Fermilab Fermilab Core Computing Division

Library Home |  Ask a Librarian library@fnal.gov |  Book Catalog |  Library Journals |  Requests |  SPIRES |  Fermilab Documents |

Fermilab Library
SPIRES-BOOKS: FIND KEYWORD PROTEINS *END*INIT* use /tmp/qspiwww.webspi1/25789.47 QRY 131.225.70.96 . find keyword proteins ( in books using www Cover
Image
Call number:9783319451299:ONLINE Show nearby items on shelf
Title:Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
Author(s): Yogambigai Velmurugu
Date:2017
Size:1 online resource (XXI, 199 p. 112 illus., 105 illus. in color p.)
Contents:Introduction -- Methods -- Integration Host Factor (IHF)-DNA interaction -- Lesion Recognition by Xeroderma Pigmentosum C (XPC) Protein -- DNA Mismatch Repair
ISBN:9783319451299
Series:eBooks
Series:Springer eBooks
Series:Springer 2017 package
Keywords: Physics , Proteins , Spectroscopy , Microscopy , Physics , Biological and Medical Physics, Biophysics , Spectroscopy and Microscopy , Protein-Ligand Interactions
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:9783319307282:ONLINE Show nearby items on shelf
Title:Quantifying Interactions of Biomolecules with Inorganic Surfaces
Author(s): Abhijeet Patra
Date:2017
Size:1 online resource (XVIII, 102 p. 39 illus., 35 illus. in color p.)
Contents:Introduction -- Methods -- Quantifying interactions between water and surfaces -- Quantifying interactions between lipids and surfaces -- Quantifying interactions between serum proteins and gold nanoparticles -- Conclusion
ISBN:9783319307282
Series:eBooks
Series:Springer eBooks
Series:Springer 2017 package
Keywords: Physics , Nanochemistry , Amorphous substances , Complex fluids , Nanoscale science , Nanoscience , Nanostructures , Physical measurements , Measurement , Materials , Thin films , Physics , Nanoscale Science and Technology , Surfaces and Interfaces, Thin Films , Soft and Granular Matter, Complex Fluids and Microfluidics , Nanochemistry , Measurement Science and Instrumentation
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2016-9783319395340:ONLINE Show nearby items on shelf
Title:Nanoscale Imaging and Characterisation of Amyloid-β
Author(s): Claire Louisa Tinker-Mill
Date:2016
Size:1 online resource (14 p.)
Note:10.1007/978-3-319-39534-0
Contents:Introduction -- Literature Review and Theoretical Concepts -- Experimental Methodology -- Substrate Development of the Imaging of Amyloid Proteins with SPM Methods -- Scanning Probe Microscopy Methods of Imaging Amyloid Peptides
During the Aggregation Process -- Spectroscopy and Thermal SPM Methods of Studying Aβ1:42 -- The Application of Biophysical Techniques to the Study of the Inhibition of Aggregation of Aβ Using PINPs Liposomes -- Conclusion and Future
Perspectives
ISBN:9783319395340
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Molecular biology , Neurology , Amorphous substances , Complex fluids , Spectroscopy , Microscopy , Nanotechnology , Physics , Spectroscopy and Microscopy , Soft and Granular Matter, Complex Fluids and Microfluidics , Molecular Medicine , Neurology , Nanotechnology
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2014-9783642538391:ONLINE Show nearby items on shelf
Title:Membrane Transport Mechanism [electronic resource] : 3D Structure and Beyond
Author(s): Reinhard Krmer
Christine Ziegler
Date:2014
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer
Size:1 online resource
Note:This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing number of atomic structures of transporters in different conformations and the constantprogress in bioinformati cs have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access tosubstrate binding sites from either side of a cellu lar membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: thealternating access mechanism. This book brings together particularly si gnificant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFStransporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples imp ressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies hasmade it possible to create a conclusive picture, or, more precisely, a molecular movie. Although we are still far fro m a complete molecular description of the alternating access mechanism, remarkable progress has been made fromstatic snapshots towards membrane transport dynamics
Contents:Dance Lessons for Proteins: The Dynamics and Thermodynamics of a Sodium/Aspartate Symporter
Characterizing the Structure, Function and Evolution of Human Solute Carrier (SLC) Transporters Using Computational Approaches
Structures of the Prokaryotic Galactose Transporter vSGLT and Their Implications on Alternating Access Mechanism in Human SGLT1
Moving Crystallographic Snapshots: A Mechanism for Transport Regulation in BetP
Development of Refined Homology Models: Adding the Missing Information to the Medically Relevant Neurotransmitter Transporters
The Life and Times of Lac Perme
ISBN:9783642538391
Series:eBooks
Series:SpringerLink
Series:Springer Series in Biophysics, 0932-2353 : v17
Series:Physics and Astronomy (Springer-11651)
Keywords: Life sciences , Bioinformatics , Biochemistry , Cell membranes , Crystallography
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2014-9783319016986:ONLINE Show nearby items on shelf
Title:The Structure of Ionic Liquids [electronic resource]
Author(s): Ruggero Caminiti
Lorenzo Gontrani
Date:2014
Publisher:Cham : Springer International Publishing : Imprint: Springer
Size:1 online resource
Note:This volume describes the most recent findings on the structure of ILs interpreted through cutting-edge experimental and theoretical methods. Research in the field of ionic liquids (ILs) keeps a fast and steady pace. Since thesenew-generation molten salts first appeared in the chemistry and physics landscape, a large number of new compounds has been synthesized. Most of themdisplay unexpected behaviour and possess stunning properties. The coverage in thisbook ranges from the mesoscopic structure of I Ls to their interaction with proteins. The reader will learn how diffraction techniques (small and large angle X-Ray and neutron scattering, powder methods), X-Ray absorption spectroscopies(EXAFS/XANES), optical methods (IR, RAMAN), NMR and calorimetric m ethods can help the study of ILs, both as neat liquids and inmixtures with other compounds. It will enable the reader to choose the best method to suit theirexperimental needs. A detailed survey of theoretical methods, both quantum-chemical and classical, and of their predictive power will accompany the exposition of experimental ones. This book is a must read for postgraduate students,for post-docs, and for researchers who are interested in understanding the structural properties of ILs
Contents:1 X
Ray Diffraction Studies of Ionic Liquids: from Spectra to Structure and Back
2Structural Organization in Neat Ionic Liquids and in their Mixtures
3 Raman Spectroscopy in Ionic Liquids under Variable Thermodynamic and Environmental Conditions
4 CompChem and NMR Probing Ionic Liquids
5 TheoreticalDescription of Ionic Liquids
6 Structural Characterization of Ionic Liquids by X
Ray Absorption Spectroscopy
7 Physical
Chemical Properties of Ionic Liquid
containing Mixtures
ISBN:9783319016986
Series:eBooks
Series:SpringerLink
Series:Soft and Biological Matter, 2213-1736
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Chemical engineering , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2014-9783319007359:ONLINE Show nearby items on shelf
Title:Towards Autonomous Soft Matter Systems [electronic resource] : Experiments on Membranes and Active Emulsions
Author(s): Shashi Thutupalli
Date:2014
Publisher:Cham : Springer International Publishing : Imprint: Springer
Size:1 online resource
Note:This book focuses on the assembly, organization and resultant collective dynamics of soft matter systems maintained away from equilibrium byan energy flux. Living matter is the ultimate example of such systems, which arecomprised of different constit uents on very different scales (ions, nucleic acids, proteins, cells). The result of their diverse interactions, maintained using the energy from physiological processes, is a fantastically well-organizedand dynamic whole. This work describes results from minimal, biomimetic systems and primarily investigates membranes and active emulsions, as well as key aspects of both soft matter and non-equilibrium phenomena. It isshown thatthese minimal reconstitutions are already capable of a range of complex behavi our such as nonlinear electric responses, chemical communication and locomotion. These studies will bring us closer to a fundamental understanding of complexsystems by reconstituting key aspects of their form and function in simple model systems. Further, they may also serve as the first technological steps towards artificial soft functional matter
Contents:Membranes
Microfluidic membrane networks
Electrostatic interactions in membrane fusion
Phase contrast X
ray imaging of lipid membranes
Oscillating droplets: Chemical micro
oscillators
Swimming droplets: Artificial squirmers
Interacting droplets: Collective dynamics
Conclusions and Outlook
Appendices
Materials and Methods
Hydrodynamic flow fields with axial symmetry
ISBN:9783319007359
Series:eBooks
Series:SpringerLink
Series:Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2014-9781461488996:ONLINE Show nearby items on shelf
Title:Hadron Therapy Physics and Simulations [electronic resource]
Author(s): Marcos dvila Nunes
Date:2014
Publisher:New York, NY : Springer New York : Imprint: Springer
Size:1 online resource
Note:This brief provides an in-depth overview of the physics of hadron therapy, ranging from the history to the latest contributions to the subject. It covers the mechanisms of protons and carbon ions at the molecular level (DNA breaksand proteins 53BP1 a nd RPA), the physics and mathematics of accelerators (Cyclotron and Synchrotron), microdosimetry measurements (with new results so far achieved), and Monte Carlo simulations in hadron therapy using FLUKA (CERN) andMCHIT (FIAS) software. The text also incl udes information about proton therapy centers and carbon ion centers (PTCOG), as well as a comparison and discussion of both techniques in treatment planning and radiation monitoring. This briefis suitable for newcomers to medical physics as well as seaso ned specialists in radiation oncology
Contents:Brief History of Radiotherapy
Time line of Hadron Therapy
Mechanism of Hadron Therapy at molecular level
Strengthening concepts about variations in therapy by radiation
Which conditions can be treated by Hadron Therapy?
Hospitals and Research Centers for cancer treatment by Hadron
Particle therapy facilities in operation (incl. patient statistics)
Tumors: localization
Using boro
therapy to treat tumors
Which therapy must be used? Where? Conduct before and during treatment used at HIT
After Modern Radiotherapy: estimating risk of second malignancies
Particles a
ISBN:9781461488996
Series:eBooks
Series:SpringerLink
Series:SpringerBriefs in Physics, 2191-5423
Series:Physics and Astronomy (Springer-11651)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2013-9789400753136:ONLINE Show nearby items on shelf
Title:Nano-Optics for Enhancing Light-Matter Interactions on a Molecular Scale [electronic resource] : Plasmonics, Photonic Materials and Sub-Wavelength Resolution
Author(s): Baldassare Di Bartolo
John Collins
Date:2013
Publisher:Dordrecht : Springer Netherlands : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This volume presents a considerable number of interrelated contributions dealing with the new scientific ability to shape and control matter and electromagnetic fields on a sub-wavelength scale. The topics range from thefundamental ones, such as phot onic metamateriials, plasmonics and sub-wavelength resolution to the more applicative, such as detection of single molecules, tomography on a micro-chip, fluorescence spectroscopy of biological systems,coherent control of biomolecules, biosensing of singl e proteins, terahertz spectroscopy of nanoparticles, rare earth ion-doped nanoparticles, random lasing, and nanocoax array architecture. The various subjects bridge over thedisciplines of physics, biology and chemistry, making this volume of interest to p eople working in these fields. The emphasis is on the principles behind each technique and on examining the full potential of each technique. Thecontributions that appear in this volume were presented at a NATO Advanced Study Institute that was held in Er ice, Italy,3-18 July, 2011. The pedagogical aspect of the Institute is reflected in the topics presented in this volume
Note:Springer eBooks
ISBN:9789400753136
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science for Peace and Security Series B: Physics and Biophysics, 1874-6500
Series:Physics and Astronomy (Springer-11651)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2013-9783642375552:ONLINE Show nearby items on shelf
Title:Protein-Nanoparticle Interactions [electronic resource] : The Bio-Nano Interface
Author(s): Masoud Rahman
Sophie Laurent
Nancy Tawil
L'Hocine Yahia
Morteza Mahmoudi
Date:2013
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulatesystems are of signific ant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediatelycovered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a biological identity totheir surfaces (referred to as a corona), which determines the subsequent cel lular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called bio-nano interface, has been veryrarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the impor tance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed indetail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limi tations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry,nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussi on of the possibilities for enhancing the current methods and a call fornew techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts
Note:Springer eBooks
Contents:The Biological Significance of Nano interactions
Nanoparticle and Protein Corona
Protein Corona: Applications and Challenges
Analytical Methods for Corona Evaluations
ISBN:9783642375552
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Biophysics, 0932-2353 : v15
Series:Physics and Astronomy (Springer-11651)
Keywords: Life sciences , Toxicology , Biochemistry , RNA-ligand interactions , Nanotechnology
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2013-9781461451280:ONLINE Show nearby items on shelf
Title:Distance Geometry [electronic resource] : Theory, Methods, and Applications
Author(s): Antonio Mucherino
Carlile Lavor
Leo Liberti
Nelson Maculan
Date:2013
Publisher:New York, NY : Springer New York : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Distance Geometry:Theory, Methods, and Applications is the first collection of research surveys dedicated to distance geometry and its applications. The first part of the book discusses theoretical aspects of the DistanceGeometry Problem (DGP), where the relation between DGP and other related subjects are also presented. Covered topics include distance matrix theory, Euclidean distance matrix completion, multispherical structure of distance matrices,geometric algebra, algebraic distance geometry theo ry, visualization of K-dimensional structures in the plane, graph rigidity, and theory of discretizable DGP. The second part of this volume presents mathematical and computationalproperties of methods developed to the problems discussed in the first porti on, including continuous methods (based on Gaussian and hyperbolic smoothing, difference of convex functions, semidefinite programming, branch-and-bound),discrete methods (based on branch-and-prune, geometric build-up, graph rigidity), and also heuristics methods (based on simulated annealing, genetic algorithms, tabu search, variable neighborhood search). Applications comprise thethird part of the book, which is mainly devoted to the application of DGP to NMR structure calculation. This is an important a nd strongly multidisciplinary application in biology and biomedicine
Note:Springer eBooks
Contents:Preface
1. Universal Rigidity of Bar Frameworks in General Position (A. Alfakih)
2. Mixed Volume and Distance Geometry Techniques for Counting Euclidean Embeddings of Rigid Graphs (I. Emiris, E. Tsigaridas, A. Varvitsiotis)
3. (The discretizable molecular distance Geometry Problem Seems Easier on Proteins (L. Liberti, C. Lavor, A. Mucherino)
4. Spheres Unions and Intersections and Some of Their Applications in Molecular Modeling (M. Petitjean)
5. Is the Distance Geometry Problem in NP? (N. Beeker, S. Gaubert, C. Glusa, L. Liberti)
6. Solving Spatial Constraints with Generaliz
ISBN:9781461451280
Series:e-books
Series:SpringerLink (Online service)
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Visualization , Geometry
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2012-9789400755802:ONLINE Show nearby items on shelf
Title:Uniting Electron Crystallography and Powder Diffraction [electronic resource]
Author(s): Ute Kolb
Kenneth Shankland
Louisa Meshi
Anatoly Avilov
William I.F David
Date:2012
Publisher:Dordrecht : Springer Netherlands : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The polycrystalline and nanocrystalline states play an increasingly important role in exploiting the properties of materials, encompassing applications as diverse as pharmaceuticals, catalysts, solar cells and energy storage. Aknowledge of the three- dimensional atomic and molecular structure of materials is essential for understanding and controlling their properties, yet traditional single-crystal X-ray diffraction methods lose their power when onlypolycrystalline and nanocrystalline samples are ava ilable. It is here that powder diffraction and single-crystal electron diffraction techniques take over, substantially extending the range of applicability of the crystallographicprinciples of structure determination. This volume, a collection of teaching contributions presented at the Crystallographic Course in Erice in 2011, clearly describes the fundamentals and the state-of-the-art of powder diffractionand electron diffraction methods in materials characterisation, encompassing a diverse range of disc iplines and materials stretching from archeometry to zeolites. As such, it is a comprehensive and valuable resource for thosewishing to gain an understanding of the broad applicability of these two rapidly developing fields
Note:Springer eBooks
Contents:Preface
Part 1 Powder Diffraction
Powder Diffraction: By Decades
Rietveld Refinement
Structure Solution
an Overview
Inorganic Materials
Organic Compounds
Laboratory X
ray Diffraction
Synchrotron X
Ray Powder Diffraction
Ultra Fast Powder Diffraction
Taking it to Extremes Powder Diffraction at Elevated Pressures
Structure Solution by Charge Flipping
Structure Solution: Global Optimisation Methods
Proteins and Powders: Technical Developments
Proteins and Powders: An Overview
Parametric Powder Diffraction
Powder Diffraction + Computational M
ISBN:9789400755802
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science for Peace and Security Series B: Physics and Biophysics, 1874-6500
Series:Physics and Astronomy (Springer-11651)
Keywords: Crystallography , Materials , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2012-9783642239885:ONLINE Show nearby items on shelf
Title:Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane [electronic resource]
Author(s): Ksenia Guseva
Date:2012
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on thefunction of membrane protei ns, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twinarginine translocation (Tat) system. Using methods f rom equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the firstpart a general aggregation dynamics model is formulated, and used to show th at fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into asimplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitiv e channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model thatincorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive descriptio n of this self-organizing process
Note:Springer eBooks
Contents:Introduction
The Role of Fragmentation on the Formation of Homomeric Protein Complexes
Collective Response of Self
organised Clusters of Mechanosensitive Channels
Assembly and Fragmentation of Tat Pores
Conclusion
ISBN:9783642239885
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Theses
Series:Physics and Astronomy (Springer-11651)
Keywords: Polymers , Cell membranes
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2012-9783642222306:ONLINE Show nearby items on shelf
Title:Protein Folding and Misfolding [electronic resource] : Shining Light by Infrared Spectroscopy
Author(s): Heinz Fabian
Dieter Naumann
Date:2012
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Infrared spectroscopy is a new and innovative technology to study protein folding/misfolding events in the broad arsenal of techniques conventionally used in this field. The progress in understanding protein folding and misfoldingis primarily due to the development of biophysical methods which permit to probe conformational changes with high kinetic and structural resolution. The most commonly used approaches rely on rapid mixing methods to initiate the foldingevent via a sudden change in solvent con ditions. Traditionally, techniques such as fluorescence, circular dichroism or visible absorption are applied to probe the process. In contrast to these techniques, infrared spectroscopy cameinto play only very recently, and the progress made in this fiel d up to date which now permits to probe folding events over the time scale from picoseconds to minutes has not yet been discussed in a book. The aim of this book is toprovide an overview of the developments as seen by some of the main contributors to the field. The chapters are not intended to give exhaustive reviews of the literature but, instead to illustrate examples demonstrating the sort ofinformation, which infrared techniques can provide and how this information can be extracted from the experiment al data. By discussing the strengths and limitations of the infrared approaches for the investigation of folding andmisfolding mechanisms this book helps the reader to evaluate whether a particular system is appropriate for studies by infrared spectroscop y and which specific advantages the techniques offer to solve specific problems
Note:Springer eBooks
Contents:Reconstruction of the Amide I contour in the IR spectra of proteins: From structure to spectrum R.Mendelsohn (USA)
Millisecond
to
minute time
resolved protein folding/misfolding events monitored by FTIR spectroscopy H. Fabian & D. Naumann (Germany)
Sub
millisecond events in proteins probed by continuous
flow FTIR experiments S. Takahashi (Japan)
Protein folding/misfolding at high pressure probed by FTIR spectroscopy R. Winter (Germany)
Site
specific relaxation kinetics of peptides using temperature
jump IR spectroscopy and isotopic labelling A. Barth (Sweden), K.Hauser (Germany)
ISBN:9783642222306
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Biochemistry , Biomaterials
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2011-9789400705852:ONLINE Show nearby items on shelf
Title:Soft Matter [electronic resource] : The stuff that dreams are made of
Author(s): Roberto Piazza
Date:2011
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Soft matter may, as Roberto Piazza puts it, be the stuff of dreams, but it is also the stuff of life. That is what makes this book so engaging because it shows the ingenuity that both nature and humankind have invested inthe bendy, stretchy, fragile , tough and adaptable substances we find all around us. There is plenty of hard science in this soft matter, and Piazza offers an urbane and eloquent tour through it. Philip Ball, multi-award winningscience writer. This book takes you for a leisurely walk through the middle earth that scientists call soft matter -- much smaller than what we observe with the naked eye, but not as remote as the esoteric realm of molecules,atoms and fundamental particles. From toys to trainers, our civilization would be very different if we did not have plastic. From milk to paint, what would we do without colloids? We ourselves fall into the category of soft matter,made as we are of a molecular origami of proteins, DNA and other biological compounds. This fascinating explor ation reveals what these materials have in common and which aspects of their behavior make them useful in our everydaylife. Understanding more about their physical properties will make you marvel at the soft things that surround us. With a Foreword by Pro fessor Henk Lekkerkerker, Utrecht University, the Netherlands Roberto Piazza trained as aphysicist at the school of Vittorio Degiorgio, and is now a professor of Condensed Matter Physics at the Politecnico di Milano, Italy, Associate Editor of the Europea n Physical Journal E and coordinator of the European Space Agency'sTopical Team for Applications of colloids in microgravity of the European Space Agency. He has made important contributions to research on nanoparticle suspensions, polymer and surfactant solutions and biological macromolecules.He is not only a gifted physicists, but equally well versed in history and literature
Note:Springer eBooks
Contents:Foreword
Preface to the English edition
1 Overture: a special day
2 A life in suspense
3 Freedom in chains
4 Double
faced Janus Molecules
5 Nanoarchitecture
6 Dreamtime
Weird words: soft matter from A to Z
Index of common things (or almost so)
ISBN:9789400705852
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Polymers , Mathematics , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2011-9781461407034:ONLINE Show nearby items on shelf
Title:Advances on Fractional Inequalities [electronic resource]
Author(s): George A Anastassiou
Date:2011
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Advances on Fractional Inequalities use primarily the Caputo fractional derivative, as the most important in applications, and presents the first fractional differentiation inequalities of Opial type which involves thebalanced fractional derivatives. The book continues with right and mixed fractional differentiation Ostrowski inequalities in the univariate and multivariate cases. Next the right and left, as well as mixed, Landau fractionaldifferentiation inequalities in the univariate and multivariat e cases are illustrated. Throughout the book many applications are given. Fractional differentiation inequalities are by themselves an important and great mathematical topicfor research. Furthermore they have many applications, the most important ones are in establishing uniqueness of solution in fractional differential equations and systems and in fractional partial differential equations. Also theyprovide upper bounds to the solutions of the above equations. Fractional Calculus has emerged as very usefu l over the last forty years due to its many applications in almost all applied sciences. This is currently seen in applicationsin acoustic wave propagation in inhomogeneous porous material, diffusive transport, fluid flow, dynamical processes in self-simi lar structures, dynamics of earthquakes, optics, geology, viscoelastic materials, bio-sciences,bioengineering, medicine, economics, probability and statistics, astrophysics, chemical engineering, physics, splines, tomography, fluid mechanics, electromagne tic waves, nonlinear control, signal processing, control of powerelectronic, converters, chaotic dynamics, polymer science, proteins, polymer physics, electrochemistry, statistical physics, rheology, thermodynamics, neural networks, etc. Almost all fields of research in science and engineering usefractional calculus in order to describe results. This book is a part of Fractional Calculus, therefore it is useful for researchers and graduate student
Note:Springer eBooks
ISBN:9781461407034
Series:e-books
Series:SpringerLink (Online service)
Series:SpringerBriefs in Mathematics, 2191-8198
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Differential Equations , Mathematical optimization
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2011-9780387928081:ONLINE Show nearby items on shelf
Title:Biophysics of DNA-Protein Interactions [electronic resource] : From Single Molecules to Biological Systems
Author(s): Mark C Williams
L. James Maher
Date:2011
Publisher:New York, NY : Springer New York : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteinsinteract with DNA. For exam ple, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as forcespectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by whichproteins engage DNA sequences and/or alter DNA structure. These simple but imp ortant model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replicationforks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chro matin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches toDNA-protein interactions across multiple levels of biological complexity
Note:Springer eBooks
Contents:Introduction
Nonspecific DNA Binding: Searching DNA and Altering DNA Properties
DNA Search Theory
DNA Search, Hopping vs. Sliding
SSB DNA Search
HN
S Proteins or DNA Sliding Search
Processivity Clamp
DNA Bending Proteins
Kinetics of DNA Binding and Bending by Proteins
Modes of DNA Interaction by Architectural Proteins
Complex Protein
DNA Interactions
DNA Looping by Repressor Proteins
NF
kappaB Transcription Factor Crystallography
Replication Complex
DNA Recombination Complexes
DNA Binding by Alkyltransferase Repair Proteins
DNA Polymerase Crystal
ISBN:9780387928081
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biochemistry , Cytology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2010-9783642030222:ONLINE Show nearby items on shelf
Title:Methods in Modern Biophysics [electronic resource]
Author(s): Bengt Nlting
Date:2010
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Incorporating recent dramatic advances, this textbook presents a fresh and timely introduction to modern biophysical methods. An array of new, faster and higher-power biophysical methods now enables scientists to examine themysteries of life at a mol ecular level. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobilityspectrometry, mass spectrometry, proteomics, and protein folding and structure. Incorporating much information previously unavailable in tutorial form, Nlting employs worked examples and about 270 illustrations to fully detail thetechniques and their underlying mechanisms. Methods in Modern Biophysics i s written for advanced undergraduate and graduate students, postdocs, researchers, lecturers, and professors in biophysics, biochemistry and related fields.Special features in the 3rd edition: Introduces rapid partial protein ladder sequencing - an import ant method for fast and highly sensitive identification of proteins, describes the determination of interaction surfaces in proteincomplexes by mass spectrometric mapping of binding of chemical linkers - a method to support the high-resolution structural analysis of large macromolecular assemblies
Note:Springer eBooks
Contents:The three
dimensional structure of proteins
Liquid chromatography of biomolecules
Mass spectrometry
X
ray structural analysis
Protein infrared spectroscopy
Electron microscopy
Scanning probe microscopy
Biophysical nanotechnology
Proteomics: high throughput protein functional analysis
Ion mobility spectrometry
Value analysis
Evolutionary computer programming
Rapid partial protein ladder sequencing
Surface labeling analysis of protein interactions
Conclusions
References
ISBN:9783642030222
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Biotechnology , Chemistry, Physical organic , Medicine , Biochemistry , Bioinformatics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2010-9781441910448:ONLINE Show nearby items on shelf
Title:The Physics of Proteins [electronic resource] An Introduction to Biological Physics and Molecular Biophysics
Author(s): Hans Frauenfelder
Shirley S Chan
Winnie S Chan
Date:2010
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Physics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactionsbetween physics and biolo gy form a two-way street with physics providing new tools and concepts for understanding life, while biological systems can yield new insights into the physics of complex systems. To address the challenges ofthis interdisciplinary area, The Physics of Pro teins: An Introduction to Biological Physics and Molecular Biophysics is divided into three interconnected sections. In Parts I and II, early chapters introduce the terminology anddescribe the main biological systems that physicists will encounter. Simila rities between biomolecules, glasses, and solids are stressed with an emphasis on the fundamental concepts of living systems. The central section (Parts III andIV) delves into the dynamics of complex systems. A main theme is the realization that biologica l systems, in particular proteins, do not exist in unique conformations but can assume a very large number of slightly different structures.This complexity is captured in the concept of a free energy landscape and leads to the conclusion that fluctuations are crucial for the functioning of biological systems. The final chapter of this section challenges the reader to applythese concepts to a problem that appears in the current literature. An extensive series of appendices (Part V) provide descriptions of the key physical tools and analytical methods that have proven powerful in the study of the physicsof proteins. The appendices are designed to be consulted throughout the section on protein dynamics without breaking the deductive flow of the logic in the central section of the book
Note:Springer eBooks
Contents:Part I: Biomolecules
The Hierarchy of Living Things
Information and Function
Biomolecules, Spin Glasses, Glasses, and Solids
Proteins
Nucleic Acids
The Genetic Code
Lipids and Membranes
Part II: Spatial Structure of Proteins: Measurementand Consequence
Scattering of Photons for Imaging: Diffraction and Microscopy
X
Ray Diffraction
Pulsed Nuclear Magnetic Resonance and Molecular Structure Determination in Solution
The Secondary Structure
Tertiary Structure of Proteins
Myoglobin and Hemoglobin
Part III: The Entergylandscape and Dynamics of Proteins
ISBN:9781441910448
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biochemistry , Proteomics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9789048123391:ONLINE Show nearby items on shelf
Title:From Molecules to Medicines [electronic resource] : Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism
Author(s): Joel L Sussman
Paola Spadon
Date:2009
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The synergism played by crystallography and drug discovery is the central focus of this volume which comprises papers presented at the 40th Erice Course held from 28 May to 8 June 2008. A key theme throughout the book is thedependence of modern struc tural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future
Note:Springer eBooks
Contents:Preface. List of Contributors. Surface Proteins of Gram
Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates
The Rapid Crystallization Strategy for Structure
Based Inhibitor Design
Fragment
Based Drug Discovery in Academia: Experiences from a Tuberculosis Programme
Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia
Integrating Crystallography Into Early Metabolism Studies
The Foundations of Protein
Ligand Interaction
Structure
Based Design of TRNA
Guanine Transglycosylase Inhibitors
ISBN:9789048123391
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science for Peace and Security Series A: Chemistry and Biology, 1874-6489
Series:Physics and Astronomy (Springer-11651)
Keywords: Computer simulation , Biochemistry , RNA-ligand interactions , Bioinformatics , Crystallography
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9781607613145:ONLINE Show nearby items on shelf
Title:Biomembrane Frontiers [electronic resource] : Nanostructures, Models, and the Design of Life
Author(s): Roland Faller
Marjorie L Longo
Subhash H Risbud
Thomas Jue
Date:2009
Edition:1st
Publisher:Totowa, NJ : Humana Press
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students orresearchers can learn fundament al concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applications. Withthe addition of problem sets, guides to further stu dy, and references, the interested reader can continue to explore independently the ideas presented. Volume II: Biomembrane Frontiers: Nanostructures, Models, and the Design of LifeEditors: Roland Faller, PhD, Thomas Jue, PhD, Marjorie L. Longo, PhD, and Subhash H. Risbud, PhD In Biomembrane Frontiers: Nanostructures, Models, and the Design of Life, prominent researchers have established a foundation for thestudy of biophysics related to the following topics: Perspectives: Complexes in Liquids, 19002008 M olecular Theory Applied to Lipid Bilayers and LipidProtein Interactions Membrane Elasticity and Mediated Interactions in ContinuumTheory: A Differential Geometric Approach Structure and Dynamics of Lipid Monolayers: Theory and Applications Multiscale Mode ling of Supported Lipid Bilayers Collective Dynamics in Lipid Membranes: From Pore Formation to Flip-FlopsSpatiotemporal Organization of Spin-Coated Supported Model Membranes Nanopore Analysis of Nucleic Acids: Single-Molecule Studies of Molecular Dynamic s, Structure, and Base Sequence Complex Applications of Simple FRAP on MembranesPunching Holes in Membranes: How Oligomeric Pore-Forming Proteins and Lipids Cooperate to Form Aqueous Channels in Membranes Morphogens, Membranes and Mechanotransduction in A rticular Cartilage Lifecycle of a Lipoprotein from aBiophysical Perspective Targeting Apolipoproteins in Magnetic Resonance Imaging About the Editors The editors are internationally recognized bio
Note:Springer eBooks
Contents:Molecular Theory Applied to Lipid Bilayers and LipidProtein Interactions
Membrane Elasticity and Mediated Interactions in Continuum Theory: A Differential Geometric Approach
Structure and Dynamics of Lipid Monolayers: Theory and Applications
Multiscale Modeling of Supported Lipid Bilayers
Collective Dynamics in Lipid Membranes: From Pore Formation to Flip
Flops
Spatiotemporal Organization of Spin
Coated Supported Model Membranes
Nanopore Analysis of Nucleic Acids: Single
Molecule Studies of Molecular Dynamics, Structure, and Base Sequence
Complex Applications of Simple
ISBN:9781607613145
Series:e-books
Series:SpringerLink (Online service)
Series:Handbook of Modern Biophysics
Series:Physics and Astronomy (Springer-11651)
Keywords: Biochemistry , Cytology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9781597453974:ONLINE Show nearby items on shelf
Title:Fundamental Concepts in Biophysics [electronic resource] : Volume 1
Author(s): Thomas Jue
Date:2009
Publisher:Totowa, NJ : Humana Press
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students orresearchers can learn fundament al concepts and the application of new techniques in addressing biomedical challenges. Chapters explicate the conceptual framework of the physics formalism and illustrate the biomedical applications. Withthe addition of problem sets, guides to further stu dy, and references, the interested reader can continue to explore independently the ideas presented. Volume I: Fundamental Concepts in Biophysics Editor Thomas Jue, PhD In FundamentalConcepts in Biophysics, prominent professors have established a foundati on for the study of biophysics related to the following topics: Mathematical Methods in Biophysics Quantum Mechanics Basic to Biophysical Methods ComputationalModeling of ReceptorLigand Binding and Cellular Signaling Processes Fluorescence Spectroscopy El ectrophysiological Measurements of Membrane Proteins Single-Particle Tracking NMR Measurement of Biomolecule Diffusion About the EditorThomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California Davis . He is an internationally recognized expert in developing and applying magnetic resonance techniques to studyanimal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrar ed spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology.Over the past several years, he has led the way as a Chair of the Biophysics Graduate Group Program to establish attractive but scholarly approaches to educate graduat e students with a balance of physical-science/mathematics formalismand biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and
Note:Springer eBooks
Contents:Mathematical Methods in Biophysics
Quantum Mechanics Basic to Biophysical Methods
Computational Modeling of Receptor
Ligand Binding and Cellular Signaling Processes
Fluorescence Spectroscopy
Electrophysiological Measurements of Membrane Proteins
Single Particle Tracking
NMR Measurement of Biomolecule Diffusion
ISBN:9781597453974
Series:e-books
Series:SpringerLink (Online service)
Series:Handbook of Modern Biophysics
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9781441906700:ONLINE Show nearby items on shelf
Title:Mathematics of DNA Structure, Function and Interactions [electronic resource]
Author(s): Craig John Benham
Stephen Harvey
Wilma K Olson
De Witt Sumners
David Swigon
Date:2009
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Propelled by the success of the sequencing of the human and many related genomes, molecular and cellular biology has delivered significant scientific breakthroughs. Mathematics (broadly defined) continues to play a major role inthis effort, helping t o discover the secrets of life by working collaboratively with bench biologists, chemists and physicists. Because of its outstanding record of interdisciplinary research and training, the IMA was an ideal venuefor the 2007-2008 IMA thematic year on Mathem atics of Molecular and Cellular Biology. The kickoff event for this thematic year was a tutorial on Mathematics of Nucleic Acids, followed by the workshop Mathematics of Molecular andCellular Biology, held September 15--21 at the IMA. This volume is dedic ated to the memory of Nicholas R. Cozzarelli, a dynamic leader who fostered research and training at the interface between mathematics and molecular biology. Itcontains a personal remembrance of Nick Cozzarelli, plus 15 papers contributed by workshop spea kers. The papers give and overview of state-of-the-art mathematical approaches to the understanding of DNA structure and function, and theinteraction of DNA with proteins that mediate vital life processes
Note:Springer eBooks
Contents:Foreword
Preface
Nick Cozzarelli: A personal remembrance
Mathematical methods in DNA topology: Applications to chromosome organization and site
specific recombination
Conformational statistics of DNA and diffusion equations on the Euclidean group
Perspectives on DNA looping
Differences between positively and negatively supercoiled DNA that topoisomerases may distinguish
Calibration of tethered particle motion experiments
Difference topology: Analysis of high
order DNA
protein assemblies
Useful intrusions of DNA topology into experiments on protein
DNA geometry
Top
ISBN:9781441906700
Series:e-books
Series:SpringerLink (Online service)
Series:The IMA Volumes in Mathematics and its Applications, 0940-6573 : v150
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Biological models , Biology Mathematics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9780387981734:ONLINE Show nearby items on shelf
Title:Cellular Signaling in Health and Disease [electronic resource]
Author(s): Martin Beckerman
Date:2009
Publisher:New York, NY : Springer US
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:In todays world, three great classes of non-infectious diseases the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders have risen to the fore. Thesediseases, all associated with incre asing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasisand health of the body become dysregulated, they genera te equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling inHealth and Disease summarizes our current understanding of these regulatory netwo rks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished bypresenting models that explain in mechanistic, molecular detail how a particular part of the cellular signalin g web operates properly in health and improperly in disease. The stability of the health- and disease-associated states isdynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the pa st few years an ongoing series of important discoveries have been made that advance our understandingof how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor i n all of these disease classes, the appearance of reactive oxygen species as amessenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics incl uding the emergence of small non-coding RNA with importantregulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details i
Note:Springer eBooks
Contents:Metabolic Syndromes
Energy Balance
Insulin Signaling and Type 2 Diabetes
Metabolic Program Execution and Switching
Cholesterol
Atherosclerosis
Chronic Inflammation
Redox Signaling
Cancer
The Cell Cycle
Cell Cycle Checkpoints and DNA Damage Repair
Apoptosis and Senescence
Epigenetics
Tumor Growth
Tumor Metabolism
Metastasis
Neurodegeneration
Protein Folding, Misfolding, and Aggregation
Alzheimers Disease
Chaperones, Endoplasmic Reticulum Stress, and the Unfolded Protein Response
Parkinsons Disease
Huntingtons Disease and Am
ISBN:9780387981734
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biochemistry , Cytology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2009-9780387764979:ONLINE Show nearby items on shelf
Title:Handbook of Single-Molecule Biophysics [electronic resource]
Author(s): Peter Hinterdorfer
Antoine Oijen
Date:2009
Publisher:New York, NY : Springer US
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level ofsensitivity has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transientintermediates identified, and catalytic mechanisms elucidate d. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook ofSingle-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes: Experimental techniques to monitor and manipulateindividual biomolecules The use of single-molecule techniques in super-resolution and functional imaging Single- molecule studies of physical properties of biomolecules Single-molecule enzymology and biochemistry Single molecules in themembrane Single-molecule techniques in living cells Integration of single-molecule biophysics and nanoscience
Note:Springer eBooks
Contents:Single
Molecule Fluorescent Particle Tracking
Single
Molecule Analysis of Biomembranes
Single
Molecule Imaging in Live Cells
Fluorescence Imaging at Sub
Diffraction
Limit Resolution with Stochastic Optical Reconstruction Microscopy
Single
Molecule FRET: Methods and Biological Applications
Single
Molecule Enzymology
Single
Molecule Studies of Rotary Molecular Motors
Fluorescence Correlation Spectroscopy in Living Cells
Precise Measurements of Diffusion in Solution by Fluorescence Correlations Spectroscopy
Single
Molecule Studies of Nucleic Acid Interactions Using Nano
ISBN:9780387764979
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biomedical engineering , Nanotechnology
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2008-9783540767824:ONLINE Show nearby items on shelf
Title:Biophotonics [electronic resource]
Author(s): Lorenzo Pavesi
Philippe M Fauchet
Date:2008
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:More profound understanding of the nature of light and light-matter interactions in biology has enabled many applications in the biology and medical fields. So a new discipline is born, namely biophotonics. The aim of this book isto review the curren t state-of-the-art of the field by means of authoritative chapters written by the world leaders of the respective fields. Biosensors, biochips, optical tomography, optical microsurgery, photodynamics therapy,bioactivation of gene, photobiology of skin, an d nanobiophotonics are each introduced and recent advances presented. This book will be useful not only to physicians, biologists, physicists, chemists, materials scientists, and engineersbut also to graduate students who are interested in these rapidly d eveloping fields
Note:Springer eBooks
Contents:1. Light conversion in photosynthetic organisms
2. Exploiting photosynthesis for biofuel production
3. In between photosynthesis and photoinhibition: The fundamental role of carotenoids and carotenoid
binding proteins in photoprotection
4. Nonlinear microscopy
5. Applications of optical resonance to biological sensing and imaging: Spectral self
interference microscopy
6. Applications of optical resonance to biological sensing and imaging: Resonant cavity biosensors
7. Biodetection using silicon photonic crystal microcavities
8. Optical coherence tomography with application
ISBN:9783540767824
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Ophthalmology , Surgery , Physical optics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2008-9783540739241:ONLINE Show nearby items on shelf
Title:Single Molecules and Nanotechnology [electronic resource]
Author(s): R Rigler
H Vogel
Date:2008
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book focuses on recent advances in the rapidly evolving field of single molecule research. These advances are of importance for the investigation of biopolymers and cellular biochemical reactions, and are essential to thedevelopment of quantitat ive biology. Written by leading experts in the field, the articles cover a broad range of topics, including: quantum photonics of organic dyes and inorganic nanoparticles their use in detecting properties ofsingle molecules the monitoring of single molecu le (enzymatic) reactions single protein (un)folding in nanometer-sized confined volumes the dynamics of molecular interactions in biological cells The book is written for advancedstudents and scientists who wish to survey the concepts, techniques and resu lts of single molecule research and assess them for their own scientific activities
Note:Springer eBooks
Contents:1. Nanophotonics and Single Molecules
2. Single Biomolecules at Cryogenic Temperatures: From Structure to Dynamics
3. Quantum Optics: Colloidal Fluorescent Semiconductor Nanocrystals (Quantum Dots) in Single
Molecule Detection and Imaging
4. Scanning Fluorescence Correlation Spectroscopy
5. Single
Molecule Imaging of Cellular Signaling
6. Mobility and Signaling of Single Receptor Proteins
7. Single Enzyme Kinetics: A Study of the Yeast Enzyme Candida Antarctica Lipase B
8. Protein Folding and Dynamics from Optical Single Molecule Spectroscopy
9. Single Molecules and Nan
ISBN:9783540739241
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Biophysics, 0932-2353 : v12
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Biochemistry , Nanotechnology
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2008-9781402082689:ONLINE Show nearby items on shelf
Title:Integrated Molecular and Cellular Biophysics [electronic resource]
Author(s): Valerica Raicu
Aurel Popescu
Date:2008
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book integrates concepts and methods from physics, biology, biochemistry and physical chemistry into a standalone, unitary text of biophysics that aims to provide a quantitative description of structures and processesoccurring in living matter. The book introduces graduate physics students and physicists interested in biophysics research to 'classical' as well as emerging areas of biophysics. The advanced undergraduate physics students and the lifescientists are also invited to join in, by build ing on their knowledge of basic physics. Essential notions of biochemistry and biology are introduced, as necessary, throughout the book, while the reader's familiarity with basicknowledge of physics is assumed. Topics covered include interactions between biological molecules, physical chemistry of phospholipids association into bilayer membranes, DNA and protein structure and folding, passive and activeelectrical properties of the cell membrane, classical as well as fractal aspects of reaction kinetics a nd diffusion in biological systems, structural and functional aspects of molecular machines (including channels, ion pumps, andlight-harvesting antenna), as well as fundamental aspects of proteins association in solutions and in living cells
Note:Springer eBooks
ISBN:9781402082689
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Life sciences , Physiology Mathematics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9783764375553:ONLINE Show nearby items on shelf
Title:Symmetry [electronic resource] : Cultural-historical and ontological aspects of science-arts relations The natural and man-made world in an interdisciplinary approach
Author(s): Gyrgy Darvas
Date:2007
Publisher:Basel : Birkhuser Basel
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:All of us have a certain conception of what symmetry means, at least as far as its main forms are concerned (like mirror-reflection or rotation, but only rarely translation). What are the common features of these transformations?How can one generalis e them to explain similar phenomena that appear in different arts and sciences? What other forms of symmetry can we include in the scope of our study by the application of these generalised rules? How can a commonphenomenon lend possible solutions from on e discipline to another? Did you know that symmetry is a universal concept that has appeared in all cultures since prehistoric times, accompanying us through the history of mankind? Whatimportant role have asymmetries like the one-handedness of the neutri no played in the formation of matter, from the assumed Big Bang through to the asymmetries of the human brain? This book tries to explain these and a number ofrelated questions. This is the first comprehensive book on the topic since the publication of H. Weyls popular book on symmetry more than fifty years ago. It is relevant to almost all fields of science where symmetry appears as aphenomenon or is applied as a method, and where the concept is present in contemporary sciences, humanities and arts. Symm etry used to be a fundamental phenomenon in crystallography, where its basic concept was elaborated, inmorphological biology, and of course in mathematics, which provided its exact description. In the last half century symmetry (and symmetry breaking) has become a leading principle in physics, in all sciences that deal with thestructure of matter, as well as in the biochemistry of proteins, the study of the genetic code, brain research (where functional asymmetries have been revealed), psychology, and in developing architectural structures and in businessdecision-making, to name but a few examples. This book seeks to find common regularities among these apparently disparate phenomena. It covers most
Note:Springer eBooks
Contents:Preface
Symmetry, Invariance, Harmony
Ancient arts
Geometry
Fibonacci
Crystallography
Molecules
Music
Human body
Perspectives
Theoretical Physics
Astronomy
Nature
Architecture
Bibliography
Name Index
Subject Index
ISBN:9783764375553
Series:e-books
Series:SpringerLink (Online service)
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Architecture , Arts
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9783540711278:ONLINE Show nearby items on shelf
Title:NASSAU 2006 [electronic resource] : Proceedings of the 4th Nassau Mssbauer Symposium held in Garden City, New York, USA, 1314 January 2006
Author(s): E. E Alp
C. I Wynter
Date:2007
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Progress in various areas of applications of Mssbauer Effect is reported in this volume. Among the recent developments, applications of synchrotron radiation in geophysics and biophysics through the measurement of phonon densityof states of proteins and enzymes, and laboratory based high- pressure experiments in elucidating the electronic nature of correlated electron systems in condensed matter physics are some examples. Furthermore, almost after fivedecades of its discovery, with two Mssbauer spect rometers working on the surface of the Mars provided the first glimpse of the nature of iron containing minerals. With additional contributions from applications to nano-science andstudies of amorphous systems will make this volume of special interest to materials scientists, chemists, mineral and condensed matter physicists, and inorganic biochemists alike. The conference and its proceedings are dedicated to oneof the pioneers of Mssbauer Spectroscopy, late Dr. Stanley Ruby, whose original ideas, insight and enthusiasm helped create new research fields
Note:Springer eBooks
Contents:4th Nassau Mssbauer symposium analysis and summary
Scientific legacy of Stanley Ruby
Mssbauer spectroscopy methodology at the cutting
edge of high
pressure research
Vibrational dynamics of Fe in amorphous Fe
Sc and Fe
Al alloy thin films
Nuclear Resonance Vibrational Spectroscopy (NRVS) of Fe
S model compounds, Fe
S proteins, and nitrogenase
On Spin Hamiltonian fits to Mssbauer spectra of high
spin Fe(II) porphyrinate systems
Mssbauer effect of 151Eu in europium salen complex nanoparticles
Velocity scales for Mars Mssbauer data
Nanowires of iron oxides embedde
ISBN:9783540711278
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9783540498582:ONLINE Show nearby items on shelf
Title:Topology in Molecular Biology [electronic resource]
Author(s): Michail Ilych Monastyrsky
Date:2007
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA computational methods (Monte Carlo) allowing thesimulation of large-sca le properties of DNA the tangle model of DNA recombination and other applications of Knot theory dynamics of supercoiled DNA and biocatalitic properties of DNA the structure of proteins and other very recentproblems in molecular biology. The text also pro vides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new resultspresented here are documented for the first time in monographic form
Note:Springer eBooks
Contents:1. Introduction
2. Topology in Biology: From DNA Mechanics to Enzymology
3. Monte Carlo Simulation of DNA Topological Properties
4. Dynamics of DNA Supercoiling
5. From Tangle Fractions to DNA
6. Linear Behavior of the Writhe Versus the Number of Crossings in Rational Knots and Links
7. Combinatories and Topology of the
Sandwich and
Barrel Proteins
8. The Structure of Collagen. 9. Euler Charactristic, Dehn
Sommerville Characteristics, and their Applications
10. Hopf Fibration and its Applications
11. Multivalued Functionals, One
forms and Deformed de Rham Compl
ISBN:9783540498582
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Bioinformatics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9783540495222:ONLINE Show nearby items on shelf
Title:Controlled Nanoscale Motion [electronic resource] : Nobel Symposium 131
Author(s): Heiner Linke
Alf Mnsson
Date:2007
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:When the size of a machine approaches the nanometer scale, thermal fluctuations become large compared to the energies that drive the motor. The control of motion at the nanoscale therefore requires physical understanding andtechnical approaches that are fundamentally different from those that are successful at the macroscale. This volume provides an introduction to the state-of-the-art of controlled nanoscale motion in biological and artificial systems.Topics include the control and function of prote in motors, the physics of non-equilibrium Brownian motion, and the physics and fabrication of synthetic molecular motors. The chapters in this book are based on selected contributions onthe 2005 Nobel Symposium to Controlled Nanoscale Motion and are writt en by leading experts in their fields
Note:Springer eBooks
Contents:Navigation on a Micron Scale
Myosin Motors: The Chemical Restraints Imposed by ATP
How Linear Motor Proteins Work
Axonal Transport: Imaging and Modeling of a Neuronal Process
Intracellular Transport and Kinesin Superfamily Proteins: Structure, Function and Dynamics
Studies of DNA
Protein Interactions at the Single Molecule Level With Magnetic Tweezers
Membrane Nanotubes
Macromolecular Motion at the Nanoscale of Enzymes Working on Polysaccharides
Brownian Motion After Einstein: Some New Applications and New Experiments
Nonequilibrium Fluctuations of a Single Biomolecu
ISBN:9783540495222
Series:e-books
Series:SpringerLink (Online service)
Series:Lecture Notes in Physics, 0075-8450 : v711
Series:Physics and Astronomy (Springer-11651)
Keywords: Soft condensed matter , Biomedical engineering , Biomaterials , Nanotechnology
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9781402064661:ONLINE Show nearby items on shelf
Title:Supramolecular Structure and Function 9 [electronic resource]
Author(s): Greta Pifat-Mrzljak
Date:2007
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The book is based on International Summer Schools on Biophysics held in Croatia which, contrary to other workshops centered mainly on one topic or technique, has very broad scope providing advanced training in areas related tobiophysics. This volume is presenting papers in the field of biophysics for studying biological phenomena by using physical methods (NMR, EPR, FTIR, Mass Spectrometry, etc.) and/or concepts (predictions of protein-protein interactions,virtual ligand screening etc.). The interrel ationship of supramolecular structures and there functions is enlightened by applications of principals of these physical methods in the biophysical and molecular biology context
Note:Springer eBooks
Contents:Predictions of Protein
Protein Interactions at the Atomic Scale
An Infrared Study of Fibril Formation in Insulin from Different Sources
Some Basic Biomolecular NMR for Protein Structure Determination
Solid State NMR for Studying Membrane Proteins
Protein Complexes in SUMO Signaling
Mass Spectrometry and Glycomics
Mechanisms of Supramolecular Assembly Exemplified by Microtubules and Amyloid Fibril Formation
Hepatitis B Virus (HBV): The Life
cycle and Assembly of a Complex Virus
Photo
oxidative Stress in the Presence of a Water
soluble Derivative of C60: ESR and AFM Assay
ISBN:9781402064661
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Oncology , Bioinformatics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9781402063305:ONLINE Show nearby items on shelf
Title:Nanostructured Soft Matter [electronic resource] : Experiment, Theory, Simulation and Perspectives
Author(s): Andrei V Zvelindovsky
Date:2007
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book provides an interdisciplinary overview of a new and broad class of materials under the unifying name Nanostructured Soft Matter. It covers materials ranging from short amphiphilic molecules to block copolymers, proteins,colloids and their c omposites, microemulsions and bio-inspired systems such as vesicles. The book considers several fundamental questions, including: how self-assembly of various soft materials with internal structure at the nanoscalecan be understood, controlled and in futu re used in the newly emerging field of soft nanotechnology. The book offers readers a view on the subject from different perspectives, combining modern experimental approaches from physicalchemistry and physics with various theoretical techniques from phy sics, mathematics and the most advanced computer modelling. It is the first book of this sort in the field. All chapters are written by leading international experts,bringing together experience from Canada, Germany, Great Britain, Japan, the Netherlands, Russia, Singapore, Spain and the USA. The book is oriented towards active researchers as well as undergraduate and graduate students
Note:Springer eBooks
Contents:From the contents Preface. List of Contributors
Part I: Experimental Advances
Part II: Mathematical and Theoretical Approaches
Part III: Computer Simulations
Index
ISBN:9781402063305
Series:e-books
Series:SpringerLink (Online service)
Series:NanoScience and Technology, 1434-4904
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Physical organic , Polymers , Nanotechnology , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9781402063169:ONLINE Show nearby items on shelf
Title:Evolving Methods for Macromolecular Crystallography [electronic resource] : The Structural Path to the Understanding of the Mechanismof Action of CBRN Agents
Author(s): Randy J Read
Joel L Sussman
Date:2007
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:X-ray crystallography is the pre-eminent technique for visualizing the structures of macromolecules at atomic resolution. These structures are central to understanding the detailed mechanisms of biological processes, and todiscovering novel therapeut ics using a structure-based approach. As yet, structures are known for only a small fraction of the proteins encoded by human and pathogenic genomes. To counter the myriad modern threats of disease, there isan urgent need to determine the structures of th e thousands of proteins whose structure and function remain unknown. This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate thedramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis, and show how modernhigh-throughput methods are contributing to a deeper understanding of medical problems
Note:Springer eBooks
Contents:Preface. Succeeding with Seeding: some practical Advice
Expression, Purification and Crystallisation of membrane Proteins
Macromolecular Cryo
Crystallography
Processing Diffraction Data with Mosfim
SAD Phasing: basic Concepts and High
Throughput
Likelihood
based experimental phasing in Phaser
Stochastic molecular Replacement
Likelihood
based molecular Replacement in Phaser
Automated Structure Determination with PHENIX
Density Modification in MAIN
Ab initio Phasing starting from Low Resolution
Structural Genomics of Mycobacterium tuberculosis
a Search for Functi
ISBN:9781402063169
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science Series, 1568-2609 : v245
Series:Physics and Astronomy (Springer-11651)
Keywords: Bioinformatics , Biology Data processing , Crystallography
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9781402059001:ONLINE Show nearby items on shelf
Title:Structure and Biophysics New Technologies for Current Challenges in Biology and Beyond [electronic resource]
Author(s): Joseph D Puglisi
Date:2007
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This volume is a collection of articles from the proceedings of the ISSBMR 7th Course: Structure and Biophysics - New Technologies for Current Challenges in Biology and Beyond. This NATO Advanced Institute (ASI) was held in Ericeat the Ettore Majoran a Foundation and Centre for Scientific Culture on 22 June through 3 July 2005. The ASI brought together a diverse group of experts in the fields of Structural Biology, Biophysics and Physics. Prominent lecturers,from seven different countries, and student s from around the world participated in the NATO ASI organized by Professors Joseph Puglisi (Stanford University, USA) and Alexander Arseniev (Moscow, RU). Advances in nuclear magneticresonance spectroscopy (NMR) and x-ray crystallography have allowed the three-dimensional structures of many biological macromolecules and their complexes, including the ribosome and RNA polymerase to be solved. Fundamental principlesof NMR spectroscopy and dynamics, x-ray crystallography, computation and experimental dynami cs were taught in the context of important biological applications. The ASI addressed the treatment and detection of bioterrorism agents, andfocused on critical partner country priorities in biotechnology, materials and drug discovery. The range of topics represent the diversity of critical problems between structural biology, biochemistry and biophysics, in which lies thefertile ground of drug development, biotechnology and new materials. The individual articles represent the state of the art in each are a and provide a guide to the original literature in this rapidly developing field
Note:Springer eBooks
Contents:Preface
Structural Genomics by NMR Spectroscopy
Investigation of Proteins in Living Bacteria with in
Cell NMR Experiments
Protein
Membrane Interactions: Lessons from In Silico Studies
Anything Goes Protein Structural Polymorphism
Tandem Interactions in the trp Repressor System may Regulate Binding to Operator DNA
Basic Principles of RNA NMR Spectroscopy
Probabilistic Structure Calculation
Molecular Insights into PKR Activation by Viral Double
Stranded RNA
Structural Dynamic Approach as Rational Input for Drug Design
Max Perutz: Chemist, Molecular Biologist, Hu
ISBN:9781402059001
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science Series
Series:Physics and Astronomy (Springer-11651)
Keywords: Biotechnology , Particles (Nuclear physics) , Crystallography , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9780387689197:ONLINE Show nearby items on shelf
Title:Biological Membrane Ion Channels [electronic resource] : Dynamics, Structure, and Applications
Author(s): Shin-Ho Chung
Olaf S Andersen
Vikram Krishnamurthy
Date:2007
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem inbiology. This book dea ls with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the storyof these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.Key Features Presents the latest information on the molecular m echanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the areaof ion channel investigations
Note:Springer eBooks
Contents:Ion Channels, from Fantasy to Fact in Fifty Years1
Specific Channel Types
Gramicidin Channels: Versatile Tools
Voltage
Gated Ion Channels
Voltage
Gated Potassium Channels
BKCa
Channel Structure and Function
Voltage
Gated Sodium Channels
Calcium Channels
Chloride Transporting CLC Proteins1
Ligand
Gated Ion Channels: Permeation and Activation1
Mechanosensitive Channels
TRP Channels
Ion Channels in Epithelial Cells
Theoretical Approaches
PoissonNernstPlanck Theory of Ion Permeation Through Biological Channels
A MesoscopicMicroscopic Perspectiv
ISBN:9780387689197
Series:e-books
Series:SpringerLink (Online service)
Series:Biological And Medical Physics Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Neurosciences , Biotechnology , Biochemistry , Neurobiology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9780387688251:ONLINE Show nearby items on shelf
Title:Computational Methods for Protein Structure Prediction and Modeling [electronic resource] : Volume 2: Structure Prediction
Author(s): Ying Xu
Dong Xu
Jie Liang
Date:2007
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Volume 2 of this two-volume sequence focuses on protein structure prediction and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well asstructure prediction as a sy stems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics
Note:Springer eBooks
Contents:From the contents Homology
based structure modeling
Fold recognition of globular proteins
Ab initio protein structure prediction
Structure prediction of membrane proteins
Structure prediction of protein complexes
Protein structure
based Drug Design
Structure prediction as a systems problem
Resources for protein structure/function characterization
ISBN:9780387688251
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Proteomics , Bioinformatics
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2007-9780387683720:ONLINE Show nearby items on shelf
Title:Computational Methods for Protein Structure Prediction and Modeling [electronic resource] : Volume 1: Basic Characterization
Author(s): Ying Xu
Dong Xu
Jie Liang
Date:2007
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Volume one of this two volume sequence focuses on the basic characterization of known protein structures as well as structure prediction from protein sequence information. The 11 chapters provide an overview of the field, coveringkey topics in modeli ng, force fields, classification, computational methods, and struture prediction. Each chapter is a self contained review designed to cover (1) definition of the problem and an historical perspective, (2)mathematical or computational formulation of the pr oblem, (3) computational methods and algorithms, (4) performance results, (5) existing software packages, and (6) strengths, pitfalls, challenges, and future research directions
Note:Springer eBooks
Contents:Modeling Protein Structures
Empirical Force Fields
Knowledge
based Energy Functions for Computational Studies of Proteins
ISBN:9780387683720
Series:e-books
Series:SpringerLink (Online service)
Series:BIOLOGICAL AND MEDICAL PHYSICS BIOMEDICAL ENGINEERING, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Proteomics , Bioinformatics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540367239:ONLINE Show nearby items on shelf
Title:The Emerging Physics of Consciousness [electronic resource]
Author(s): Jack A Tuszynski
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Consciousness remains one of the major unsolved problems in science. How do the feelings and sensations making up conscious experience arise from the concerted actions of nerve cells and their associated synaptic and molecularprocesses? Can such feel ings be explained by modern science, or is there an entirely different kind of explanation needed? And how can this seemingly intractable problem be approached experimentally? How do the operations of theconscious mind emerge out of the specific interacti ons involving billions of neurons? This book seeks answers to these questions on the underlying assumption that consciousness can be understood using the intellectual potential ofmodern physics and other sciences. There are a number of theories of conscio usness, some based on classical physics while others require the use of quantum concepts. The latter ones have drawn criticism from the parts of the scientificestablishment while simultaneously claiming that classical approaches are doomed to failure. The contributing authors present a spectrum of opinions from both sides of this on-going scientific debate, allowing readers to decide forthemselves which of the approaches are most likely to succeed
Note:Springer eBooks
Contents:The Path Ahead
Consciousness and Quantum Physics: Empirical Research on the Subjective Reduction of the Statevector
Microtubules in the Cerebral Cortex: Role in Memory and Consciousness
Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins
Physicalism, Chaos and Reductionism
Consciousness, Neurobiology and Quantum Mechanics: The Case for a Connection
Life, Catalysis and Excitable Media: A Dynamic Systems Approach to Metabolism and Cognition
The Dendritic Cytoskeleton as a Computational Device: An Hypothesis
Recurrent Quantum Neural Network and its Appli
ISBN:9783540367239
Series:e-books
Series:SpringerLink (Online service)
Series:The Frontiers Collection, 1612-3018
Series:Physics and Astronomy (Springer-11651)
Keywords: Neurosciences , Neurobiology , Quantum theory
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540352846:ONLINE Show nearby items on shelf
Title:Computer Simulations in Condensed Matter Systems: From Materials to Chemical Biology Volume 2 [electronic resource]
Author(s): Mauro Ferrario
Giovanni Ciccotti
Kurt Binder
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This extensive and comprehensive collection of lectures by world-leading experts in the field introduces and reviews all relevant computer simulation methods and their applications in condensed matter systems. Volume 1, publishedas LNP 703 (ISBN 3-54 0-35270-8) is an in-depth introduction to a vast spectrum of computational techniques for statistical mechanical systems of condensed matter. It will enable the graduate student and both the specialist andnonspecialist researcher to get acquainted with th e tools necessary to carry out numerical simulations at an advanced level. The present volume is a state-of-the-art survey on numerical experiments carried out for a great number ofsystems, ranging from materials sciences to chemical biology, such as supe rcooled liquids, spin glasses, colloids, polymers, liquid crystals, biological membranes and folding proteins
Note:Springer eBooks
ISBN:9783540352846
Series:e-books
Series:SpringerLink (Online service)
Series:Lecture Notes in Physics, 0075-8450 : v704
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry , Computer science , Statistical physics , Condensed matter
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540336549:ONLINE Show nearby items on shelf
Title:The Thermodynamic Machinery of Life [electronic resource]
Author(s): Michal Kurzynski
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Living organisms are open thermodynamic systems whose functional structure has developed and been kinetically frozen during the historical process of biological evolution. A thermodynamics of both nonequilibrium and complexsystems is needed for their description. In this book, the foundations of such a thermodynamics are presented. Biological processes at the cellular level are considered as coupled chemical reactions and transport processes acrossinternal and the cytoplasmic membrane. All these proc esses are catalyzed by specific enzymes hence the kinetics of enzymatic catalysis and its control are described here in detail. The coupling of several processes through a commonenzyme is considered in the context of free energy or signal transduction. Sp ecial attention is paid to evidence for a rich stochastic internal dynamics of native proteins and its possible role in the control of enzyme activity and inthe action of biological molecular machines
Note:Springer eBooks
Contents:Introduction: Biophysics
The Physics of Animate Matter or an Experimental Tool of Biology?
Statistical Description of Matter
Thermodynamic State
Structure and Physiology of Biological Cell
Chemical Reactions
Enzymatic Catalysis
Biological Free Energy Transduction
Applicability Limits of Thermodynamics
ISBN:9783540336549
Series:e-books
Series:SpringerLink (Online service)
Series:The Frontiers Collection, 1612-3018
Series:Physics and Astronomy (Springer-11651)
Keywords: Chemistry, Organic , Biochemistry , Cytology , Thermodynamics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540307860:ONLINE Show nearby items on shelf
Title:Advanced Techniques in Biophysics [electronic resource]
Author(s): Jos Luis R Arrondo
Alicia Alonso
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Technical advancements are basic elements in our life. In biophysical studies, new applications and improvements in well-established techniques are being implemented every day. This book deals with advancements produced not onlyfrom a technical point of view, but also from new approaches that are being taken in the study of biophysical samples, such as nanotechniques or single-cell measurements. This book constitutes a privileged observatory for reviewingnovel applications of biophysical techniques t hat can help the reader enter an area where the technology is progressing quickly and where a comprehensive explanation is not always to be found
Note:Springer eBooks
Contents:Protein Nanocrystallization
Differential Scanning Calorimetry of Proteins: an Overview and Some Recent Developments
IR Reflectance
Absorbance Studies of Peptide Structure, Orientation, and Conformational Flexibility in Langmuir Films: Relevance for Models of Pulmonary Surfactant Action
Two
Dimensional Infrared Correlation Spectroscopy
NMR Spectroscopy of Large Biological Macromolecules in Solution
Emerging Techniques in Fast Multidimensional NMR
Principles and Application of Projected Multidimensional NMR Spectroscopy
G
matrix Fourier Transform NMR
Protein Nanomechanic
ISBN:9783540307860
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Biophysics, 0932-2353 : v10
Series:Physics and Astronomy (Springer-11651)
Keywords: Biochemistry , Cytology , Cytology Research_xMethodology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540291114:ONLINE Show nearby items on shelf
Title:Neutron Scattering in Biology [electronic resource] : Techniques and Applications
Author(s): Jrg Fitter
Thomas Gutberlet
John Katsaras
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. Thepresent volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers inthe field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student
Note:Springer eBooks
Contents:Neutron Scattering for Biology
Neutron Scattering for Biology
Elastic Techniques
Single Crystal Neutron Diffraction and Protein Crystallography
Neutron Protein Crystallography: Hydrogen and Hydration in Proteins
Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond
Detergent Binding in Membrane Protein Crystals by Neutron Crystallography
High
Angle Neutron Fiber Diffraction in the Study of Biological Systems
Neutron Scattering from Biomaterials in Complex Sample Environments
Small
Angle Neutron Scattering from Bio
ISBN:9783540291114
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Particle acceleration , Soft condensed matter , Physical optics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540284352:ONLINE Show nearby items on shelf
Title:Protein-Lipid Interactions [electronic resource] : New Approaches and Emerging Concepts
Author(s): C. Reyes Mateo
Javier Gmez
Jos Villalan
Jos M Gonzlez-Ros
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility thus they emerge as primary targetsin both basic and applie d research. This book brings together in a single volume the most recent views of experts in the area of proteinlipid interactions, providing an overview of the advances that have been achieved in the fieldin recent years, from very basic aspects to speci alized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understandingof the specific interactions between lipids and proteins within biologi cal membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion ofproteins and peptides into the membrane and the concomitant formation of definite lipid dom ains within the membrane
Note:Springer eBooks
Contents:From Lipid Phases to Membrane Protein Organization: Fluorescence Methodologies in the Study of Lipid
Protein Interactions
NMR of Membrane Proteins in Lipid Environments: the Bcl
2 Family of Apoptosis Regulators
X
ray and Neutron Diffraction Approaches to the Structural Analysis of Protein
Lipid Interactions
The Role of Proteins in the Formation of Domains in Membranes
Lateral Membrane Structure and Lipid
Protein Interactions
The Membrane as a System: How Lipid Structure Affects Membrane Protein Function
Peptide
Lipid Interaction: Shedding Light into the Mode of Action and Cel
ISBN:9783540284352
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Biophysics, 0932-2353 : v9
Series:Physics and Astronomy (Springer-11651)
Keywords: Bioorganic chemistry , Biochemistry , Cytology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540277040:ONLINE Show nearby items on shelf
Title:Methods in Modern Biophysics [electronic resource]
Author(s): Bengt Nlting
Date:2006
Edition:Second Edition
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Incorporating recent dramatic advances, this textbook presents a fresh and timely introduction to modern biophysical methods. An array of new, faster and higher-power biophysical methods now enables scientists to examine themysteries of life at a mol ecular level. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobilityspectrometry, mass spectrometry, proteomics, and protein folding and structure. Incorporating much information previously unavailable in tutorial form, Nlting employs worked examples and 267 illustrations to fully detail thetechniques and their underlying mechanisms. Methods in Modern Biophysics is writ ten for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in biophysics, biochemistry and related fields.Special features in the 2nd edition: Illustrates the high-resolution methods for ultrashort-living protei n structures and new results for 6 proteins. Provides information on self-evolving computer programs - a method for thesolution of extremely complex phenomena
Note:Springer eBooks
Contents:The three
dimensional structure of proteins
Liquid chromatography of biomolecules
Mass spectrometry
X
ray structural analysis
Protein infrared spectroscopy
Electron microscopy
Scanning probe microscopy
Biophysical nanotechnology
Proteomics: high throughput protein functional analysis
Ion mobility spectrometry
?
Value analysis
Evolutionary computer programming
Conclusions
ISBN:9783540277040
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Biotechnology , Chemistry, Physical organic , Medicine , Biochemistry , Bioinformatics , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9783540265658:ONLINE Show nearby items on shelf
Title:Computer Simulation Studies in Condensed-Matter Physics XVI [electronic resource]
Author(s): David P Landau
Steven P Lewis
Heinz-Bernd Schtler
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This status report features the most recent developments in the field, spanning a wide range of topical areas in the computer simulation of condensed matter/materials physics. Both established and new topics are included, rangingfrom the statistical mechanics of classical magnetic spin models to electronic structure calculations, quantum simulations, and simulations of soft condensed matter. The book presents new physical results as well as novel methods ofsimulation and data analysis. Highlights of this volume include various aspects of non-equilibrium statistical mechanics, studies of properties of real materials using both classical model simulations and electronic structurecalculations, and the use of computer simulations in teaching
Note:Springer eBooks
Contents:Computer Simulation Studies in Condensed Matter Physics: An Introduction
Shake, Rattle or Roll: Things to do with a Granular Mixture on a Computer. A New Method of Investigating Equilibrium Properties from Nonequilibrium Work
Numerical Simulations of Critical Dynamics Far from Equilibrium
Entropy Driven Phase
Separation
Supercooled Liquids under Shear: Computational Approach
Optimizing Glasses with Extremal Dynamics
Stochastic Collision Molecular Dynamics Simulations for Ion Transfer Across Liquid
Liquid Interfaces
Generalized
Ensemble Simulations of Small Proteins
A Bi
ISBN:9783540265658
Series:e-books
Series:SpringerLink (Online service)
Series:Springer proceedings in physics, 0930-8989 : v103
Series:Physics and Astronomy (Springer-11651)
Keywords: Mathematical physics , Condensed matter
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2006-9781402035005:ONLINE Show nearby items on shelf
Title:Fundamentals of Protein NMR Spectroscopy [electronic resource]
Author(s): Gordon S Rule
T. Kevin Hitchens
Date:2006
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basicunderstanding of the phen omenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set ofpractical rules is presented and used to desc ribe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding anddeveloping novel pulse programs. This text not only covers topics from ch emical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide tomany aspects of modern spectrometer hardware, sample preparation, experimental set-up, and da ta processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offerstudents a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular syst ems, but will also be a useful reference for the experienced investigator
Note:Springer eBooks
Contents:List of Figures. List of Tables. 1. Introduction To NMR Spectroscopy
2. Acquiring One
Dimensional Spectra
3. Processing One
Dimensional Spectra
4. Quantum Mechanical Description Of NMR
5. Quantum Mechanical Description Of A One Pulse Experiment
6. The Density Matrix
7. Scalar Coupling
8. Density Matrix And Product Operator of Coupled Spins
9. Two Dimensional J
Correlations
10. Heteronuclear J
Correlation Spectroscopy
11. Coherence Editing
12. Quadrature Detection In two Dimensional NMR Spectroscopy
13. Exchange Processes
14. Nuclear Spin Relaxation
15
ISBN:9781402035005
Series:e-books
Series:SpringerLink (Online service)
Series:Focus on Structural Biology, 1571-4853 : v5
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2005-9783540270768:ONLINE Show nearby items on shelf
Title:Life As a Matter of Fat [electronic resource] : The Emerging Science of Lipidomics
Author(s): Ole G Mouritsen
Date:2005
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:LIFE - as a Matter of Fat Lipidomics is the science of the fats called lipids. Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and theparticular role play ed by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as wellas pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recentstudies, an attempt is made to clarify what membrane structure is an d how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure andorganization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technologyand biomedicine are also described. The Emerging Science of Lipidomics We have just witnessed a scientific revolution at the end of the 20th century that took us through the genomics era with a focus on sequencing genes and mappinggene products. We are now in the middle of the proteomics era where the multitude of proteins that are encoded in the genes are identified an d their functions are unveiled. In front of us we have a new era recognizing the role oflipids. The science of lipidomics is emerging. Lipidomics involves a quantitative experimental and theoretical study of, e.g. lipid and membrane self-assembly, lipid-p rotein interactions, lipid-gene interactions, and the biophysicalproperties of lipid structure, function, and dynamics
Note:Springer eBooks
Contents:Prologue: Lipidomics
a Science Beyond Stamp Collection
Life From Molecules
Head and Tail
Oil and Water
Lipids Speak the Language of Curvature
A Matter of Softness
Soft Shells Shape up
Biological Membranes
Models and Fashion
Lipids in Bilayers
a Stress
Full and Busy Life
The More We are Together
Lipids in Flatland
Social Lipids
Lively Lipids Provide For Function
Proteins a Lipid Mattresses
Cholesterol on the Scene
Lipids in Charge
Being Smart
a Fishy Matter of Fat
Liquor and Drugs
As a Matter of Fat
Lipid Eaters
Powerful and
ISBN:9783540270768
Series:e-books
Series:SpringerLink (Online service)
Series:The Frontiers Collection, 1612-3018
Series:Physics and Astronomy (Springer-11651)
Keywords: Food science , Polymers , Biochemistry , Soft condensed matter , Biomedical engineering , Surfaces (Physics)
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2005-9780387272702:ONLINE Show nearby items on shelf
Title:Emergent Computation [electronic resource] : Emphasizing Bioinformatics
Author(s): Matthew Simon
Date:2005
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Emergent Computation is concerned with recent applications of Mathematical Linguistics or Automata Theory. This subject has a primary focus upon Bioinformatics (the Genome and arising interest in the Proteome), but theclosing chapter also examines ap plications in Biology, Medicine, Anthropology, etc. The book is composed of an organized examination of DNA, RNA, and the assembly of amino acids into proteins. Rather than examine these areas from apurely mathematical viewpoint (that excludes much of the biochemical reality), the author uses scientific papers written mostly by biochemists based upon their laboratory observations. Thus while DNA may exist in its double strandedform, triple stranded forms are not excluded. Similarly, while bases exist in W atson-Crick complements, mismatched bases and abasic pairs are not excluded, nor are Hoogsteen bonds. Just as there are four bases naturally found in DNA,the existence of additional bases is not ignored, nor amino acids in addition to the usual complement of 20. Can there be more than 64 possible codons? RNA is examined from the point of view of Nussinov plots. All information ispresented from the point of view of regular, context-free, and context sensitive languages, as well as Turing machines and Seque ntial Machines (and their corresponding semi-groups). Relationships to other subjects of mathematics suchas Complex numbers, Quaternions, Algebraic-Topology, and Knot Theory are also mentioned. An examination is made of Splicing Systems as well as Dominoe s. Shortcomings illustrating the dangers of mathematical abstractions that ignorebiochemistry are pointed out. The papers examine the subjects of interest from the point of view of applying language theory to search for new results, but also as biological -automatons (implementations or machines) to do calculations.This book will be of value to those studying Bioinformatics, Biochemistry, Computer-Science, Mathematical Linguistics, and Biology, as we
Note:Springer eBooks
Contents:Emergent Computation: Bioinformatics
A Review of Chemistry
A Review of Aspects of Automata Theory
The Beginning Numbers
Regular Languages: DNA and RNA
Context
Free Languages: DNA and RNA
Context
Sensitive Languages: DNA, RNA, Proteins
Turing Machines and Sub
Turing Machines
Splicing Systems, H Systems
tRNA Structure
Semigroups and Bioinformatics
Automata Theory and Disciplines Other than Bioinformatics
Automata Theory: Non
Bioinformatics Emergent Computation
ISBN:9780387272702
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Biochemical engineering , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Cover
Image
Call number:SPRINGER-2005-9780387260150:ONLINE Show nearby items on shelf
Title:Molecular and Cellular Signaling [electronic resource]
Author(s): Martin Beckerman
Date:2005
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determinewhat kinds of cells ar e made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders tocancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular andcellular signaling in biological systems with an emphasis on the unde rlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadeningtheir understanding of how cells regulate and coordinate their core activities and how dise ases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careersin biological and medical physics, bioinformatics and systems biology. To that end, the book includes backgroun d information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It haschapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specificall y devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter alsofeatures a problem set to facilitate further discussion and understanding. About the Author: Martin Beckerman, Ph.D. is Senior Scientist at the Center for Martin Beckerman, PhD, is a senior research scientist at the Department ofEnergy/National Nuclear Security Administrations Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his curre
Note:Springer eBooks
Contents:1. Introduction
2. The Control Layer
3. Exploring Protein Structure and Function
4. Macromolecular Forces
5. Protein Folding and Binding
6. Stress and Pheromone Responses in Yeast
7. Two
Component Signaling Systems
8. Organization of Signal Complexes by Lipids, Calcium and Cyclic Amp
9. Signaling by Cells of the Immune System
10. Cell Adhesion and Motility
11. Signaling in the Endocrine System
12. Signaling in the Endocrine and Nervous System through GPCRs
13. Cell Fate and Polarity
14.Cancer
15. Apoptosis
16. Gene Regulation in Eukaryotes
17. Ce
ISBN:9780387260150
Series:e-books
Series:SpringerLink (Online service)
Series:Biological and Medical Physics, Biomedical Engineering, 1618-7210
Series:Physics and Astronomy (Springer-11651)
Keywords: Medicine , Biochemistry , Cytology , Biomedical engineering
Availability:Click here to see Library holdings or inquire at Circ Desk (x3401)
Click to reserve this book Be sure to include your ID please.
More info:Amazon.com
More info: Barnes and Noble
Full Text:Click here
Location: ONLINE

Return to the Fermilab Library catalog