of theory and applications, with special emphasis on mathematical modeling, computational techniques, and examples from the biological sciences. It can serve as a textbook for graduatestudents in applied ma thematics, biostatistics, computational biology, computer science, physics, and statistics. Readers should have a working knowledge of multivariate calculus, linear algebra, ordinary differential equations, andelementary probability theory. Chapter 1 revi ews elementary probability and provides a brief survey of relevant results from measure theory. Chapter 2 is an extended essay on calculating expectations. Chapter 3 deals with probabilisticapplications of convexity, inequalities, and optimization theory. Chapters 4 and 5 touch on combinatorics and combinatorial optimization. Chapters 6 through 11 present core material on stochastic processes. If supplemented withappropriate sections from Chapters 1 and 2, there is sufficient material for a traditional se mester-long course in stochastic processes covering the basics of Poisson processes, Markov chains, branching processes, martingales, anddiffusion processes. The second edition adds two new chapters on asymptotic and numerical methods and an appendix that separates some of the more delicate mathematical theory from the steady flow of examples in the main text. Besidesthe two new chapters, the second edition includes a more extensive list of exercises, many additions to the exposition of combinatorics, new material on rates of convergence to equilibrium in reversible Markov chains, a discussion ofbasic reproduction numbers in population modeling, and better coverage of Brownian motion. Because many chapters are nearly self-contained, mathematical scientist s from a variety of backgrounds will find Applied Probability useful as areference. Kenneth Lange is the Rosenfeld Professor of Computational Genetics in the Departments of Biomathematics and Human Gene
Note:Springer eBooks
Contents:Basic Notions of Probability Theory
Calculation of Expectations
Convexity, Optimization, and Inequalities
Combinatorics
Combinatorial Optimization
Poisson Processes
Discrete
Time Markov Chains
Continuous
Time Markov Chains
Branching Processes
Martingales
Diffusion Processes
Asymptotic Methods
Numerical Methods
Poisson Approximation
Number Theory
Appendix: Mathematical Review
ISBN:9781441971654
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Texts in Statistics, 1431-875X : v0
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Computer science , Computer simulation , Biology Mathematics , Computer science Mathematics , Distribution (Probability theory) , Mathematical statistics
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Call number:SPRINGER-2010-9781441959454:ONLINE Show nearby items on shelf
Title:Numerical Analysis for Statisticians [electronic resource]
Author(s): Kenneth Lange
Date:2010
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Every advance in computer architecture and software tempts statisticians to tackle numerically harder problems. To do so intelligently requires a good working knowledge of numerical analysis. This book equips students to crafttheir own software and t o understand the advantages and disadvantages of different numerical methods. Issues of numerical stability, accurate approximation, computational complexity, and mathematical modeling share the limelight in abroad yet rigorous overview of those parts of numerical analysis most relevant to statisticians. In this second edition, the material on optimization has been completely rewritten. There is now an entire chapter on the MM algorithm inaddition to more comprehensive treatments of constrained optimizati on, penalty and barrier methods, and model selection via the lasso. There is also new material on the Cholesky decomposition, Gram-Schmidt orthogonalization, the QRdecomposition, the singular value decomposition, and reproducing kernel Hilbert spaces. The discussions of the bootstrap, permutation testing, independent Monte Carlo, and hidden Markov chains are updated, and a new chapter on advancedMCMC topics introduces students to Markov random fields, reversible jump MCMC, and convergence analysis in Gibb s sampling. Numerical Analysis for Statisticians can serve as a graduate text for a course surveying computationalstatistics. With a careful selection of topics and appropriate supplementation, it can be used at the undergraduate level. It contains enough material for a graduate course on optimization theory. Because many chapters are nearlyself-contained, professional statisticians will also find the book useful as a reference. Kenneth Lange is the Rosenfeld Professor of Computational Genetics in the Dep artments of Biomathematics and Human Genetics and the Chair of theDepartment of Human Genetics, all in the UCLA School of Medicine. His research interests include human genetics, population modeling, bi
Note:Springer eBooks
Contents:Recurrence Relations
Power Series Expansions
Continued Fraction Expansions
Asymptotic Expansions
Solution of Nonlinear Equations
Vector and Matrix Norms
Linear Regression and Matrix Inversion
Eigenvalues and Eigenvectors
Singular Value Decomposition
Splines
Optimization Theory
The MM Algorithm
The EM Algorithm
Newtons Method and Scoring
Local and Global Convergence
Advanced Optimization Topics
Concrete Hilbert Spaces
Quadrature Methods
The Fourier Transform
The Finite Fourier Transform
Wavelets
Generating Random Deviates
Inde
ISBN:9781441959454
Series:e-books
Series:SpringerLink (Online service)
Series:Statistics and Computing, 1431-8784
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Mathematical statistics
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Call number:SPRINGER-2008-9780387759654:ONLINE Show nearby items on shelf
Title:Statistical Design [electronic resource]
Author(s): George Casella
Date:2008
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Although statistical design is one of the oldest branches of statistics, its importance is ever increasing, especially in the face of the data flood that often faces statisticians. It is important to recognize the appropriatedesign, and to understand how to effectively implement it, being aware that the default settings from a computer package can easily provide an incorrect analysis. The goal of this book is to describe the principles that drive gooddesign, paying attention to both the theoretical b ackground and the problems arising from real experimental situations. Designs are motivated through actual experiments, ranging from the timeless agricultural randomized complete block,to microarray experiments, which naturally lead to split plot designs and balanced incomplete blocks. George Casella is Distinguished Professor in the Department of Statistics at the University of Florida. He is active in many aspectsof statistics, having contributed to theoretical statistics in the areas of decision theory and statistical confidence, to environmental statistics, and has more recently concentrated efforts in statistical genomics. He also maintainsactive research interests in the theory and application of Monte Carlo and other computationally intensive metho ds. He is listed as an ISI Highly Cited Researcher. In other capacities, Professor Casella has served as Theory andMethods Editor of the Journal of the American Statistical Association, 1996-1999, Executive Editor of Statistical Science, 2001-2004, and Co -Editor of the Journal of the Royal Statistical Society, Series B, 2009-2012. He has served onthe Board of Mathematical Sciences of the National Research Council, 1999-2003, and many committees of both the American Statistical Association and the Institut e of Mathematical Statistics. Professor Casella has co-authored fivetextbooks: Variance Components, 1992 Theory of Point Estimation, Second Edition, 1998 Monte Carlo Statistical Methods, Second Edit
Note:Springer eBooks
Contents:Basics
Completely randomized designs
Complete block designs
Interlude: assessing the effects of blocking
Split plot designs
Confounding in blocks
ISBN:9780387759654
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Texts in Statistics, 1431-875X
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Human genetics , Plant breeding , Morphology (Animals) , Mathematical statistics
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Call number:SPRINGER-2004-9781461302179:ONLINE Show nearby items on shelf
Title:Applied Bayesian Statistical Studies in Biology and Medicine
Author(s):
Date:2004
Size:1 online resource (258 p.)
Note:10.1007/978-1-4613-0217-9
Contents:1. Some reflections on the current state of statistics -- 2. Answering two biological questions with a latent class model via MCMC applied to capture-recapture data -- 3. On the Bayesian inference of the Hardy-Weinberg equilibrium
model -- 4. Identifying a Bayesian Network for the problem “Hospital and families: the analysis of patient satisfaction with their stay in hospital” -- 5. Reliability of GIST diagnosis based on partial information -- 6. Comparing two
groups or treatments-a Bayesian approach -- 7. Two experimental settings in clinical trials: predictive criteria for choosing the sample size in interval estimation -- 8. Attributing a paleoanthropological specimen to a prehistoric
population: a Bayesian approach with multivariate B-spline functions -- 9. An example of the subjectivist statistical method for learning from data: Why do whales strand when they do? -- 10. Development and communication of Bayesan
methodology for medical device clinical trials -- 11. An adaptive SIR algorithm for Bayesian multilevel inference on categorical data -- 12. Age at death diagnosis by cranial suture obliteration: a Bayesian approach -- 13. Bayesian
estimation of restriction fragment length from electrophoretic analysis
ISBN:9781461302179
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Statistics , Human genetics , Public health , Biomathematics , Anthropology , Statistics , Statistics for Life Sciences, Medicine, Health Sciences , Public Health , Mathematical and Computational Biology , Anthropology , Human Genetics
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Call number:SPRINGER-2004-9780387218229:ONLINE Show nearby items on shelf
Title:Mathematical Population Genetics I. Theoretical Introduction
Author(s): Warren J Ewens
Date:2004
Edition:Second Edition
Size:1 online resource (418 p.)
Note:10.1007/978-0-387-21822-9
Contents:1 Historical Background -- 1.1 Biometricians, Saltationists and Mendelians -- 1.2 The Hardy-Weinberg Law -- 1.3 The Correlation Between Relatives -- 1.4 Evolution -- 1.5 Evolved Genetic Phenomena -- 1.6 Modelling -- 1.7 Overall
Evolutionary Theories -- 2 Technicalities and Generalizations -- 2.1 Introduction -- 2.2 Random Union of Gametes -- 2.3 Dioecious Populations -- 2.4 Multiple Alleles -- 2.5 Frequency-Dependent Selection -- 2.6 Fertility Selection --
2.7 Continuous-Time Models -- 2.8 Non-Random-Mating Populations -- 2.9 The Fundamental Theorem of Natural Selection -- 2.10 Two Loci -- 2.11 Genetic Loads -- 2.12 Finite Markov Chains -- 3 Discrete Stochastic Models -- 3.1 Introduction
-- 3.2 Wright-Fisher Model: Two Alleles -- 3.3 The Cannings (Exchangeable) Model: Two Alleles -- 3.4 Moran Models: Two Alleles -- 3.5 K-Allele Wright-Fisher Models -- 3.6 Infinitely Many Alleles Models -- 3.7 The Effective Population
Size -- 3.8 Frequency-Dependent Selection -- 3.9 Two Loci -- 4 Diffusion Theory -- 4.1 Introduction -- 4.2 The Forward and Backward Kolmogorov Equations -- 4.3 Fixation Probabilities -- 4.4 Absorption Time Properties -- 4.5 The
Stationary Distribution -- 4.6 Conditional Processes -- 4.7 Diffusion Theory -- 4.8 Multi-dimensional Processes -- 4.9 Time Reversibility -- 4.10 Expectations of Functions of Diffusion Variables -- 5 Applications of Diffusion Theory --
5.1 Introduction -- 5.2 No Selection or Mutation -- 5.3 Selection -- 5.4 Selection: Absorption Time Properties -- 5.5 One-Way Mutation -- 5.6 Two-Way Mutation -- 5.7 Diffusion Approximations and Boundary Conditions -- 5.8 Random
Environments -- 5.9 Time-Reversal and Age Properties -- 5.10 Multi-Allele Diffusion Processes -- 6 Two Loci -- 6.1 Introduction -- 6.2 Evolutionary Properties of Mean Fitness -- 6.3 Equilibrium Points -- 6.4 Special Models -- 6.5
Modifier Theory -- 6.6 Two-Locus Diffusion Processes -- 6.7 Associative Overdominance and Hitchhiking -- 6.8 The Evolutionary Advantage of Recombination -- 6.9 Summary -- 7 Many Loci -- 7.1 Introduction -- 7.2 Notation -- 7.3 The
Random Mating Case -- 7.4 Non-Random Mating -- 7.5 The Correlation Between Relatives -- 7.6 Summary -- 8 Further Considerations -- 8.1 Introduction -- 8.2 What is Fitness? -- 8.3 Sex Ratio -- 8.4 Geographical Structure -- 8.5 Age
Structure -- 8.6 Ecological Considerations -- 8.7 Sociobiology -- 9 Molecular Population Genetics: Introduction -- 9.1 Introduction -- 9.2 Technical Comments -- 9.3 Infinitely Many Alleles Models: Population Properties. -- 9.4
Infinitely Many Sites Models: Population Properties -- 9.5 Sample Properties of Infinitely Many Alleles Models. -- 9.6 Sample Properties of Infinitely Many Sites Models -- 9.7 Relation Between Infinitely Many Alleles and Infinitely
Many Sites Models -- 9.8 Genetic Variation Within and Between Populations -- 9.9 Age-Ordered Alleles: Frequencies and Ages -- 10 Looking Backward in Time: The Coalescent -- 10.1 Introduction -- 10.2 Competing Poisson and Geometric
Processes -- 10.3 The Coalescent Process -- 10.4 The Coalescent and Its Relation to Evolutionary Genetic Models -- 10.5 Coalescent Calculations: Wright-Fisher Models -- 10.6 Coalescent Calculations: Exact Moran Model Results -- 10.7
General Comments -- 10.8 The Coalescent and Human Genetics -- 11 Looking Backward: Testing the Neutral Theory -- 11.1 Introduction -- 11.2 Testing in the Infinitely Many Alleles Models -- 11.3 Testing in the Infinitely Many Sites
Models -- 12 Looking Backward in Time: Population and Species Comparisons -- 12.1 Introduction -- 12.2 Various Evolutionary Models -- 12.3 Some Implications -- 12.4 Statistical Procedures -- Appendix A: Eigenvalue Calculations --
References -- Author Index
ISBN:9780387218229
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Interdisciplinary Applied Mathematics: 27
Keywords: Life sciences , Biochemistry , Evolutionary biology , Applied mathematics , Engineering mathematics , Biomathematics , Life Sciences , Biochemistry, general , Applications of Mathematics , Evolutionary Biology , Genetics and Population Dynamics , Mathematical and Computational Biology
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Call number:SPRINGER-2003-9789401715065:ONLINE Show nearby items on shelf
Title:Evolution of Biological Systems in Random Media: Limit Theorems and Stability
Author(s): Anatoly Swishchuk
Date:2003
Size:1 online resource (218 p.)
Note:10.1007/978-94-017-1506-5
Contents:1 Random Media -- 2 Limit Theorems for Difference Equations in Random Media -- 3 Epidemic Models -- 4 Genetic Selection Models -- 5 Branching Models -- 6 Demographic Models -- 7 Logistic Growth Models -- 8 Predator-Prey Models
ISBN:9789401715065
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Mathematical Modelling: Theory and Applications: 18
Keywords: Mathematics , Human genetics , Epidemiology , Probabilities , Biomathematics , Population , Mathematics , Mathematical and Computational Biology , Probability Theory and Stochastic Processes , Epidemiology , Human Genetics , Population Economics
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Call number:SPRINGER-2003-9783662050927:ONLINE Show nearby items on shelf
Title:Biochips Technology and Applications
Author(s):
Date:2003
Size:1 online resource (134 p.)
Note:10.1007/978-3-662-05092-7
Contents:Oligonucleotide Array Technologies for Gene Expression Profiling -- Medical Therapy: The Next Frontier of Biochip and Biomedical Nanotechnology -- Photobonding of Biomolecules for Biochip Manufacturing -- Opportunities and Obstacles
to the Routine Implementation of Microchips -- DNA Microarray Analysis of Gene Expression Profiles in Hepatocellular Carcinoma -- DNA Hybridization Detection by Electrochemical Impedance Spectroscopy and Photoelectrochemistry -- Data
Mining: An Integrated Approach for Drug Discovery -- Protein Array Detection with Nanoparticle Fluorescent Probes by Laser Confocal Scanning Fluorescence Detection -- Trends in Microfluidic Devices for Analytical Chemistry
ISBN:9783662050927
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Human genetics , Proteomics , Biophysics , Biological physics , Physical measurements , Measurement , Biomedical engineering , Nanotechnology , Physics , Biophysics and Biological Physics , Human Genetics , Biomedical Engineering , Proteomics , Nanotechnology , Measurement Science and Instrumentation
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Call number:SPRINGER-2003-9780387216799:ONLINE Show nearby items on shelf
Title:The Analysis of Gene Expression Data Methods and Software
Author(s):
Date:2003
Size:1 online resource (46 p.)
Note:10.1007/b97411
Contents:The Analysis of Gene Expression Data: An Overview of Methods and Software -- Visualization and Annotation of Genomic Experiments -- Bioconductor R Packages for Exploratory Analysis and Normalization of cDNA Microarray Data -- An R
Package for Analyses of Affymetrix Oligonucleotide Arrays -- DNA-Chip Analyzer (dChip) -- Expression Profiler -- An S-PLUS Library for the Analysis and Visualization of Differential Expression -- Dragon and Dragon View: Methods for the
Annotation, Analysis, and Visualization of Large-Scale Gene Expression Data -- Snomad: Biologist-Friendly Web Tools for the Standardization and NOrmalization of Microarray Data -- Microarray Analysis Using the MicroArray Explorer --
Parametric Empirical Bayes Methods for Microarrays -- SAM Thresholding and False Discovery Rates for Detecting Differential Gene Expression in DNA Microarrays -- Adaptive Gene Picking with Microarray Data: Detecting Important Low
Abundance Signals -- MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments -- GeneClust -- POE: Statistical Methods for Qualitative Analysis of Gene Expression -- Bayesian Decomposition -- Bayesian
Clustering of Gene Expression Dynamics -- Relevance Networks: A First Step Toward Finding Genetic Regulatory Networks Within Microarray Data
ISBN:9780387216799
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Statistics , Human genetics , Mathematical statistics , Biochemistry , Bioinformatics , Probabilities , Statistics , Statistics for Life Sciences, Medicine, Health Sciences , Probability Theory and Stochastic Processes , Biochemistry, general , Human Genetics , Bioinformatics , Probability and Statistics in Computer Science
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Call number:SPRINGER-2002-9780387217505:ONLINE Show nearby items on shelf
Title:Mathematical and Statistical Methods for Genetic Analysis
Author(s): Kenneth Lange
Date:2002
Edition:Second Edition
Size:1 online resource (370 p.)
Note:10.1007/978-0-387-21750-5
Contents:Basic Principles of Population Genetics -- Counting Methods and the EM Algorithm -- Newton's Method and Scoring -- Hypothesis Testing and Categorical Data -- Genetic Identity Coefficients -- Applications of Identity Coefficients --
Computation of Mendelian Likelihoods -- The Polygenic Model -- Descent Graph Models -- Molecular Phylogeny -- Radiation Hybrid Mapping -- Models of Recombination -- Sequence Analysis -- Poisson Approximation -- Diffusion Processes
ISBN:9780387217505
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Medicine , Human genetics , Statistics , Biomedicine , Human Genetics , Statistics for Life Sciences, Medicine, Health Sciences
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Call number:SPRINGER-1999-9781461547778:ONLINE Show nearby items on shelf
Title:Introduction to Biometry
Author(s): Pierre Jolicoeur
Date:1999
Size:1 online resource (517 p.)
Note:10.1007/978-1-4615-4777-8
Contents:1 Looking at quantitative biological data through scatter diagrams -- 2 Samples and populations, estimates and parameters -- 3 Frequencies and probabilities -- 4 Measures of central tendency and of dispersion -- 5 The normal
distribution -- 6 The distribution of Student’st -- 7 The distribution of?2(chi squared) -- 8 The distribution of the variance ratio, F = S12/S12 -- 9 Hypotheses and confidence intervals concerning one or two means -- 10 Hypotheses and
confidence intervals concerning one variance -- 11 Hypotheses and confidence intervals concerning a variance ratio -- 12 The analysis of variance or “ANOVA” (one-way, type I) -- 13 The skewness and peakedness indicesg1andg2 -- 14 The
lognormal distribution -- 15 Testing hypotheses concerning frequency tables using the X2 distribution -- 16 Tests of goodness of fit -- 17 The binomial distribution -- 18 The Poisson distribution -- 19 The bivariate normal distribution
and the correlation coefficient, r -- 20 Estimation lines (the so-called “regression” lines) -- 21 The analysis of covariance or “ANCOVA”: comparing estimation lines -- 22 The orthogonal estimation line or major axis -- 23 The
trivariate normal distribution: partial and multiple correlations and regressions -- 24 Elementary linear calculations (vectors and matrices) -- 25 Partial and multiple correlations and regressions: matrix calculations -- 26 One-way
type I analysis of variance with contrasts -- 27 One-way type II analysis of variance with variance components -- 28 Two-way type I analysis of variance with interaction -- 29 The multivariate normal distribution -- 30 The distribution
of Hotelling’sT2 -- 31 Principal components orprincipal axes -- 32 Fisher’s linear discriminant function -- 33 Multiple discriminant analysis -- 34 Canonical correlations -- 35 Growth curves and other nonlinear relationships --
Appendices -- The statistical tables most frequently used in biometry -- The standardized normal distribution -- The distribution of x (chi squared) -- Detailed table of contents -- Author index
ISBN:9781461547778
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Mathematics , Human genetics , Epidemiology , Probabilities , Statistics , Mathematics , Probability Theory and Stochastic Processes , Statistics, general , Epidemiology , Human Genetics
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Call number:SPRINGER-1997-9781475727395:ONLINE Show nearby items on shelf
Title:Mathematical and Statistical Methods for Genetic Analysis
Author(s): Kenneth Lange
Date:1997
Size:1 online resource (265 p.)
Note:10.1007/978-1-4757-2739-5
Contents:1 Basic Principles of Population Genetics -- 2 Counting Methods and the EM Algorithm -- 3 Newton’s Method and Scoring -- 4 Hypothesis Testing and Categorical Data -- 5 Genetic Identity Coefficients -- 6 Applications of Identity
Coefficients -- 7 Computation of Mendelian Likelihoods -- 8 The Polygenic Model -- 9 Markov Chain Monte Carlo Methods -- 10 Reconstruction of Evolutionary Trees -- 11 Radiation Hybrid Mapping -- 12 Models of Recombination -- 13 Poisson
Approximation -- Appendix: Molecular Genetics in Brief -- A.l Genes and Chromosomes -- A.2 From Gene to Protein -- A.3 Manipulating DNA -- A.4 Mapping Strategies -- References
ISBN:9781475727395
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Statistics , Human genetics , Biomathematics , Statistics , Statistical Theory and Methods , Mathematical and Computational Biology , Human Genetics
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Call number:SPRINGER-1990-9789400925892:ONLINE Show nearby items on shelf
Title:Fundamentals of Mathematical Evolutionary Genetics
Author(s): Yuri M Svirezhev
Date:1990
Size:1 online resource (396 p.)
Note:10.1007/978-94-009-2589-2
Contents:1. Deterministic Models in Mathematical Genetics -- 1. Brief Outline of Microevolution Theory with Some Facts from Genetics -- 2. Basic Equations of Population Genetics -- 3. Simplest Population Models -- 4. Multiple Alleles -- 5.
Sex-Limited and Sex-Linked Characters. Models Taking Account of Sex Distinctions -- 6. Populations With Deviations from Panmixia -- 7. Systems of Linked Populations. Migration -- 8. Population Dynamics in Changing Environment -- 9.
Multi-Locus Models -- 2. Stochastic Models of Mathematical Genetics -- 10. Diffusion Models of Population Genetics -- 11. Random Genetic Drift in the Narrow Sense -- 12. Properties of Single-Locus Models under Several Microevolutionary
Pressures -- 13. Random Genetic Drift in Subdivided Populations -- Conclusion -- Short Glossary of Genetic Terms
ISBN:9789400925892
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Mathematics and Its Applications, Soviet Series: 22
Keywords: Mathematics , Human genetics , Mathematical models , Statistics , Applied mathematics , Engineering mathematics , Mathematics , Mathematical Modeling and Industrial Mathematics , Human Genetics , Appl.Mathematics/Computational Methods of Engineering , Statistics, general
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Call number:SPRINGER-1990-9789400906198:ONLINE Show nearby items on shelf
Title:Statistics in Science The Foundations of Statistical Methods in Biology, Physics and Economics
Author(s):
Date:1990
Size:1 online resource (200 p.)
Note:10.1007/978-94-009-0619-8
Contents:Method, Theory, and Statistics: The Lesson of Physics -- The Theory of Natural Selection as a Null Theory -- Causality and Exogeneity in econometric models -- Statistics in Expert Resolution: A Theory of Weights for Combining Expert
Opinion -- Short and Long Term Survival Analysis in Oncological Research -- A Statistical Approach to the Study of Pollen Fitness -- Statistics in Genetics: Human Migrations Detected by Multivariate Techniques -- Quantum Probability
and the Foundations of Quantum Theory -- Indistinguishability, Interchangeability and Indeterminism -- The Non Frequency Approach to Elementary Particle Statistics -- Name Index
ISBN:9789400906198
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Boston Studies in the Philosophy of Science: 122
Keywords: Statistics , History , Philosophy and science , Biology , Statistics , Statistics, general , Philosophy of Science , History, general , Philosophy of Biology
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Call number:SPRINGER-1990-9789400905139:ONLINE Show nearby items on shelf
Title:Mathematical and Statistical Developments of Evolutionary Theory
Author(s):
Date:1990
Size:1 online resource (380 p.)
Note:10.1007/978-94-009-0513-9
Contents:The Differential Geometry of Population Genetics and Evolutionary Games -- Topics in the Theory of Ess’s -- Selection in Natural Populations -- Population Genetics Theory - The Past and the Future -- A Discussion of Evolutionarily
Stable Strategies -- Évolution Du Rapport Numérique Des Sexes Et Modèles Dynamiques connexes -- Topics in Evolutionary Ecology
ISBN:9789400905139
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO ASI Series, Series C: Mathematical and Physical Sciences: 299
Keywords: Life sciences , Human genetics , Evolutionary biology , Mathematical models , Statistics , Life Sciences , Evolutionary Biology , Human Genetics , Mathematical Modeling and Industrial Mathematics , Statistics, general
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Call number:SPRINGER-1990-9781468458503:ONLINE Show nearby items on shelf
Title:Genetic Toxicology of Complex Mixtures
Author(s):
Date:1990
Size:1 online resource (384 p.)
Note:10.1007/978-1-4684-5850-3
Contents:Development and Application of New Methodologies Applicable to Research on Complex Environmental Mixtures -- Complex Mixtures of Genotoxicants in Air -- Identification of Genotoxic Agents in Complex Mixtures of Air Pollutants -- Human
Exposure to Airborne Mutagens Indoors and Outdoors Using Mutagenesis and Chemical Analysis Methods -- Genetic Toxicology of Airborne Particulate Matter Using Cytogenetic Assays and Microbial Mutagenicity Assays -- Indoor and Outdoor
Sources of Airborne Mutagens in Nonurban Areas -- Characterization of Mutagen Sources in Urban Particulate Matter in Gothenburg, Sweden -- Assessment of the Mutagenicity of Volatile Organic Air Pollutants Before and After Atmospheric
Transformation -- Carcinogenicity of Complex Mixtures in Air Using In Vitro and In Vivo Assays -- Contribution of Polycyclic Aromatic Hydrocarbons and Other Polycyclic Aromatic Compounds to the Carcinogenicity of Combustion Sources and
Air Pollution -- Old and New Carcinogens -- Experimental and Epidemiologic Applications to Cancer Risk Assessment of Complex Mixtures -- Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood
Combustion in Xuan Wei, China -- The Role of Nitroarenes in the Mutagenicity of Airborne Particles Indoors and Outdoors -- Complex Mixtures of Genotoxicants in Waters -- Characterization of Mutagenic Compounds Formed During
Disinfection of Drinking Water -- Genotoxic and Carcinogenic Properties of Chlorinated Furanones: Important By-products of Water Chlorination -- Assessment and Identification of Genotoxic Compounds in Water -- Methods to Measure
Genotoxins in Wastewater: Evaluation with In Vivo and In Vitro Tests -- Detection of Genotoxicity in Chlorinated or Ozonated Drinking Water Using an Amphibian Micronucleus Test -- Exposure/Effects Assessment -- The Significance of
Mutagenicity as a Criterion in Ecotoxicological Evaluations -- DNA Adducts and Related Biomarkers in Assessing the Risk of Complex Mixtures -- Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein
Adducts -- 32P-Postlabeling DNA Adduct Assay: Cigarette Smoke-induced DNA Adducts in the Respiratory and Nonrespiratory Rat Tissues -- Postlabeling Analysis of Polycyclic Aromatic Hydrocarbon: DNA Adducts in White Blood Cells of
Foundry Workers -- Protein Adducts as Biomarkers for Chemical Carcinogens -- Evaluation of DNA Binding In Vivo for Low-Dose Extrapolation in Chemical Carcinogenesis -- Cancer Risks Due to Occupational Exposure to Polycyclic Aromatic
Hydrocarbons: A Preliminary Report -- Future Directions in Research on the Genetic Toxicology of Complex Mixtures
ISBN:9781468458503
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 39
Keywords: Medicine , Human genetics , Pharmacology , Ecotoxicology , Waste management , Biomedicine , Pharmacology/Toxicology , Human Genetics , Waste Management/Waste Technology , Ecotoxicology
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Call number:SPRINGER-1990-9781468458350:ONLINE Show nearby items on shelf
Title:Bioenergetics Molecular Biology, Biochemistry, and Pathology
Author(s):
Date:1990
Size:1 online resource (484 p.)
Note:10.1007/978-1-4684-5835-0
Contents:Opening Session -- Introductory Remarks -- Opening Lecture -- Special Session -- Memories of My Flavoprotein Research -- I. Biochemistry 1. Mitochondrial Electron Transfer -- An Overview of Ubiquinone Proteins -- Studies on the
Mechanism of Action of the Mitochondrial Energy-Linked Nicotinamide Nucleotide Transhydrogenase -- Structures of Beef Mitochondrial Complex I Subunits -- Inhibition of the Mitochondrial Complex I Activity by Fatty Acid Derivatives of
Vanillylamide -- New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-Ubiquinone Oxidoreductase in the Respiratory Chain II -- Effects of Redox State for Ubiquinone-10 on the Membrane Fluidity of
Cardiolipin-Containing Liposomes -- Features of Assembly and Mechanism of Yeast Mitochondrial Ubiquinol: Cytochrome c Oxidoreductase -- Structural Studies of Euglena Cytochrome c1 -- How Well is Cytochrome c Engineered? -- Subunit I is
the Catalytic Center of P. denitrificans Cytochrome c Oxidase -- The Separation between Cytochrome a and Cytochrome a3 in the Absolute Spectrum -- I. 2. Energy Coupling and Ion Transport -- Which Electron-Transferring Reactions in the
Respiratory Chain Contribute to the Energy Conservation? -- Cytochrome Oxidase and Peroxide Metabolism -- Do Hydrogen Ions Serve as Bioenergetic Messengers in Yeast? -- Molecular Organization and Regulation of the Protonmotive System
of Mammalian ATP Synthase -- Situation of Archaebacterial ATPase among Ion-Translocating ATPases -- Structure and Chemical Modification of Pig Gastric (H++K+)-ATPase -- Inhibition of the Uncoupler-Induced Mitochondrial ATP-Hydrolysis
by the Cooperative Work of the ATPase Inhibitor, 9K Protein and 15K Protein -- Reconstitution of H+ATPase into Planar Phospholipid Bilayers and its Kinetic Analysis -- A Mitochondrial Carrier Family for Solute Transport -- The Calcium
Pump of the Plasma Membrane: Structure/Function Relationships -- I.3. Other Related Topics -- The 9-kDa Polypeptide with Iron-Sulfur Centers A/B in Spinach Photosystem I with Special Reference to its Structure and Topographic
Consideration in Thylakoid Membrane -- A Photo-Signal Transducing Photoreceptor (Stentorin) in Stentor coeruleus: A Brief Review -- Theory and Applications of the Kinetics of Substrate Reaction during Irreversible Modification of
Enzyme Activity -- High Pressure Kinetic Studies on Certain Hemoproteins -- The Purification and Properties of Glycerol-3-Phosphate Dehydrogenase in the Mitochondrial Inner Membrane -- II. Molecular Biology -- Subunit 8 of Yeast
Mitochondrial ATP Synthase: Biochemical Genetics and Membrane Assembly -- Gene Structure of Human ATP Synthase Beta Subunit -- Molecule and Gene of Sulfolobus acidocaldarius ATPase -- Nuclear Genes Encoding Two Subunits of Human
Mitochondrial Cytochrome bc1 Complex, Cytochrome c1 and Ubiquinone-Binding Protein: Their Structural Organization of the 5?-Flanking Regions and Chromosomal Localization -- Studies on the Function of the Mitochondrial Hinge Protein:
Molecular Genetic Approach Using Yeast as a Model System -- Molecular Evolution and Biology of Human Mitochondrial DNA -- III. Mitochondrial Pathology -- Stable and Unstable Bioenergetics in Vivo -- Regulation of Activity and
Tissue-Specific Expression of Cytochrome c Oxidase Genes under Normal and Pathological Conditions -- Mitochondrial DNA Mutations as an Etiology of Human Degenerative Diseases -- Mitochondrial Myopathies: Morphological Approach to
Molecular Abnormalities -- S1 Nuclease Analysis and Direct Sequencing of Deleted Mitochondrial DNA in Myopathic Patients: Role of Directly Repeated Sequences in Deletion -- Thirty Years of Mitochondrial Pathophysiology: From Luft's
Disease to Oxygen Toxicity -- Participants -- Author Index
ISBN:9781468458350
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Biochemistry , Biophysics , Biological physics , Physics , Biophysics and Biological Physics , Biochemistry, general
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Call number:SPRINGER-1984-9781461323990:ONLINE Show nearby items on shelf
Title:Mutation, Cancer, and Malformation
Author(s):
Date:1984
Size:1 online resource (855p p.)
Note:10.1007/978-1-4613-2399-0
Contents:Genetic Factors in Human Diseases -- Environmental mutagenesis and disease in human populations -- Clinical genetics of human cancer -- Chromosome abnormalities in cancer development -- Mutations of cellular oncogenes as a basis for
neoplastic change -- Human gene mapping in the analysis of oncogenes -- Basic Concepts in Mutagenesis and Carcinogenesis -- Relationship between mutagenesis and carcinogenesis -- Theoretical basis of mutagenesis -- DNA repair processes
-- The Role of DNA repair in mutation induction -- Use of the Bacilussubtilus Rec-assay in environmental mutagen studies -- Mutagenesis in yeasts -- A comparison of genotoxic activity in somatic tissue and in the germ cells of
Drosophilamelanogaster -- The P-factor: a transposable element in Drosophila -- Silkworm genetics and chemical mutagenesis -- Mutation induction and detection in Arabidopsis -- Mutagenesis studies with cultured mammalian cells:
problems and prospects -- The control of cell transformation, mutagenesis and differentiation by chemicals that initiate or promote tumor formation -- Dominant-lethal mutations and heritable translocations in mice -- Recessive and
dominant mutations in mice -- Benzo (a)pyrene and 6-nitrobenzo (a) pyrene metabolism in human and rodent microsomes and tissue culture -- Nitrosamine metabolism and carcinogenesis -- Modification of carcinogenesis by dietary and
nutritional factors -- Naturally occurring mutagens -- Reproductive Toxicology -- Teratogenesis -- A possible mechanistic link between teratogenesis and carcinogenesis: inhibited intercellular communication -- Gem cell toxicity:
significance in genetic and fertility effects of radiation and chemicals -- Environmental Toxicology, Mutagenesis, and Carcinogenesis -- The science of toxicology — scope, goals and four case studies -- Mutagenicity of pesticides --
Genetic toxicology of 14 agents casually associated with cancer in humans -- Sensitivity, specificity and accuracy of the Arabidopsis assay in the identification of carcinogens -- Environmental studies in Sweden -- Research progress on
environmental mutagenesis, carcinogenesis and teratogenesis in China -- A. Strategy of approach to cancer control in China -- Toxicological research in public health: the Chinese experience -- Environmental mutagenesis research at
Fudan University -- The role of risk assessment in regulatory decisions in the United States -- Alternate methods for integrated evaluation of toxicity and risk assessment -- Posters
ISBN:9781461323990
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 31
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1983-9783642878930:ONLINE Show nearby items on shelf
Title:Population Biology Proceedings of the International Conference held at the University of Alberta, Edmonton, Canada, June 22–30, 1982
Author(s):
Date:1983
Size:1 online resource (444 p.)
Note:10.1007/978-3-642-87893-0
Contents:I Population Genetics -- The Use of Coefficients of Identity to Study Random Drift -- Instability and Repulsivity of the Fixation States in Biallelic Selection Models -- Microscopic Clustering of Population Processes -- Models for
Peripheral Populations: The Role of Immigration -- A Mathematical Analysis of the Chitty Hypothesis -- An Haploid Model for Genotype-Dependent Population Diffusion -- Further Models of Selection with Antagonistic Pleiotropy --
Algebraic Methods in Genetics -- II Life History Strategies -- The Evolution of Life Histories Under Pleiotropic Constraints and K-Selection -- On the r-K Tradeoff in Density Dependent Selection -- A Test of Ideas About the Evolution
of Efficiencies and Strategies of Resource Use -- Compensatory Strategies of Energy Investment in Uncertain Environments -- A Geometric Model for Optimal Life History -- Necessary Conditions for an Invasion Proof Strategy -- The
Evolution of Stable Strategies -- III Population Growth -- Forecasting the Human Population -- Persistence in Uncertain Environments -- Formulating Population Models with Differential Aging -- Population Modelling by Higher Order
Differential Equations -- Concerning the Time-Dependence of Population Vital Rates -- Extinction Probabilities in Stochastic Age-Structured Models of Population Growth -- The Systematic Formulation of Delay-Differential Models of Age
or Size Structured Populations -- Lotka Distribution for a Finite Mixture of Human Populations I -- A Problem in Nonlinear Age Dependent Population Diffusion -- IV Competitive Systems -- Coexistence of Competitors in a Stochastic
Environment: The Storage Effect -- Invited Guest Lecture: Models of Competition for a Single Resource -- Competitive Predator-Prey Systems and Coexistence -- Coexistence of Many Competing Species -- Competition and Age-Structure --
Selection of Molecular Species by Competition for a Common Source -- An Analysis of Competition Between The Larvae of a Deposit-Feeding and a Filter-Feeding Species of Chironomid (Diptera), Using a Mechanistic Model -- V predator-Prey
Systems -- Invited Guest Lecture: The Dynamics of Host-Parasitoid Interactions with Heterogeneity Host Density Dependence and Variable Sex Ratios -- Some Applications of Coherent State Representation to Nonlinear Bio-Oscillators --
Mathematical Analysis of Some Resource-PreyPredator Models: Application to a NPZ Microcosm Model -- Resonance in Prey-Predator Systems -- A Mathematical Model of Population Regulation in Cyclic Mammals -- Monotone Schemes for Three
Species Prey-Predator Reaction-Diffusion -- Some Age-Structure Effects in Predator-Prey Models -- A Model Predator-Prey System with Mutual Interference and Time Delay -- Oscillations in Prey-Predator Volterra Models -- VI Community
Ecology -- Coevolution -- A Coexistence Model for N-Species Using Nearest Neighbour Interaction and the Role of Diffusion -- Periodic Lotka-Volterra Systems and Time Sharing of Ecological Niches -- Nonobligate and Obligate Models of
Mutualism -- Stability of Community Interaction Matrices -- Biomass Flow, Structure and Stability of Model Ecological Systems -- Is Dynamical Systems Theory the Best Way to Understand Ecosystem Stability? -- Stability in Compartmental
Models -- VII Resource Management -- Invited Guest Lecture: Search Theory in Ecology and Resource Management -- Models of Pheromone Release for Pest Control in which Males Attract Females -- Age- and Size-Specific Models in the
Dungeness Crab Fishery -- Harvesting Under Small Demographic Uncertainty -- Resource Recovery Time: Just How Destabilizing Is It? -- VIII Epidemology and Immunology -- Influence of Infectious Disease on the Growth of a Population with
Three Genotypes -- Interaction of Antitumor Cells: Competition and Interference -- A Model for Infection -- A Cyclic Epidemic Model with Temporary Immunity and Vital Dynamics
ISBN:9783642878930
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Biomathematics: 52
Keywords: Mathematics , Ecology , Biomathematics , Mathematics , Mathematical and Computational Biology , Ecology
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Call number:SPRINGER-1983-9781475796520:ONLINE Show nearby items on shelf
Title:Chemical Signals in Vertebrates 3
Author(s):
Date:1983
Size:1 online resource (368 p.)
Note:10.1007/978-1-4757-9652-0
Contents:One: Reptiles -- Strike-Induced Chemosensory Searching by Rattlesnakes: The Role of Envenomation-Related Chemical Cues in the Post-Strike Environment -- Fossil and Comparative Evidence for Possible Chemical Signaling in the
Mammal-Like Reptiles -- Two: Vomeronasal Organ -- Snake Tongue Flicking Behavior: Clues to Vomeronasal System Functions -- The Accessory Olfactory System: Role in Maintenance of Chemoinvestigatory Behavior -- Flehmen Behavior and
Vomeronasal Organ Function -- Three: Neuroendocrinology of Olfaction -- Olfaction in Central Neural and Neuroendocrine Systems: Integrative Review of Olfactory Representations and Interrelations -- The Neuroendocrinology of Scent
Marking -- Four: Chemical Signals and Endocrines -- Priming Pheromones in Mice -- Pheromonal Control of the Bovine Ovarian Cycle -- Synchronizing Ovarian and Birth Cycles by Female Pheromones -- Volatile and Nonvolatile Chemosignals of
Female Rodents: Differences in Hormonal Regulation -- Five: Chemical Signals and Genetics -- Communication Disparities Between Genetically-Diverging Populations of Deermice -- Six: Field Studies (Pheromone Ecology) -- The Ecological
Importance of the Anal Gland Secretion of Yellow Voles (Lagurus luteus) -- Odor as a Component of Trap Entry Behavior in Small Rodents -- Experimental Modulation of Behavior of Free-Ranging Mammals by Semiochemicals -- Seven: Social
Odors: Discrimination and Recognition -- Mechanisms of Individual Discrimination in Hamsters -- Human Olfactory Communications -- Eight: Chemistry -- Studies of the Chemical Composition of Secretions from Skin Glands of the Rabbit
Oryctolagus cuniculus -- Nine: Pheromones and Other Physiological Functions -- Thermal and Osmolarity Properties of Pheromonal Communication in the Gerbil, Meriones unguiculatus -- Ten: Abstracts -- The Evolution of Alarm Pheromones --
Investigation into the Origin(s) of the Freshwater Attractant(s) of the American Eel -- A Pregnancy Block Resulting from Multiple-Male Copulation or Exposure at the Time of Mating in Deer Mice (Peromyscus maniculatus) -- Olfactory
Communication in Kangaroo Rats (D. merriami) -- Odor Preferences of Young Rats: Production of an Attractive Odor by Males -- Rate and Location of Scent Marking by Pikas During the Breeding Season -- Effects of Urine on the Response to
Carrot-Bait in the European Wild Rabbit -- An Investigation into the ‘Bruce Effect’ in Domesticated Rabbits -- Individual Discrimination on the Basis of Urine in Dogs and Wolves -- Throat-Rubbing in Red Howler Nbnkeys (Alouatta
seniculus) -- Author Index
ISBN:9781475796520
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Atoms , Physics , Atomic, Molecular, Optical and Plasma Physics
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Call number:SPRINGER-1983-9781461337393:ONLINE Show nearby items on shelf
Title:Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk
Author(s):
Date:1983
Size:1 online resource (341 p.)
Note:10.1007/978-1-4613-3739-3
Contents:Session I. Introduction -- How Much Progress this Time? -- Session II. Detection of Specific Locus Mutations in Somatic Cells -- Human Mutagenicity Monitoring: Studies with 6-Thioguanine Resistant Lymphocytes -- Detection of Somatic
Mutants of Hemoglobin -- Counting of RBC Variants Using Rapid Flow Techniques -- Biochemical Approaches to Monitoring Human Populations for Germinal Mutation Rates: II. Enzyme Deficiency Variants as a Component of the Estimated Genetic
Risk -- Session III. Human Monitoring — Detection of Specific Locus Mutations in Germ Cells -- Biochemical Approaches to Monitoring Human Populations for Germinal Mutation Rates: I. Electrophoresis -- Session IV. Utilization of Model
Systems in Mice: Part I -- The Detection of ENU-Induced Mutants in Mice by Electrophoresis and The Problem of Evaluating the Mutation Rate Increase -- Relation of Mouse Specific Locus Tests to Other Mutagenicity Tests and to Risk
Estimation -- The Detection of Induced Recessive Lethal Mutations in Mice -- Session V. Utilization of Model Systems in Mice: Part II -- Using Inversions to Detect and Study Recessive Lethals and Detrimentals in Mice -- Cataracts —
Indicators for Dominant Mutations in Mice and Man -- Applications in Genetic Risk Estimation of Data on the Induction of Dominant Skeletal Mutations in Mice -- Detection of Enzyme Activity Variants in Mice -- Some Factors Affecting the
Mutagenic Response of Mouse Germ Cells to Chemicals -- Session VI. Detailed Analysis of Specific Locus Mutations -- Qualitative Analysis of Mouse Specific-Locus Mutations: Information on Genetic Organization, Gene Expression, and the
Chromosomal Nature of Induced Lesions -- Developmental Genetics of Specific Locus Mutations -- Dominant and Recessive Effects of Electrophoretically Detected Specific Locus Mutations -- Session VII. Future Directions -- Some Ideas on
Future Test Systems -- Problems in Extrapolation of Animal Data to Humans -- Specific Locus Mutations in the Monitoring of Human Populations for Genetic Damage -- Some Research Needs to Support Mutagenicity Risk Assessments from Whole
Mammal Studies -- Contributors
ISBN:9781461337393
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 28
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1980-9783642931611:ONLINE Show nearby items on shelf
Title:Vito Volterra Symposium on Mathematical Models in Biology Proceedings of a Conference Held at the Centro Linceo Interdisciplinare, Accademia Nazionale dei Lincei, Rome December 17 – 21, 1979
Author(s):
Date:1980
Size:1 online resource (418 p.)
Note:10.1007/978-3-642-93161-1
Contents:Topic I Models of Natural Selection -- Models of Natural Selection -- Stochastic Theory of Population Genetics and Evolution -- Natural Selection and Continuous Variation -- Some Models for the Evolution of Adaptive Traits --
Evolutionary Game Theory -- Variability and Permanence in Molecular Genetics -- Evolution in Human Populations: Data and Models -- Models of Density- and Frequency- Dependent Selection for the Exploitation of Resources. II. Coevolution
of Species in Competition -- Intraspecific Competition and Evolution -- Ecological Implications of Natural Selection -- Topic II Problems in Population Biology and Related Disciplines -- Areas of Overlap of Population Genetics with
Related Disciplines -- Completeness and Craft Standards in Ecological Theory -- A Theoretical Approach to the Dynamics of Single Populations -- Stochastic Equations in Neurobiology and Population Biology -- Models for Vector-Borne
Parasitic Diseases -- The Dynamics and Control of Direct Life Cycle Helminth Parasites -- Epidemiologic Models of Bacterial Diseases -- Strategic Planning Models for Rubella Vaccination Programmes -- The Cybernetics of Biological
Macromolecules -- A Pattern Formation Mechanism and its Application to Mammalian Coat Markings -- Cell Growth as an Autocatalytic Relaxation Process -- Vito Volterra and Contemporary Mathematical Biology
ISBN:9783642931611
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Biomathematics: 39
Keywords: Mathematics , Probabilities , Biomathematics , Statistics , Mathematics , Probability Theory and Stochastic Processes , Mathematical and Computational Biology , Statistics for Life Sciences, Medicine, Health Sciences
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Call number:SPRINGER-1977-9783642930713:ONLINE Show nearby items on shelf
Title:Measuring Selection in Natural Populations
Author(s):
Date:1977
Size:1 online resource (566 p.)
Note:10.1007/978-3-642-93071-3
Contents:1. Study of Selection -- Estimation of mating cycle components of selection in plants -- Population genetics of Zoarces viviparus (L.), a review -- A study of sexual selection in natural populations of the milkweed beetle, Tetraopes
tetraophthalmus -- How does the genome congeal? -- Attempts to measure selection by altering gene frequencies in natural populations -- Genetic variance for viability and linkage disequilibrium in natural populations of Drosophila
melanogaster -- Sexual selection and the evolution of territoriality in birds -- Functional aspects of genetic variation -- On conditional inference for deviation from Hardy-Weinberg distribution -- 2. Study of Polymorphism --
Selection and neutrality -- Protein evolution: Nonrandom patterns in related species -- Polymorphism, selection, and multi-locus heterozygosity in the plaice, Pleuronectes platessa L. -- Hidden heterogeneity among electrophoretic
alleles -- Natural selection and the ?-GPDH locus in Drosophilidae -- Nonrandom associations between allozymes in natural populations of Drosophila melanogaster -- Polymorphism for the number of genes coding for salivary amylase in the
bank vole, Clethrionomys glareola -- A geometric formulation of the stability condition at a triallelic locus -- A general model to account for enzyme variation in natural populations. IV The quantitative genetics of viability mutants
-- 3. Sex and Evolution -- The sex habit in plants and animals -- Evolution of the sex ratio in the wood lemming, Myopus schisticolor -- Population genetics, demography and the sex ratio -- A comparative study on enzyme polymorphisms
in sympatric diploid and polyploid populations of Lumbricillus lineatus (O.F.M.), Enchytraeidae, Oligochaeta -- Selection and genetic differentiation in parthogenetic populations -- 4. Ecology and Evolution -- Cactus-breeding
Drosophila — A system for the measurement of natural selection -- Test of the hypothesis that migration balances selection in differentiated subpopulations of Spirorbis borealis -- The selection regime of Philaneus spumarius (L.)
(Homoptera) -- Effects of a virus on competition and selection in barley -- Selection and interspecific competition -- Coevolution in ecological systems: Results from “loop analysis” for purely density-dependent coevolution -- 5. Human
Evolution -- Selection and non-Mendelian variability -- Estimation of the characteristics of rare variants -- The genetics of HLA and disease associations
ISBN:9783642930713
Series:eBooks
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Series:Springer eBooks
Series:Lecture Notes in Biomathematics: 19
Keywords: Medicine , Life sciences , Biomedicine , Biomedicine general , Life Sciences, general
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Call number:SPRINGER-1976-9781461343042:ONLINE Show nearby items on shelf
Title:Molecular and Biological Aspects of the Acute Allergic Reaction
Author(s):
Date:1976
Size:1 online resource (464 p.)
Note:10.1007/978-1-4613-4304-2
Contents:Session I Structure of Allergens and Regulation of IgE Immune Response -- Common Characteristics of Major Allergens -- Allergy: A Model for Studying the Genetics of Human Immune Response -- Induction and Suppression of IgE Antibody
Response -- T Cell-Mediated Regulation of IgE Antibody Production -- Session II IgE In Rats: An Experimental Model -- Production of IgE and Reaginic Antibody in Rats in Relation to Worm Infections -- IgE-Myelomas in Rats -- Macrophage
Cytotoxicity Mediated by IgE Antibody -- Session III IgE-Dependent Activation and Release of Chemical Mediators -- Function and Structure of Immunoglobulin E (IgE) -- Functions and Development of Cell Receptors for IgE -- Modes of
Action of Antigen-Antibody Reaction and Compound 48/80 in Histamine Release -- Discussion Remark: Protein Kinases in Rat Mast Cells -- The Interdependence of Allergic and Inflammatory Processes -- Influence of Calcium Ions and
Metabolic Energy (ATP) on Histamine Release -- Molecular Events in Membrane Fusion Occurring During Mast Cell Degranulation -- Mast Cell-Derived Mediators: Structural and Functional Diversity and Regulation of Expression --
Prostaglandins and Related Substances in Acute Allergie Reactions -- Session IV Generation of Biologically Active Substances and Mediator - Target Cell Interactions -- The Anaphylatoxins: Formation, Structure, Function and Control --
Some Interrelations Among Chemotaxis, Lysosomal Enzyme Secretion and Phagocytosis by Neutrophils -- The Hageman Factor System: Mechanism of Contact Activation -- Neutrophil Generation of Permeability Enhancing Peptides from Plasma
Substrates -- Specificity and Modulation of the Eosinophil Polymorphonuclear Leukocyte Response to the Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A) -- Lymphocyte Mediators, Activated Macrophages, and Tumor Immunity --
Participants
ISBN:9781461343042
Series:eBooks
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Keywords: Medicine , Immunology , Biomedicine , Immunology
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Call number:SPRINGER-1974-9783642884153:ONLINE Show nearby items on shelf
Title:The Genetic Structure of Populations
Author(s): Albert Jacquard
Date:1974
Size:1 online resource (572 p.)
Note:10.1007/978-3-642-88415-3
Contents:The Individual -- The Population -- General Bibliography -- 1 Basic Facts and Concepts -- 1. The Foundations of Genetics -- 2. Basic Concepts and Notation. Genetic Structure of Populations and of Individuals -- 2 A Reference Model:
Absence of Evolutionary Factors -- 3. The Hardy-Weinberg Equilibrium for one Locus -- 4. The Equilibrium for Two Loci -- 5. The Inheritance of Quantitative Characters -- 6. Genetic Relationships between Relatives -- 7. Overlapping
Generations -- 3 The Causes of Evolutionary Changes in Populations -- 8. Finite Populations -- 9. Deviations from Random Mating -- 10. Selection -- 11. Mutation -- 12. Migration -- 13. The Combined Effects of Different Evolutionary
Forces -- 4 The Study of Human Population Structure -- 14. Genetic Distance. I. Basic Concepts and Methods -- 15. Genetic Distance. II. The Representation of Sets of Objects -- 16. Some Studies of Human Populations -- Conclusion --
Appendix A. Linear Difference Equations -- 1. Definitions -- 2. The Solution of Linear Difference Equations -- Appendix B. Some Definitions and Results in Matrix Algebra -- 1. Definitions -- 1.1. Types of Matrix -- 1.2. The Determinant
of a Matrix -- 1.3. Matrix Addition and Multiplication -- 2. Diagonalisation of a Square Matrix -- 2.1. The Powers of a Matrix -- 2.2. The Eigenvalues of a Matrix -- 3. The Spectral Analysis of a Matrix -- 4. Real Symmetric Matrices --
4.1. The Eigenvalues of a Real Symmetric Matrix are all Real -- 4.2. The Eigenvectors of a Real Symmetric Matrix Corresponding to Distinct Eigenvalues are Orthogonal -- 5. Stochastic Matrices -- 5.1. The Eigenvalues of Stochastic
Matrices -- 5.2. The Spectral Analysis of a Stochastic Matrix -- References
ISBN:9783642884153
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Biomathematics: 5
Keywords: Mathematics , Business , Management science , Mathematics , Mathematics, general , Business and Management, general
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Call number:SPRINGER-1974-9781461345503:ONLINE Show nearby items on shelf
Title:The Immunoglobulin a System
Author(s):
Date:1974
Size:1 online resource (555 p.)
Note:10.1007/978-1-4613-4550-3
Contents:Session A Developmental and Cellular Aspects Chairman: Lars A. Hanson -- The IgA System in Connection with Local and Systemic Immunity -- Origin, Distribution, and Differentiation of IgA-Producing Cells -- Cell Types Contributing to
the Biosynthesis of sIgA -- DISCUSSION I -- Gut-Associated Lymphoblasts and Intestinal IgA Plasma Cells -- Bronchial Lymphoid Tissue -- The Origin of Monomeric and Polymeric Forms of IgA in Man -- Cytophilic Properties of IgA to Human
Neutrophils -- DISCUSSION II -- Session B Structure, Biosynthesis, and Genetics Chairman: J. Claude Bennett -- Characteristics of SC-Ig Complexes Formed in vitro -- Association of S-IgA Subunits -- Modulation of the Assembly of
Immunoglobulin Subunits -- DISCUSSION I - E. C. Franklin, Initial Discussant -- Mechanism of Immunoglobulin Polymer Assembly -- Assembly and Secretion of Immunoglobulin A -- Special Characteristics of the IgA2 Subclass -- Genetics and
Evolution of Human Immunoglobulin A -- Physical-Chemical Characteristics of J Chains Obtained from IgM -- DISCUSSION II -- Session C Structure Chairman: Jiri Mestecky -- Isolation, Properties, and Structure of Human IgA Myeloma
Globulins -- Amino Acid Sequence Studies of Human IgA Myeloma Proteins -- Structural Studies on a Human IgA1 Myeloma Protein with a Carboxy Terminal Deletion -- The Hinge Peptide of an IgA2m(2) Myeloma Protein -- The Carbohydrate
Composition of Glycopeptides Isolated from IgA2 Immunoglobulin -- Mouse IgA Myeloma Proteins with Alpha Chain Deletions: A Comparison with Human Alpha Chains with Deletions -- DISCUSSION I -- Evidence for a Common Synthetic Origin for
Secretory and Serum IgA -- Studies on the Primary Structure of Human Secretory Component -- Production of an Fc Fragment from Human Immunoglobulin A by an IgA-Specific Bacterial Protease -- Precipitin Cross-Reactions between Human and
Animal J-Chains -- Disulfide Bridges of Human Immunoglobulins A1 and A2 -- DISCUSSION II -- Session D Function Chairman: Frederick W. Kraus -- Implications of Secretory Immune System in Viral Infections -- The Role of the Secretory
Immune System in Protection Against Agents Which Infect the Respiratory Tract -- The Role of Immunization in Controlling Antigen Uptake from the Small Intestine -- Lack of C3 Activation through Classical or Alternate Pathways by Human
Secretory IgA Anti-Blood Group A Antibody -- DISCUSSION I -- Bacterial Adherence to Mucosal Surfaces and Its Inhibition by Secretory Antibodies -- Specificity of Antibodies to Streptococcus Mutans Significance in Inhibition of
Adherence -- Secretory Antibodies in Milk of Swine Against Transmissible Gastroenteritis Virus -- Secretory IgA and Direct Killing of Shigella by Serum Components -- DISCUSSION II -- Session E Clinical Considerations Chairman: Max D.
Cooper -- Current Knowledge on Alpha Chain Disease -- The Cellular Basis of IgA Deficiency in Humans -- Alpha Chain Determinants on the Membrane of Immunoglobulin Synthesizing Cells -- Secretory and Serum IgA in Children with
Protein-Calorie Malnutrition -- Studies of Secretory Antibodies to E. Coli in Human Urine Compared to the Serum Antibody Content -- Secretory IgA: An Adolescent Coming of Age -- DISCUSSION I -- Types of Size Heterogeneity of IgA
Molecules Isolated from Myeloma and Normal Human Serum -- Distribution of IgA Subclasses in Sera and Bone Marrow Plasma Cells of 21 Normal Individuals -- Selective IgA Deficiency and Chronic Obstructive Pulmonary Disease — A Family
Study -- DISCUSSION II -- Session F The IgA Antibody Response Implications for Oral Health Chairman: Alexander R. Lawton -- The Induction and Characterization of Secretory IgA Antibodies -- Human Nasal Exocrine IgA Antibody: Formation
and Some Activities -- The IgA Antibody-Forming Cell Response in the Rabbit Submandibular Gland Following Several Different Methods of Immunization -- The Establishment of Systemic Immunity Following Antigenic Stimulation of the
Lymphoid Tissue of the Gastrointestinal Mucosa -- DISCUSSION I -- The Relationship between Serum and Salivary Antibodies and Cell Mediated Immunity in Oral Disease in Man -- Oral Manifestations of IgA Deficiency -- DISCUSSION II --
Conclusion -- Impressions, Summary, and Questions Raised by the IgA Symposium -- Program Participants
ISBN:9781461345503
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Medicine , Immunology , Biomedicine , Immunology
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Call number:SPRINGER-1968-9789401033558:ONLINE Show nearby items on shelf
Title:Population Genetics
Author(s): W. J Ewens
Date:1968
Size:1 online resource (160 p.)
Note:10.1007/978-94-010-3355-8
Contents:1. The Hardy-Weinberg Law -- 1.1. The Hardy-Weinberg law -- 1.2. Random union of gametes -- 1.3. Dioecious populations -- 1.4. Sex-linked genes and multiple alleles -- 1.5. Miscellaneous results -- 1.6. The effect of selection -- 2. Selection and Mu tation -- 2.1. Changes in gene frequency -- 2.2. The mean fitness of the population -- 2.3. The effect of mutation -- 2.4. Genetic loads -- 3. The Fundamental Theorem of Natural Selection -- 3.1. Random-mating populations -- 3.2. Two allele, non-random-ma ting populations 24 -- 3.3 Discussion -- 4. Stochastic Treatment Discrete Processes -- 4.1. Wright’s model -- 4.2. Generalizations: the effective population size -- 4.3. Bisexual populations -- 4.4. Cyclic population size -- 4.5. Geographical subdivisio n -- 4.6. General offspring distributions -- 4.7. The asymptotic conditional distribution and the transient function -- 4.8. Selection and mutation -- 5. Diffusion Approximations -- 5.1. The Fokker-Planck equation -- 5.2. The drift function
-- 5.3. The asymptotic conditional distribution -- 5.4. The backward differential equation -- 6. Applications -- 6.1. Absorption probabilities -- 6.2. Mean absorption times -- 6.3. Stationary distributions -- 6.4. The maintenance of alleles by mutat ion -- 6.5. Self-sterility alleles -- 6.6. Comparison with formulae of Fisher -- 7. Results Derived from Branching Processes -- 7.1. Survival probabilities -- 7.2. Multiple alleles -- 7.3. Fluctuating environments -- 7.4. Selectively disadvantageous mutan ts -- 8. Two-locus Behaviour -- 8.1. Introduction -- 8.2. Changes in gamete frequency -- 8.3. The effect of selection -- 8.4. What is’ interaction’? -- 9. Linkage -- 9.1. Equilibrium points and their stability behaviour -- 9.2. Increase in frequency o f rare genes -- 9.3. Initial increase in two mutant genes -- 9.4. Sudden changes in mean fitness -- 9.5. Linkage and the genetic load -- 9.6. Linkage and the survival of a new mutant -- 10. Dominance -- 10.1. Dominance of the wild type -- 10.2.
Primary genes which are initially rare -- 10.3. Dominance and the genetic load -- 11. Summary -- Author Index
ISBN:9789401033558
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Series:Springer eBooks
Keywords: Life sciences , Human genetics , Ecology , Evolutionary biology , Life Sciences , Evolutionary Biology , Human Genetics , Ecology
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