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SPIRES-BOOKS: FIND KEYWORD TOXICOLOGY *END*INIT* use /tmp/qspiwww.webspi1/1101.122 QRY 131.225.70.96 . find keyword toxicology ( in books using www Cover
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Call number:9780323143486:ONLINE Show nearby items on shelf
Title:Accelerator health physics [electronic resource]
Author(s): H. Wade. Patterson
Date:1973
Publisher:New York: Academic Press
Size:1 online resource
ISBN:9780323143486
Series:eBooks
Series:ScienceDirect eBook platform
Keywords: Radiation, Toxicology. , Radiation, Safety measures. , Particle accelerators
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Call number:3527338713:ONLINE Show nearby items on shelf
Title:Biomedical Applications and Toxicology of Carbon Nanomaterials
Author(s): Chen
Date:2016
Publisher:Wiley-VCH
Size:1 online resource (544 p.)
ISBN:9783527338719
Series:eBooks
Series:Wiley Online Library
Series:Wiley 2016 package purchase
Keywords: Nanotechnology
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Call number:3527337970:ONLINE Show nearby items on shelf
Title:Toxicology of Nanomaterials
Author(s): Zhao
Date:2016
Publisher:Wiley-VCH
Size:1 online resource (433 p.)
ISBN:9783527337972
Series:eBooks
Series:Wiley Online Library
Series:Wiley 2016 package purchase
Keywords: Nanotechnology
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Call number:SPRINGER-2016-9783319235585:ONLINE Show nearby items on shelf
Title:Nonclinical Statistics for Pharmaceutical and Biotechnology Industries
Author(s):
Date:2016
Edition:1st ed. 2016
Size:1 online resource (113 p.)
Note:10.1007/978-3-319-23558-5
Contents:Introduction to Nonclinical Statistics for Pharmaceutical and Biotechnology Industries -- Regulatory Nonclinical Statistics -- How to be a good nonclinical statistician -- Statistical Methods for Drug Discovery -- High-throughput Screening Data Anal ysis -- Quantitative-Structure Activity Relationship Modeling and Cheminformatics -- GWAS for Drug Discovery -- Statistical applications in Design and Analysis of In-Vitro Safety Screening Assays -- Nonclinical safety assessment: an introduction for stati sticians -- General Toxicology, Safety Pharmacology, Reproductive Toxicology and Juvenile Toxicology Studies -- Clinical Assays for Biological Macromolecules -- Recent Research Projects by FDA's Pharmacology and Toxicology Statistics Team -- Design and ev aluation of drug combination studies -- Biomarkers -- Overview of Drug Development and Statistical Tools for Manufacturing and Testing -- Assay Validation -- Lifecycle Approach to Bioassay -- Quality by Design: Building Quality into
Products and Processes -- Process Validation -- Acceptance Sampling -- Process Capability and Statistical Process Control -- Statistical Considerations for Stability and the Estimation of Shelf Life.- In Vitro Dissolution Testing: Statistical Approa ches and Issues -- Assessing Content Uniformity -- Chemometrics and Predictive Modelling -- Statistical Methods for Comparability Studies
ISBN:9783319235585
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Statistics , Pharmacology , Medicine , Statistics , Statistics for Life Sciences, Medicine, Health Sciences , Medicine/Public Health, general , Pharmacology/Toxicology
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Call number:SPRINGER-2013-9783642375552:ONLINE Show nearby items on shelf
Title:Protein-Nanoparticle Interactions [electronic resource] : The Bio-Nano Interface
Author(s): Masoud Rahman
Sophie Laurent
Nancy Tawil
L'Hocine Yahia
Morteza Mahmoudi
Date:2013
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulatesystems are of signific ant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediatelycovered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a biological identity totheir surfaces (referred to as a corona), which determines the subsequent cel lular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called bio-nano interface, has been veryrarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the impor tance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed indetail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limi tations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry,nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussi on of the possibilities for enhancing the current methods and a call fornew techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts
Note:Springer eBooks
Contents:The Biological Significance of Nano interactions
Nanoparticle and Protein Corona
Protein Corona: Applications and Challenges
Analytical Methods for Corona Evaluations
ISBN:9783642375552
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Biophysics, 0932-2353 : v15
Series:Physics and Astronomy (Springer-11651)
Keywords: Life sciences , Toxicology , Biochemistry , RNA-ligand interactions , Nanotechnology
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Call number:SPRINGER-2011-9783642201776:ONLINE Show nearby items on shelf
Title:Nanoethics and Nanotoxicology [electronic resource]
Author(s): Philippe Houdy
Marcel Lahmani
Francelyne Marano
Date:2011
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Nanobiotechnology is a fast developing field of research and application in many domains such as in medicine, pharmacy, cosmetics and agro-industry. The book addresses the lastest fundamental results on nanotoxicology andnanoethics, and the enormous range of potential applications in the fields of medical diagnostics, nanomedicine, and food and water administration. Nanoscale objects have properties leading to specific kinds of behaviour, sometimesexacerbating their chemical reactivity, physical beha viour, or potential to penetrate deeply within living organisms. Hence it is important to ensure the responsible and safe development of nanomaterials and nanotechnologies. Thisfourth volume in the Nanoscience series should make its mark, by presenting th e state of the art in the fields of nanotoxicology and nanoethics. This is the first book to combine both scientific knowledge and ethical and socialrecommendations. It also presents specific policies on nanotechnologies set up by national and internation al authorities. This book is of interest to engineers, researchers, and graduate students
Note:Springer eBooks
Contents:Management in the workplace
Health protection
Part B: Experimental toxicology of nanoparticles and their impact on the environment
surface reactivity of manufactured nanoparticles
nanoparticle transfer
ecotoxicology: reactivity in living systems
toxicological models
life cycle models
nanoethics
nano
ethics: challenges and opportunities
philosophical guidelines for the responsible use of nanotechnology
ethics and regulation
the situation in france
the situation in europe and the rest of the world
nanotechnology and the law
ISBN:9783642201776
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Toxicology , Ethics , Medical ethics , Engineering , Nanotechnology
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Call number:SPRINGER-2009-9780387096162:ONLINE Show nearby items on shelf
Title:Nonlinear Regression with R [electronic resource]
Author(s): Christian Ritz
Jens Carl Streibig
Date:2009
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:R is a rapidly evolving lingua franca of graphical display and statistical analysis of experiments from the applied sciences. Currently, R offers a wide range of functionality for nonlinear regression analysis, but the relevantfunctions, packages and documentation are scattered across the R environment. This book provides a coherent and unified treatment of nonlinear regression with R by means of examples from a diversity of applied sciences such as biology,chemistry, engineering, medicine and toxico logy. The book begins with an introduction on how to fit nonlinear regression models in R. Subsequent chapters explain in more depth the salient features of the fitting function nls(), the useof model diagnostics, the remedies for various model departures , and how to do hypothesis testing. In the final chapter grouped-data structures, including an example of a nonlinear mixed-effects regression model, are considered.Christian Ritz has a PhD in biostatistics from the Royal Veterinary and Agricultural Unive rsity. For the last 5 years he has been working extensively with various applications of nonlinear regression in the life sciences and relateddisciplines, authoring several R packages and papers on this topic. He is currently doing postdoctoral research a t the University of Copenhagen. Jens C. Streibig is a professor in Weed Science at the University of Copenhagen. He hasfor more than 25 years worked on selectivity of herbicides and more recently on the ecotoxicology of pesticides and has extensive experi ence in applying nonlinear regression models. Together with the first author he has developed shortcourses on the subject of this book for students in the life sciences
Note:Springer eBooks
Contents:Introduction
Getting started
Starting values and self starters
More on nls ()
Model diagnostics
Remedies for model variations
Uncertainty, hypothesis testing and model selection
Grouped data
Appendix A: Datasets and models
Appendix B: Self starter functions
Appendix C: Packages and functions
References
Index
ISBN:9780387096162
Series:e-books
Series:SpringerLink (Online service)
Series:Use R
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Toxicology , Epidemiology , Forests and forestry , Mathematical statistics , Engineering
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Call number:SPRINGER-2008-9781402069529:ONLINE Show nearby items on shelf
Title:Optical Waveguide Sensing and Imaging [electronic resource]
Author(s): Wojtek J Bock
Israel Gannot
Stoyan Tanev
Date:2008
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The book explores various aspects of existing and emerging fiber and waveguide optics sensing and imaging technologies including recent advances in nanobiophotonics. The focus is both on fundamental and applied research as well ason applications in c ivil engineering, biomedical sciences, environment, security and defence. The main goal of the multi-disciplinarry team of Editors was to provide an useful reference of state-of-the-art overviews covering a varietyof complementary topics on the interface of engineering and biomedical sciences
Note:Springer eBooks
ISBN:9781402069529
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science for Peace and Security Series, 1874-6500
Series:Physics and Astronomy (Springer-11651)
Keywords: Oncology , Biomedical engineering , Environmental toxicology , Biotechnology
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Call number:SPRINGER-2007-9783540345787:ONLINE Show nearby items on shelf
Title:Space Weather- Physics and Effects [electronic resource]
Author(s): Volker Bothmer
Ioannis A Daglis
Date:2007
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book is a state-of-the-art review on the physics of space weather and on space weather impacts on human technology, including manned spaceflight. With contributions from a team of international experts, this comprehensivework covers all aspects of space weather physical processes, and all known aspects of space hazards from humans, both in space and on Earth. Space Weather - Physics and Effects provides the first comprehensive, scientific background ofspace storms caused by the sun and its impac t on geospace focuses on weather issues that have become vital for the development of nationwide technological infrastructures explains magnetic storms on Earth, including the effects of EUVradiation on the atmosphere is an invaluable aid in establishing real-time weather forecasts details the threat that solar effects might have on modern telecommunication systems, including national power grid systems, aircraft andmanned spaceflight
Note:Springer eBooks
Contents:Space weather forecasting historically viewed through the lens of meteorology
The Sun as the prime source of space weather
The coupling of the solar wind to the Earths magnetosphere
Major radiation environments in the heliosphere and their implications for interplanetary travel
Radiation belts and ring current
Ionospheric response
Solar effects in the middle and lower stratosphere and probable associations with the troposphere
Space weather effects on communications
Space weather effects on power grids
Space weather impacts on space radiation protection
Effects
ISBN:9783540345787
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Praxis Books
Series:Physics and Astronomy (Springer-11651)
Keywords: Physical geography , Meteorology , Astrophysics , Climatic changes , Environmental toxicology
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Call number:SPRINGER-2007-9780387728995:ONLINE Show nearby items on shelf
Title:evaluating clinical research [electronic resource] : All that glitters is not gold
Author(s): Bengt D Furberg
Curt D Furberg
Date:2007
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader willbe able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. There are no prerequisites for reading this book. The text is basic and has no statisticalformulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points,sometimes in a provocative way. Bengt D. Furberg, MD, PhD is board-cert ified in internal medicine. After spending a decade as medical director in the pharmaceutical industry, he now serves as medical consultant, evaluating the safetyand efficacy of pharmaceutical products and medical devices and promoting evidence-based medi cine. His brother, Curt D. Furberg, MD, PhD, is Professor in the Division of Public Health Sciences, Wake Forest University School ofMedicine, Winston-Salem, NC, USA. After arriving in the United States from Sweden, he worked at the National Heart, Lung, and Blood Institute of the National Institutes of Health for 12 years. He is co-author of Fundamentals ofClinical Trials with Lawrence M. Friedman and David L. DeMets. His areas of interest are clinical trials, evidence-based medicine and drug safety. The authors have acquired much of their knowledge about clinical studies through thetrial and error method. Thus, they have personal experience with many of the problems they describe
Note:Springer eBooks
Contents:What is the Purpose of This Book?
Why is Benefit
to
Harm Balance Essential to Treatment Decisions?
What are the Strengths of Randomized Controlled Clinical Trials?
What are the Weaknesses of Randomized Controlled Clinical Trials?
Do Meta
Analyses Provide the Ultimate Truth?
What are the Strengths of Observational Studies?
What are the Weaknesses of Observational Studies?
Were the Scientific Questions Specified in Advance?
Were the Treatment Groups Comparable Initially?
Why is Blinding/Masking So Important?
How is Symptomatic Improvement Measured?
is it Really P
ISBN:9780387728995
Series:e-books
Series:SpringerLink (Online service)
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Toxicology , Quality of Life , Quality of Life Research
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Call number:SPRINGER-2007-9780387698137:ONLINE Show nearby items on shelf
Title:Permutation Methods [electronic resource] : A Distance Function Approach
Author(s): Paul W Mielke
Kenneth J Berry
Date:2007
Edition:Second
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Most commonly-used parametric and permutation statistical tests, such as the matched-pairs t test and analysis of variance, are based on non-metric squared distance functions that have very poor robustness characteristics. Thissecond edition places i ncreased emphasis on the use of alternative permutation statistical tests based on metric Euclidean distance functions that have excellent robustness characteristics. These alternative permutation techniquesprovide many powerful multivariate tests includi ng multivariate multiple regression analyses. In addition to permutation techniques described in the first edition, this second edition also contains various new permutation statisticalmethods and studies that include resampling multiple contingency table analyses, analysis concerns involving log-linear models with small samples, an exact discrete analog of Fishers continuous method for combining P-values thatarise from small data sets, multiple dichotomous response analyses, problems regarding Fishers Z transformation for correlation analyses, and multivariate similarity comparisons between corresponding multiple categories of twosamples. Paul W. Mielke, Jr. is Professor of Statistics at Colorado State University, and a fellow of the American Statistical Association. Kenneth J. Berry is Professor of Sociology at Colorado State University
Note:Springer eBooks
Contents:Introduction
Description of MRPP
Additional MRPP applications
Description of MRBP
Regression analysis, prediction, and agreement
Goodness
of
Fit tests
Contingency tables
Multisample homogeneity tests
Selected permutation studies
ISBN:9780387698137
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Statistics, 0172-7397
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Data mining , Biometrics , Mathematical statistics , Environmental toxicology , Psychometrics
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Call number:SPRINGER-2006-9783540376644:ONLINE Show nearby items on shelf
Title:Light Scattering by Optically Soft Particles [electronic resource] : Theory and Applications
Author(s): Subodh K Sharma
David J Somerford
Date:2006
Publisher:Berlin, Heidelberg : Springer Berlin Heidelberg
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The present monograph deals with a particular class of approximation methods in the context of light scattering by small particles. This class of approximations has been termed as eikonal or soft particle approximations. Theeikonal approximation was studied extensively in the potential scattering and then adopted in optical scattering problems. In this context, the eikonal and other soft particle approximations pertain to scatterers whose relativerefractive index compared to surrounding medium is clo se to unity. The study of these approximations is very important because soft particles occur abundantly in nature. For example, the particles that occur in ocean optics, biomedicaloptics, atmospheric optics and in many industrial applications can be clas sified as soft particles. This book was written in recognition of the long-standing and current interest in the field of scattering approximations for softparticles. It should prove to be a useful addition for researchers in the field of light scattering
Note:Springer eBooks
Contents:1. Introduction
2. The eikonal approximation in non relativistic potential scattering
3. The eikonal approximation in optical scattering
4. Other soft particle approximations
5. Applications
Appendices
ISBN:9783540376644
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Praxis Books
Series:Physics and Astronomy (Springer-11651)
Keywords: Physical geography , Soft condensed matter , Quantum optics , Spectrum analysis , Physical optics , Environmental toxicology
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Call number:SPRINGER-2006-9781402041679:ONLINE Show nearby items on shelf
Title:Frontiers in Planar Lightwave Circuit Technology [electronic resource] : Design, Simulation, and Fabrication
Author(s): Siegfried Janz
Jiri Ctyroky
Stoyan Tanev
Date:2006
Publisher:Dordrecht : Springer Netherlands
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book is the result of the NATO Advanced Research Workshop on Frontiers in Planar Lightwave Circuit Technology, which took place in Ottawa, Canada from September 21-25, 2004. Many of the worlds leading experts inintegrated photonic design, theory and experiment were invited to give lectures in their fields of expertise, and participate in discussions on current research and applications, as well as the new directions planar lightwave circuittechnology is evolving towards. The sum of their contrib utions to this book constitutes an excellent record of many key issues and scientific problems in planar lightwave circuit research at the time of writing. In this volume thereader will find detailed overviews of experimental and theoretical work in high index contrast waveguide systems, micro-optical resonators, nonlinear optics, and advanced optical simulation methods, as well as articles describingemerging applications of integrated optics for medical and biological applications
Note:Springer eBooks
Contents:Preface. Acknowledgements
1. Microphotonics: Current challenges and applications
2. Micro
optical resonators for microlasers and integrated optoelectronics
3. Advanced modeling of high contrast photonic structures
4. Surface plasmon resonance (SPR) biosensors and their applications in food safety and security
5. Optical biosensor devices as early detectors of biological and chemical warfare agents
6. Modelling of one
dimensional nonlinear periodic structures by direct integration of Maxwells equations in frequency domain
7. Propagation of optical pulses through non
line
ISBN:9781402041679
Series:e-books
Series:SpringerLink (Online service)
Series:NATO Science Series II: Mathematics, Physics and Chemistry, 1568-2609 : v216
Series:Physics and Astronomy (Springer-11651)
Keywords: Laser physics , Quantum optics , Physical optics , Microwaves , Environmental toxicology
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Call number:SPRINGER-2006-9780817644772:ONLINE Show nearby items on shelf
Title:Lagrangian Probability Distributions [electronic resource]
Author(s): Prem C Consul
Felix Famoye
Date:2006
Publisher:Boston, MA : Birkhuser Boston
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:Lagrangian expansions can be used to obtain numerous useful probability models, which have been applied to real life situations including, but not limited to: branching processes, queuing processes, stochastic processes,environmental toxicology, diff usion of information, ecology, strikes in industries, sales of new products, and production targets for optimum profits. This book presents a comprehensive, systematic treatment of the class of Lagrangianprobability distributions, along with some of its f amilies, their properties, and important applications. Key features: * Fills a gap in book literature * Examines many new Lagrangian probability distributions, their numerous families,general and specific properties, and applications to a variety of diffe rent fields * Presents background mathematical and statistical formulas for easy reference * Detailed bibliography and index * Exercises in many chapters Graduatestudents and researchers with a good knowledge of standard statistical techniques and an inte rest in Lagrangian probability distributions will find this work valuable. It may be used as a reference text or in courses and seminars onDistribution Theory and Lagrangian Distributions. Applied scientists and researchers in environmental statistics, re liability, sales management, epidemiology, operations research, optimization in manufacturing and marketing, andinfectious disease control will benefit immensely from the various applications in the book
Note:Springer eBooks
Contents:Preliminary Information
Lagrangian Probability Distributions
Properties of General Lagrangian Distributions
Quasi
Probability Models
Some Urn Models
Development of Models and Applications
Modified Power Series Distributions
Some Basic Lagrangian Distributions
Generalized Poisson Distribution
Generalized Negative Binomial Distribution
Generalized Logarithmic Series Distribution
Lagrangian Katz Distribution
Random Walks and Jump Models
Bivariate Lagrangian Distributions
Multivariate Lagrangian Distributions
Computer Generation of Lagrangian Variables
ISBN:9780817644772
Series:e-books
Series:SpringerLink (Online service)
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Distribution (Probability theory) , Mathematical statistics , Economics Statistics , Statistics
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Call number:SPRINGER-2006-9780387354293:ONLINE Show nearby items on shelf
Title:Statistical Analysis of Environmental Space-Time Processes [electronic resource]
Author(s): Nhu D Le
James V Zidek
Date:2006
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book provides a broad introduction to the fascinating subject of environmental space-time processes addressing the role of uncertainty. Within that context, it covers a spectrum of technical matters from measurement toenvironmental epidemiology to risk assessment. It showcases non-stationary vector-valued processes, while treating stationarity as a special case. The contents reflect the authors cumulative knowledge gained over many years ofconsulting and research collaboration. In particular, wi th members of their research group, they developed within a hierarchical Bayesian framework, the new statistical approaches presented in the book for analyzing, modeling, andmonitoring environmental spatio-temporal processes. Furthermore they indicate new directions for development. This book contains technical and non-technical material and it is written for statistical scientists as well as consultants,subject area researchers and students in related fields. Novel chapters present the authors hierarchic al Bayesian approaches to spatially interpolating environmental processes designing networks to monitor environmental processesmultivariate extreme value theory incorporating risk assessment. In addition, they present a comprehensive and critical survey o f other approaches, highlighting deficiencies that their method seeks to overcome. Special sections markedby an asterisk provide rigorous development for readers with a strong technical background. Alternatively readers can go straight to the tutorials su pplied in chapter 14 and learn how to apply the free, downloadable modeling and designsoftware that the authors and their research partners have developed. Nhu Le is a Senior Scientist in Cancer Control Research and a former Director of the Occupational O ncology Research Program at the British Columbia Cancer Agency(BCCA). An Adjunct Professor of Statistics at the University of British Columbia since 1992, he also teaches graduate courses and sup
Note:Springer eBooks
Contents:First encounters
Case study
Uncertainty
Measurement
Modelling
Covariances
Classical approaches
Bayesian kriging
Hierarchical methods
Multivariate modelling
Network design
Extremes
Risk assessment
R tutorial
ISBN:9780387354293
Series:e-books
Series:SpringerLink (Online service)
Series:Springer Series in Statistics, 0172-7397
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Epidemiology , Mathematical statistics , Environmental toxicology
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Call number:SPRINGER-2006-9780387337067:ONLINE Show nearby items on shelf
Title:Dose Finding in Drug Development [electronic resource]
Author(s): Naitee Ting
Date:2006
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the drug will not work? Can the dose be too high that it may cause somepotential problem? How do people learn about dosing information? This book answers some of these questions. Dosing information on the drug label is based on discussion and agreement between the pharmaceutical manufacturer and the drugregulatory agency. A drug label is a high le vel summary of results obtained from many scientific experiments. Scientists with biological, chemical, medical, or statistical background working in the pharmaceutical industry designed andexecuted these experiments to obtain information to help understa nd the dosing information. This book introduces the drug development process, the design and analysis of clinical trials. Many of the discussions are based onapplications of statistical methods in the design and analysis of dose response studies. Although the book is prepared mainly for statisticians/biostatisticians, it also serves as a useful reference to a variety of professionalsworking for the pharmaceutical industry. The potential readers include pharmacokienticists, clinical scientists, clinical ph armacologists, pharmacists, project managers, pharmaceutical scientists, clinicians, programmers, datamanagers, regulatory specialists, and study report writers. This book is also a good reference for professionals working in a drug regulatory environment , for example, the FDA. Scientists and/or reviewers from both U.S. and foreigndrug regulatory agencies can benefit greatly from this book. In addition, statistical and medical professionals in academia may find this book helpful in understanding the drug development process and practical concerns in selectingdoses for a new drug. Naitee Ting received his Ph. D. in statistics from Colorado State University in 1987 and joined Pfizer Research right after o
Note:Springer eBooks
Contents:Introduction And New Drug Development Process
Dose Finding Based on Pre
Clinical Studies (David Salsburg)
Dose
Finding Studies in Phase I and Estimation of Maximally Tolerated Dose
Dose
Finding In Oncology Non
Parametric Methods
Dose Response in Oncology Parametric Methods
Dose Response
Pharmacokinetic
Pharmacodynamic Approach
General Considerations in Dose Response Study Designs
Clinical Trial Simulation A Case Study Incorporating Efficacy and Tolerability Dose Response
Analysis of Dose Response Studies Emax Model
Analysis of Dose Response Studies
ISBN:9780387337067
Series:e-books
Series:SpringerLink (Online service)
Series:Statistics for Biology and Health, 1431-8776
Series:Mathematics and Statistics (Springer-11649)
Keywords: Statistics , Toxicology
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Call number:SPRINGER-2006-9780387319100:ONLINE Show nearby items on shelf
Title:Modeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics [electronic resource] : Homogeneous and Heterogeneous Approaches
Author(s): Panos Macheras
Athanassios Iliadis
Date:2006
Publisher:New York, NY : Springer New York
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to coverheterogeneous drug-biological pr ocesses and therapeutic effects in the body. The book is divided into four parts the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics the second with drugdissolution, release, and absorption the third with empirica l, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance andapplication to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. Thistimely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical scie nces, bioengineering, and physiology
Note:Springer eBooks
ISBN:9780387319100
Series:e-books
Series:SpringerLink (Online service)
Series:Interdisciplinary Applied Mathematics, 0939-6047 : v30
Series:Mathematics and Statistics (Springer-11649)
Keywords: Mathematics , Toxicology , Biochemistry , Biology Mathematics , Biomedical engineering
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Call number:SPRINGER-2006-9780387254449:ONLINE Show nearby items on shelf
Title:Quantitative Analysis in Nuclear Medicine Imaging [electronic resource]
Author(s): Habib Zaidi
Date:2006
Publisher:Boston, MA : Springer US
Size:1 online resource
Note:Springer e-book platform
Note:Springer 2013 e-book collections
Note:This book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine. Driven in part by the remarkable increase in computing power and its ready and inexpensiveavailability, this is a relatively new yet rapidly expanding field. Likewise, although the use of radionuclides for diagnosis and therapy has origins dating back almost to the discovery of natural radioactivity itself, radionuclidetherapy and, in particular, targeted radionucl ide therapy has only recently emerged as a promising approach for therapy of cancer and, to a lesser extent, other diseases. As effort has, therefore, been made to place the reviewsprovided in this book in a broader context. The effort to do this is refle cted by the inclusion of introductory chapters that address basic principles of nuclear medicine imaging, followed by overview of issues that are closely relatedto quantitative nuclear imaging and its potential role in diagnostic and therapeutic applicati ons. The different chapters discuss the basic principles and various steps required for obtaining quantitatively accurate data from nuclearmedicine images including data collection methods and algorithms used to correct them for physical degrading factors (e.g. collimator response, attenuation, scatter, partial volume effect), and image reconstruction algorithms(analytic, iterative) as well as image processing and analysis techniques as their clinical and research applications in neurology, cardiology and oncology. Some algorithms are described and illustrated with some useful features andclinical applications. Other potential applications of quantitative image analysis such as image-guided radiation therapy are also discussed
Note:Springer eBooks
Contents:Preface
Overview of nuclear medical imaging: physics and instrumentation
Dual
modality imaging: more than the sum of its parts
Analytic image reconstruction methods
Iterative image reconstruction methods
Collimator
detector response compensation in SPECT
Attenuation correction strategies in emission tomography
Scatter correction strategies in emission tomography
Correction of partial volume effects in emission tomography
Image registration techniques in nuclear medicine imaging
Image segmentation techniques in nuclear medicine imaging
Monte Carlo modeling in nucl
ISBN:9780387254449
Series:e-books
Series:SpringerLink (Online service)
Series:Physics and Astronomy (Springer-11651)
Keywords: Neurosciences , Toxicology , Cardiology , Oncology , Biomedical engineering
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Call number:SPRINGER-2004-9783662061084:ONLINE Show nearby items on shelf
Title:Biomedical Devices and Their Applications
Author(s):
Date:2004
Size:1 online resource (201 p.)
Note:10.1007/978-3-662-06108-4
Contents:1 Biomaterials in Drug Delivery -- 2 Drug Delivery Systems for Localized Treatment of Disease -- 3 Application of Protein Electrophoresis Techniques -- 4 Xenoestrogens as Endocrine Disrupters -- 5 Medical Devices
ISBN:9783662061084
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Pharmacology , Biotechnology , Endocrinology , Orthopedics , Biophysics , Biological physics , Materials science , Physics , Biophysics and Biological Physics , Characterization and Evaluation of Materials , Orthopedics , Biotechnology , Pharmacology/Toxicology , Endocrinology
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Call number:SPRINGER-2004-9783662061046:ONLINE Show nearby items on shelf
Title:Biomaterials and Tissue Engineering
Author(s):
Date:2004
Size:1 online resource (246 p.)
Note:10.1007/978-3-662-06104-6
Contents:1 Bioactive Materials and Processing -- 2 Biocompatibility of Materials -- 3 Biotechnological Applications of Inorganic Glasses -- 4 Biocomposite Materials for Biotechnology -- 5 Tissue Engineering
ISBN:9783662061046
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Pharmacology , Biotechnology , Inorganic chemistry , Orthopedics , Biophysics , Biological physics , Materials science , Physics , Biophysics and Biological Physics , Characterization and Evaluation of Materials , Inorganic Chemistry , Orthopedics , Biotechnology , Pharmacology/Toxicology
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Call number:SPRINGER-2003-9780387218663:ONLINE Show nearby items on shelf
Title:Design and Analysis of DNA Microarray Investigations
Author(s): Richard M Simon
Date:2003
Size:1 online resource (19 p.)
Note:10.1007/b97583
Contents:DNA Microarray Technology -- Design of DNA Microarray Experiments -- Image Analysis -- Quality Control -- Array Normalization -- Class Comparison -- Class Prediction -- Class Discovery
ISBN:9780387218663
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Medicine , Cancer research , Molecular biology , Pharmacology , Health informatics , Bioinformatics , Statistics , Biomedicine , Cancer Research , Bioinformatics , Statistics for Life Sciences, Medicine, Health Sciences , Molecular Medicine , Pharmacology/Toxicology , Health Informatics
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Call number:SPRINGER-1998-9781461222262:ONLINE Show nearby items on shelf
Title:Case Studies in Environmental Statistics
Author(s):
Date:1998
Size:1 online resource (3 p.)
Note:10.1007/978-1-4612-2226-2
Contents:1 Introduction: Problems in Environmental Monitoring and Assessment -- 1 Statistical Methods for Environmental Monitoring and Assessment -- 2 Outline of Case Studies -- 3 Sources of Data and Software -- Acknowledgments -- 2 Modeling
Ozone in the Chicago Urban Area -- 1 Introduction -- 2 Data Sources -- 3 Trend Analysis and Adjustment -- 4 Trends from Semiparametric Models -- 5 Trends in Exceedances -- 6 Summary -- Acknowledgments -- References -- 3 Regional and
Temporal Models for Ozone Along the Gulf Coast -- 1 Introduction -- 2 Diurnal Variation in Ozone -- 3 Meteorological Clusters and Ozone -- 4 Regional Variation in Ozone -- 5 Summary -- 6 Future Directions -- References -- 4 Design of
Air-Quality Monitoring Networks -- 1 Introduction -- 2 Data -- 3 Spatial Models -- 4 Thinning a Small Urban Network -- 5 Adding Rural Stations to Northern Illinois -- 6 Modifying Regional Networks -- 7 Scientific Contributions and
Discussion -- References -- 5 Estimating Trends in the Atmospheric Deposition of Pollutants -- 1 Introduction -- 2 Monitoring Data -- 3 Case Studies -- 4 Future Research -- Acknowledgment -- References -- 6 Airborne Particles and
Mortality -- 1 Introduction -- 2 Statistical Studies of Particles and Mortality -- 3 An Example: Data from Birmingham, Alabama -- 4 Results for Birmingham -- 5 Comparisons with Other Cities -- 6 Conclusions: Accidental Association or
Causal Connection -- References -- 7 Categorical Exposure-Response Regression Analysis of Toxicology Experiments -- 1 Introduction -- 2 The Tetrachloroethylene Database -- 3 Statistical Models for Exposure-Response Relationships -- 4
Computing Software: CatReg -- 5 Application to Tetrachloro ethylene Data -- 6 Conclusions -- 7 Future Directions -- Acknowledgments -- References -- 8 Workshop: Statistical Methods for Combining Environmental Information -- 1 The
NISS-USEPA Workshop Series -- 2 Combining Environmental Information -- 3 Combining Environmental Epidemiology Information -- 4 Combining Environmental Assessment Information -- 5 Combining Environmental Monitoring Data -- 6 Future
Directions -- References -- A Appendix A: FUNFITS, Data Analysis and Statistical Tools for Estimating Functions Douglas Nychka, Perry D. Haaland, Michael A. O’Connell, Stephen Ellner -- 1 Introduction -- 2 What’s So Special About
FUNFITS? -- 2.1 An Example -- 3 A Basic Model for Regression -- 4 Thin-Plate Splines: tps -- 4.1 Determining the Smoothing Parameter -- 4.2 Approximate Splines for Large Data Sets -- 4.3 Standard Errors -- 5 Spatial Process Models:
krig -- 5.1 Specifying the Covariance Function -- 5.2 Some Examples of Spatial Process Estimates -- Acknowledgments -- References -- B Appendix B: DI, A Design Interface for Constructing and Analyzing Spatial Designs Nancy Saltzman,
Douglas Nychka -- 1 Introduction -- 2 An Example -- 3 How DI Works -- 3.1 Network Objects -- 3.2 The Design Editor -- 3.3 User Modifications -- C Appendix C: Workshops Sponsored Through the EPA/NISS Cooperative Agreement -- D Appendix
D: Participating Scientists in the Cooperative Agreement
ISBN:9781461222262
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Lecture Notes in Statistics: 132
Keywords: Statistics , Statistics , Statistics, general
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Call number:SPRINGER-1996-9789400915411:ONLINE Show nearby items on shelf
Title:ECOtoxicology: Ecological Dimensions
Author(s):
Date:1996
Size:1 online resource (90 p.)
Note:10.1007/978-94-009-1541-1
Contents:1 Putting the ‘ECO-’ into ECOtoxicology -- 2 Ecology in ecotoxicology: some possible ‘rules of thumb’ -- 2.1 Introduction -- 2.2 Reliability -- 2.3 Relevance -- 2.4 ‘Rules of thumb’ -- 2.5 Conclusions -- References -- 3 Using
demographic theory, community ecology and spatial models to illuminate ecotoxicology -- 3.1 Introduction -- 3.2 Stage-structured demographic models as an improvement on simply counting dead animals -- 3.3 Adapting recent advances in
community ecology for predicting beyond single-species reponses in ecotoxicology -- 3.4 Using spatially explicit models to suggest how the scale and spatial patterning of a chemical stress influences its impact -- 3.5 Can ecology
better serve environmental toxicology? -- 3.6 Conclusion -- Acknowledgements -- References -- 4 Indirect effects: concepts and approaches from ecological theory -- 4.1 Introduction -- 4.2 Simple types of indirect effects -- 4.3
Empirical studies to determine indirect effects -- 4.4 Estimating magnitudes of direct and indirect effects -- 4.5 Factors affecting the propagation of indirect effects -- 4.6 Indeterminacy of ecological interactions -- 4.7 Conclusions
-- References -- 5 The dimensions of space and time in the assessment of ecotoxicological risks -- 5.1 Introduction -- 5.2 Space and time in ecotoxicology: arguments from first principles -- 5.3 Effects of temporal and spatial factors
on ecotoxicological processes -- 5.4 The next steps in ecotoxicology -- References -- 6 Coping with variability in environmental impact assessment -- 6.1 Introduction -- 6.2 The nature of environmental variation -- 6.3 Variation and
impact assessment -- 6.4 Study designs and their assumptions -- 6.5 On natural variation, pseudoreplication, power and scale -- 6.6 Conclusions -- Acknowledgements -- References -- 7 Environmental stress and the distribution of traits
within populations -- 7.1 Are responses to environmental stress general? -- 7.2 Key definitions -- 7.3 Population tolerance distributions -- 7.4 Sensitivity in toxicology -- 7.5 Sensitivity in ecology -- 7.6 Variability in asexual
versus sexual populations -- 7.7 Stress-caused changes in variability -- 7.8 Evidence for increased variability in response to stress? -- 7.9 Predicting variance changes in response to stress -- 7.10 Detecting effects of stress on
variable systems -- 7.11 Promising directions for future inquiry -- 7.12 Concluding remarks -- Acknowledgements -- References
ISBN:9789400915411
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Environment , Ecology , Ecotoxicology , Environment , Ecotoxicology , Ecology
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Call number:SPRINGER-1990-9781468458503:ONLINE Show nearby items on shelf
Title:Genetic Toxicology of Complex Mixtures
Author(s):
Date:1990
Size:1 online resource (384 p.)
Note:10.1007/978-1-4684-5850-3
Contents:Development and Application of New Methodologies Applicable to Research on Complex Environmental Mixtures -- Complex Mixtures of Genotoxicants in Air -- Identification of Genotoxic Agents in Complex Mixtures of Air Pollutants -- Human
Exposure to Airborne Mutagens Indoors and Outdoors Using Mutagenesis and Chemical Analysis Methods -- Genetic Toxicology of Airborne Particulate Matter Using Cytogenetic Assays and Microbial Mutagenicity Assays -- Indoor and Outdoor
Sources of Airborne Mutagens in Nonurban Areas -- Characterization of Mutagen Sources in Urban Particulate Matter in Gothenburg, Sweden -- Assessment of the Mutagenicity of Volatile Organic Air Pollutants Before and After Atmospheric
Transformation -- Carcinogenicity of Complex Mixtures in Air Using In Vitro and In Vivo Assays -- Contribution of Polycyclic Aromatic Hydrocarbons and Other Polycyclic Aromatic Compounds to the Carcinogenicity of Combustion Sources and
Air Pollution -- Old and New Carcinogens -- Experimental and Epidemiologic Applications to Cancer Risk Assessment of Complex Mixtures -- Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood
Combustion in Xuan Wei, China -- The Role of Nitroarenes in the Mutagenicity of Airborne Particles Indoors and Outdoors -- Complex Mixtures of Genotoxicants in Waters -- Characterization of Mutagenic Compounds Formed During
Disinfection of Drinking Water -- Genotoxic and Carcinogenic Properties of Chlorinated Furanones: Important By-products of Water Chlorination -- Assessment and Identification of Genotoxic Compounds in Water -- Methods to Measure
Genotoxins in Wastewater: Evaluation with In Vivo and In Vitro Tests -- Detection of Genotoxicity in Chlorinated or Ozonated Drinking Water Using an Amphibian Micronucleus Test -- Exposure/Effects Assessment -- The Significance of
Mutagenicity as a Criterion in Ecotoxicological Evaluations -- DNA Adducts and Related Biomarkers in Assessing the Risk of Complex Mixtures -- Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein
Adducts -- 32P-Postlabeling DNA Adduct Assay: Cigarette Smoke-induced DNA Adducts in the Respiratory and Nonrespiratory Rat Tissues -- Postlabeling Analysis of Polycyclic Aromatic Hydrocarbon: DNA Adducts in White Blood Cells of
Foundry Workers -- Protein Adducts as Biomarkers for Chemical Carcinogens -- Evaluation of DNA Binding In Vivo for Low-Dose Extrapolation in Chemical Carcinogenesis -- Cancer Risks Due to Occupational Exposure to Polycyclic Aromatic
Hydrocarbons: A Preliminary Report -- Future Directions in Research on the Genetic Toxicology of Complex Mixtures
ISBN:9781468458503
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 39
Keywords: Medicine , Human genetics , Pharmacology , Ecotoxicology , Waste management , Biomedicine , Pharmacology/Toxicology , Human Genetics , Waste Management/Waste Technology , Ecotoxicology
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Call number:SPRINGER-1986-9781468450651:ONLINE Show nearby items on shelf
Title:A Primer of Human Behavioral Pharmacology
Author(s): Alan Poling
Date:1986
Size:1 online resource (246 p.)
Note:10.1007/978-1-4684-5065-1
Contents:1 Historical Origins of Behavioral Pharmacology -- What Is Behavioral Pharmacology? -- Drugs and Psychiatry -- Drug Abuse, LSD, and Behavioral Pharmacology -- Behavioral Toxicology -- Pharmacology and Behavioral Pharmacology --
Milestones in Behavioral Pharmacology -- Concluding Comments -- 2 Basic Principles of Pharmacology -- Labeling and Classification of Drugs -- Physical Properties of Drugs -- The Fate of a Drug -- Absorption and Route of Administration
-- Distribution of Drugs -- Biotransformation and Elimination -- Drug Kinetics and Dose-Dependent Drug Effects -- Time Course of Drug Action -- Tolerance and Physical Dependence -- Drugs, Receptors, and Neuronal Activity -- Drug
Interactions -- Individual Differences -- Concluding Comments -- 3 Overview of Behavioral Psychology -- Science and Behavioral Psychology -- Respondent Conditioning -- Operant Conditioning -- Nonhuman Research, Human Research, and
Meaningful Inference -- Concluding Comments -- 4 Stimulus Properties of Drugs -- Drugs as Unconditional and Conditional Stimuli -- Distinguishing Discriminative Stimulus Functions of Drugs -- Drugs as Positively Reinforcing Stimuli --
Drugs as Negatively Reinforcing Stimuli -- Patient Noncompliance -- Determinants of Negative Reinforcement -- Concluding Comments -- 5 Drug-Behavior Interactions -- Drug Effects on Learning -- Drug Effects on Stimulus-Controlled
Behavior -- Rate-Dependent Drug Effects -- Consequence-Dependent Drug Effects -- Concluding Comments -- 6 Clinical Drug Assessment -- Psychiatric Diagnosis -- Target Behaviors and Their Assessment -- Experimental Designs and Strategies
-- Concluding Comments -- 7 Drug Abuse -- Drugs as Positive Reinforcers -- Drug Abuse as an Operant Response -- Treating Drug Abuse -- Concluding Comments -- 8 The Future -- References
ISBN:9781468450651
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Psychology , Clinical psychology , Psychology , Clinical Psychology
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Call number:SPRINGER-1984-9781461323990:ONLINE Show nearby items on shelf
Title:Mutation, Cancer, and Malformation
Author(s):
Date:1984
Size:1 online resource (855p p.)
Note:10.1007/978-1-4613-2399-0
Contents:Genetic Factors in Human Diseases -- Environmental mutagenesis and disease in human populations -- Clinical genetics of human cancer -- Chromosome abnormalities in cancer development -- Mutations of cellular oncogenes as a basis for
neoplastic change -- Human gene mapping in the analysis of oncogenes -- Basic Concepts in Mutagenesis and Carcinogenesis -- Relationship between mutagenesis and carcinogenesis -- Theoretical basis of mutagenesis -- DNA repair processes
-- The Role of DNA repair in mutation induction -- Use of the Bacilussubtilus Rec-assay in environmental mutagen studies -- Mutagenesis in yeasts -- A comparison of genotoxic activity in somatic tissue and in the germ cells of
Drosophilamelanogaster -- The P-factor: a transposable element in Drosophila -- Silkworm genetics and chemical mutagenesis -- Mutation induction and detection in Arabidopsis -- Mutagenesis studies with cultured mammalian cells:
problems and prospects -- The control of cell transformation, mutagenesis and differentiation by chemicals that initiate or promote tumor formation -- Dominant-lethal mutations and heritable translocations in mice -- Recessive and
dominant mutations in mice -- Benzo (a)pyrene and 6-nitrobenzo (a) pyrene metabolism in human and rodent microsomes and tissue culture -- Nitrosamine metabolism and carcinogenesis -- Modification of carcinogenesis by dietary and
nutritional factors -- Naturally occurring mutagens -- Reproductive Toxicology -- Teratogenesis -- A possible mechanistic link between teratogenesis and carcinogenesis: inhibited intercellular communication -- Gem cell toxicity:
significance in genetic and fertility effects of radiation and chemicals -- Environmental Toxicology, Mutagenesis, and Carcinogenesis -- The science of toxicology — scope, goals and four case studies -- Mutagenicity of pesticides --
Genetic toxicology of 14 agents casually associated with cancer in humans -- Sensitivity, specificity and accuracy of the Arabidopsis assay in the identification of carcinogens -- Environmental studies in Sweden -- Research progress on
environmental mutagenesis, carcinogenesis and teratogenesis in China -- A. Strategy of approach to cancer control in China -- Toxicological research in public health: the Chinese experience -- Environmental mutagenesis research at
Fudan University -- The role of risk assessment in regulatory decisions in the United States -- Alternate methods for integrated evaluation of toxicity and risk assessment -- Posters
ISBN:9781461323990
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 31
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1983-9789400971974:ONLINE Show nearby items on shelf
Title:Mobile Source Emissions Including Policyclic Organic Species
Author(s):
Date:1983
Size:1 online resource (402 p.)
Note:10.1007/978-94-009-7197-4
Contents:Catalytic Control of Motor Vehicle Exhaust Emissions -- Polycyclic Organic Matter in the Atmosphere, POM Concentrations in the Netherlands -- PAH Content of Exhaust Gases from Fuels with Different Aromatic Fraction -- The Aromatic
Sextet -- Effect of Lead Antiknock Regulations on Gasoline Aromatics and Aromatic Exhaust Emissions -- The Toxicology of Polycyclic Organic Matter from Exhaust Gases -- Automotive Lead Traps: Potential under Canadian Conditions --
Carcinogenic Impact from Automobile Exhaust Condensate and the Dependence of the PAH-Profile on Various Parameters -- Recent Advances in Epa’S Monitoring and Methods Development Research -- Standardisation Aspects in PAH/POM Analysis
-- Public Health Aspects of Polyaromatic Hydrocarbons (PAH) in Belgium and Reflections on the Problem Related to the PAH in Exhaust Gases -- The PAH-Emission of Spark Ignition Engines -- Evaluation of Motor Vehicle and other Combustion
Emissions using Short-Term Genetic Bioassays -- Passenger Car PAH Emissions as a Function of Engine Displacement, Fuel, and Driving Cycle -- Actions of the European Communities in the Domain of Air Pollution Caused by Hydrocarbons --
Comparison of NITRO-Aromatic Content and Direct-Acting Mutagenicity of Passenger Car Engine Emissions -- The Influence of Fuel Composition on PAH-Emission a Methodical Consideration -- Environmental Carcinogens — Selected Methods of
Analysis: Iarc Manual Series including POM Measurements -- Biologically Active NITRO-PAH Compounds in Extracts of Diesel Exhaust Particulate -- Vehicle Emission Controls and Energy — the Role of Aromatics and Lead Compounds --
Mechanisms of PAH Formation and Destruction in Flames Relation to Organic Particulate Emissions -- PAH Emission from Various Sources and their Evolution over the Last Decades -- The Identification and Potential Sources of Nitrated
Polynuclear Aromatic Hydrocarbons (NITRO-PAH) in Diesel Particulate Extracts -- Trends in Transportation Fuels -- Modern PAH-Analysis and Fate of PAH in Air -- The Rational Utilisation of Fuels in Private Transport (Rufit) —
Extrapolation to Unleaded Gasoline Case, Report 8/80 -- Summary Chapter-NATO Advanced Research Workshop-Mobile Source Emissions including Polycyclic Organic Species -- Author Index
ISBN:9789400971974
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO ASI Series, Series C: Mathematical and Physical Sciences: 112
Keywords: Environment , Air pollution , Environment , Atmospheric Protection/Air Quality Control/Air Pollution
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Call number:SPRINGER-1983-9781468488302:ONLINE Show nearby items on shelf
Title:Old and New Questions in Physics, Cosmology, Philosophy, and Theoretical Biology Essays in Honor of Wolfgang Yourgrau
Author(s):
Date:1983
Size:1 online resource (920 p.)
Note:10.1007/978-1-4684-8830-2
Contents:A: Current Problems in Physics and Cosmology -- 1 • On The Connections Between PICO- and Mega-Cosmos (According To The Unification and Geometrization Suggested by Einstein, Eddington, and Schrödinger -- 2 • The Zitterbewegung and The
Einstein A Coefficient of Spontaneous Emission -- 3 • Supersymmetry Groups -- 4 • Relativistic Phase Space Arising out of the Dirac Algebra -- 5 • Why Mourn the Passing of Determinacy -- 6 • On The True Ideas Underlying Wave Mechanics
-- 7 • CPT Invariance as Basic for Interpreting Quantum Mechanics -- 8 • The Hilbert Space Axiom in Quantum Mechanics -- 9 • The Cyclotron-Soliton Model of Terrestrial Kilometric Radiation -- 10 • Clumpy Irregular Galaxies: A Progress
Report -- 11 • The Aporias of Cosmology and The Attempts at Overcoming Them by Nonstandard Models -- 12 • On Relativistic Quantum Theory -- 13 • Vacuum Tunneling in Static Space-Times -- 14 • On The Extensions of General Relativity --
15 • Status and Perspectives of Cosmology -- 16 • The Connection Between The Objective Description of Macrosystems and Quantum Mechanics of “ Many Particles” -- 17 • The Current Theory of Strong interactions and The Problem of Quark
Confinement -- 18 • Statistical Inference by Minimal Bures Distances -- 19 • The Knots of Quantum Thermodynamics -- 20 • About The Facts of Cosmological Significance -- 21 • Stochastic Interpretation of Relativistic Quantum Equations
-- 22 • New Quantum Mechanics -- 23 • On Nonlinear Classical Dirac Fields and Quantum Physics -- 24 • Elementary Particles as Microuniverses -- 25 • Precision Mathematics and Approximation Mathematics in Physics -- 26 • Electroweak
interaction in Polarized Electron-Positron and Electron-Electron Scattering -- 27 • Infinity and the Natural World -- 28 • Induced Superfluorescence and the Nature of the Wave- Particle Duality -- 29 • Breakdown of Predictability: an
Investigation into the Nature of Singularities -- 30 • Wave Functions in One-Dimensional Disordered Systems with Long-Range Hopping -- 31 • Perception of Quantum Systems -- 32 • Stochastic Electrodynamics: an Overview -- 33 • On The
Increase of Entropy in The Carleman Model II -- 34 • The Klein Paradox Revisited -- 35 • Einstein Nonlocality, Space-Time Structure, and Thermodyanics -- B. Issues in Biology, Philosophy, and the History of Science -- 1 • Biology and
Physics: Reflections on Reductionism -- 2 • The Age of Analysis Reassessed -- 3 • Transphyletic Animal Similarities and Predictive Toxicology -- 4 • The Wronging of Wright -- 5 • On The Historical Development of the
IndisTinguishability Concept for Microparticles -- 6 • Philosophical Semantics -- 7 • Social Exemplifications of Physical Principles -- 8 • Seneca’s Ethics Viewed From A Modern Standpoint -- 9 • Physics and Philosophy -- 10 • Einstein,
Spinoza, and God -- 11 • The Satellites of Jupiter, From Galileo to Bradley -- 12 • Emergent Properties -- 13 • The Theory of Relativity and Our World View -- 14 • Science Beyond Science -- 15 • God as Cosmic Guest-Worker -- 16 • A
Model of Reality as Mind -- 17 • A Matter of Chance -- 18 • On The Nature and Origin of Life -- 19 • Science, History, Philosophy, and World Views -- 20 • Queries About Inquiries -- 21 • The Nature of The Physical World -- 22 • Early
Attempts at A Unitary Understanding of Nature -- Name Index
ISBN:9781468488302
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Keywords: Physics , Philosophy and science , Materials science , Physics , Physics, general , Philosophy of Science , Characterization and Evaluation of Materials
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Call number:SPRINGER-1983-9781468444636:ONLINE Show nearby items on shelf
Title:Soot in Combustion Systems and Its Toxic Properties
Author(s):
Date:1983
Size:1 online resource (433 p.)
Note:10.1007/978-1-4684-4463-6
Contents:Session -- Soot Components as Genetic Hazards -- The Toxicology of Soot -- A Comparative Study of Soot and Carbon Black -- Polycyclic Aromatic Hydrocarbons and Soot From Practical Combustion Systems -- Mechanisms of Soot Formation and
Burnout -- Structure of Sooting Flames -- Chemistry of Intermediate Species in the Rich Combustion of Benzene -- Radical Chemistry in Sooting Flames -- Soot Particle Nucleation and Agglomeration -- Kinetic Aspects of Diesel Soot
Coagulation -- Mass Growth of Soot -- Ionic Mechanisms of Soot Formation -- Charged Soot Particles in Unseeded and Seeded Flames -- Electrical Intervention in the Sooting of Flames -- Burnout of Soot Particles -- Aerodynamics of Sooty
Flames -- Aerothermochemistry of Diffusion Flames -- Soot Formation and Burn-out in Turbulent Coal Liquid Fuel Flames -- Optical Diagnostics -- Theoretical Models for the Interpretation of Light Scattering by Particles Present in
Combustion Systems -- Laser Light Scattering and Fluorescence in Fuel Rich Flames: Techniques and Selected Results -- The Status of the Art in Soots Diagnosis by Means of Diffusion Broadening Spectroscopy -- The Quasi-Elastic
Scattering of Light: A Lecture with Emphasis on Particulate Diagnosis -- Synthesis and Recommendations for Future Work
ISBN:9781468444636
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:NATO Conference Series, VI Materials Science : 7
Keywords: Chemistry , Chemical engineering , Chemistry , Industrial Chemistry/Chemical Engineering
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Call number:SPRINGER-1983-9781461335993:ONLINE Show nearby items on shelf
Title:Human and Environmental Risks of Chlorinated Dioxins and Related Compounds
Author(s):
Date:1983
Size:1 online resource (823 p.)
Note:10.1007/978-1-4613-3599-3
Contents:Definition of the Problem -- Dioxins as Contaminants of Herbicides: The U. S. Perspective -- Dioxins as Contaminants of Herbicides: Australian Perspective -- The Use of Scientific Information in the Development of Public Policies --
Regulatory Actions on Dioxins and Related Compounds -- Dioxins and Related Compounds as International Issues of Concern -- Analytical Chemistry -- Analytical Methodology for the Determination of PCDDs and PCDFs in Products and
Environmental Samples: An Overview and Critique -- High Resolution Mass Spectrometry Methods of Analysis for Chlorinated dibenzo-p-dioxins and dibenzofurans -- Determination of tetrachlorodibenzo-p-dioxins and tetra-chlorodibenzofurans
in Environmental Samples by High Performance Liquid Chromatography, capillary gas chromatography and High Resolution Mass Spectrometry -- Methodology and Preliminary Results for the Isomer-Specific Determination of TCDDs and Higher
Chlorinated Dibenzo-p-dioxins in Chimney Particulates from Wood-Fueled Domestic Furnaces Located in Eastern, Central, and Western Regions of the United States -- Sampling and Analytical Methodologies for PCDDs and PCDFs in Incinerators
and Wood Burning Facilities -- Comparative Monitoring and Analytical Methodology for 2,3,7,8-TCDD in Fish -- Environmental Chemistry -- Emissions of PCDDs and PCDFs from Combustion Sources -- Changes in Dioxin Isomer Group Ratios in
the Environment: An Update and Extension of the Present Theory -- Analyses for 2,3,7,8-Tetrachlorodbenzo-p-dioxin Residues in Environmental Samples -- Long-Term Studies on the Persistence and Movement of TCDD in a Natural Ecosystem --
Microbial Degradation of TCDD in a Model Ecosystem -- Residues of Polychlorinated Dibenzo-p-dioxins and Dibenzo-furans in the Laurentian Great Lakes Fish -- Identification of Polychlorinated Dioxins (PCDDs) and Dibenzofurans (PCDFs) in
Human Samples, Occupational Exposure and Yusho Patients -- Seveso — An Environmental Assessment -- Environmental Toxicology -- Environmental Toxicity of TCDD -- The Theory of Accumulation and Its Relationship to the Choice of
Monitoring Matrices for Dioxins -- A Field Study of Soil and Biological Specimens from a Herbicide Storage and Aerial-Test Staging Site Following Long-Term Contamination with TCDD -- Chick Edema Disease and Hepatic Porphyria in Lake
Ontario Herring Gull Embryos in the Early 1970s -- Long-Term Field Studies of a Rodent Population Continuously Exposed to TCDD -- Ultrastructural Comparison of Liver Tissues from Field and Laboratory TCDD-Exposed Beach Mice --
Biochemistry and Metabolism -- PCDDs and Related Compounds: Metabolism and Biochemistry -- 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Weight Loss: A Proposed Mechanism -- Studies of the Mechanism of Action of Hepatotoxicity of
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds -- The Ah Receptor: A Specific Site for Action of Chlorinated Dioxins? -- Genetic Differences in Enzymes Which Metabolize Drugs, Chemical Carcinogens, and Other
Environmental Pollutants -- Factors Affecting the Disposition and Persistence of Halogenated Furans and Dioxins -- Adipose Tissue Storage of Polychlorinated Compounds -- Structure Elucidation of Mammalian TCDD-Metabolites -- Animal
Toxicology -- Absorption, Distribution and Metabolism of 2,3,7,8-Tetra-chlorodibenzodioxin (TCDD) in Experimental Animals -- Morphology of Lesions Produced by the Dioxins and Related Compounds -- A Consideration of the Mechanism of
Action of 2,3,7,8-Tetra-chlorodibenzo-p-dioxin and Related Halogenated Aromatic Hydrocarbons -- Human Observations -- Methodology of Clinical Studies on Exposed Populations -- A Mortality Study of Workers Employed at the Monsanto
Company Plant in Nitro, West Virginia -- Dioxin and Reproductive Events -- Significance of Cutaneous Lesions in the Symptomatology of Exposure to Dioxins and Other Chloracnegens -- Soft Tissue Sarcomas: Clues and Caution -- Risk
Assessment -- Risk Assessment: Introductory Remarks -- Assessing Risk in Legal Proceedings: How to Deal With Scientific Uncertainty in Toxic Substances Risk Assessments -- Some General Observations on the Safety of PCDDs -- Risk
Assessment for Regulation of Dioxin (TCDD) -- Risk Assessment for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) -- Laboratory Safety and Waste Management -- An Overview of Laboratory and Waste Management Guidelines for Toxic Chlorinated
Dibenzo-p-dioxins and Dibenzofurans -- Laboratory Design Considerations for the Handling and Analysis of Chlorinated Dioxins and Related Compounds -- Safe Handling of Toxic Chemicals: Perspectives of a Bench Chemist and Laboratory
Manager -- Safety Precautions for the Handling of TCDD -- A Program for Monitoring Potential Contamination in the Laboratory Following the Handling and Analyses of Chlorinated Dibenzo-p-dioxins and Dibenzofurans -- A Medical
Surveillance Program for Scientists Exposed to Dioxins and Furans -- Laboratory Handling and Disposal of Chlorinated Dioxin Wastes -- Physical and Chemical Properties of Dioxins in Relation to their Disposal -- The Design,
Implementation and Evaluation of the Industrial Hygiene Program Used During the Disposal of Herbicide Orange -- Panel Reports -- Analytical Chemistry -- Environmental Chemistry -- Environmental Toxicology -- Biochemistry and Metabolism
-- Animal Toxicology -- Human Observations -- Laboratory Safety and Waste Management -- Author Index
ISBN:9781461335993
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 26
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1983-9781461335665:ONLINE Show nearby items on shelf
Title:In Vitro Toxicity Testing of Environmental Agents Current and Future Possibilities Part A: Survey of Test Systems
Author(s):
Date:1983
Size:1 online resource (553 p.)
Note:10.1007/978-1-4613-3566-5
Contents:A: Survey of Test Systems -- I. Mutagenesis Testing: Prokaryotic Systems -- Molecular Mechanisms of Mutagenesis and Chromosomal Carcinogenesis: A Suimnary Review -- Molecular Principles Underlying the Ames Salmonella/Microsome Test:
Elements and Design of Short-Term Mutagenesis Tests -- Bacillus subtilis Rec-Assay With and Without Metabolic Activation: Improvements and Applications -- A Simple, Forward Selection Scheme for Independently Determining the Toxicity
and Mutagenic Effect of Environmental Chemicals: Measuring Replica- tive Killing of Escherichia coli by an Integrated Fragment of Bacteriophage Lambda DNA -- The Use of Salmonella Bacteriophage P22 To Study the Multiple Mechanisms of
Acridine-Induced Damage -- II. Mutagenesis Testing: Eukaryotic Systems -- Use of a Ciliated Protozoan as a Model System To Detect Toxic and Carcinogenic Agents -- In Vivo Assay To Screen for Mutagens/Carcinogens in the Nematode C.
elegans -- The Maize-Microbe Bioassay: A Unique Approach to Environmental Mutagenesis -- Mutagenicity of Ambient Air at Selected Sites in the United States Using Tradescantia as a Monitor -- Tradescantia Micronuclei (TRAD-MCN) Test for
Environmental Clastogens -- Metabolic Activation and Mutagenic Properties of Procarcinogens in Drosophila -- Mammalian Cell Mutagenesis: Relevance for Detection of Environmental Mutagens/Carcinogens -- Quantitative Mammalian Cell
Mutagenesis and Mutagen Screening: Study With Chinese Hamster Ovary Cells -- III. In Vitro Carcinogenesis Testing -- In Vitro Carcinogenesis With Cell Lines -- Modulation of Induced Quantitative Mammalian Cell Transformation --
Chemical Carcinogenesis In Vitro: Limitations and Possibilities in the Use of Rat Liver Epithelial Cells for Screening Carcinogens -- IV. Neurobehavioral Toxicity Testing -- Behavioral Assays in environmental Toxicology -- Prenatal
Exposure to Environmental Chemicals as a Test System for Neurotoxicology -- Mechanisms in Heavy Metal Toxicity -- Use of Cultures of Neuroblastoma and Glioma as a Model System To Study the Heavy Metal-Induced Neurotoxicity --
Neurochemical Approaches to Toxicity Testing: Artificial Food Dyes -- In Vitro Approaches to Neurotoxicity--A Physiologist’s Perspective -- V. End-Organ Toxicity Testing -- Migration Inhibition of Alveolar Macrophages: An Assay System
for Evaluating Toxicity of Pollutant Chemicals -- Environmental Factors in Renal Disease -- Indexes (Combined for Part A and Part B volumes) -- Author Index
ISBN:9781461335665
Series:eBooks
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Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1979-9781468436112:ONLINE Show nearby items on shelf
Title:Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures
Author(s):
Date:1979
Size:1 online resource (588 p.)
Note:10.1007/978-1-4684-3611-2
Contents:Section 1: Short-Term Bioassay Systems—An Overview -- The Use of Microbial Assay Systems in the Detection of Environmental Mutagens in Complex Mixtures -- Mutagenesis of Mammalian Cells by Chemical Carcinogens After Metabolic
Activation -- Oncogenic Transformation of Mammalian Cells by Chemicals and Viral-Chemical Interactions -- Higher Plant Systems as Monitors of Environmental Mutagens -- The Role of Drosophila in Chemical Mutagenesis Testing -- The
Cellular Toxicity of Complex Environmental Mixtures -- Section 2: Collection and Chemical Analysis of Environmental Samples -- Atmospheric Genotoxicants—What Numbers Do We Collect? -- State-of-the-Art Analytical Techniques for Ambient
Vapor Phase Organics and Volatile Organics in Aqueous Samples from Energy-Related Activities -- Strategy for Collection of Drinking Water Concentrates -- Section 3: Current Research -- Short-term Bioassay of Complex Organic Mixtures:
Part I, Chemistry -- Short-term Bioassay of Complex Organic Mixtures: Part II, Mutagenicity Testing -- Quantitative Mammalian Cell Genetic Toxicology: Study of the Cytotoxicity and Mutagenicity of Seventy Individual Environmental
Agents Related to Energy Technologies and Three Subfractions of a Crude Synthetic Oil in the CHO/HGPRT System -- Environmental Testing -- Integrating Microbiological and Chemical Testing into the Screening of Air Samples for Potential
Mutagenicity -- Chemical and Microbiological Studies of Mutagenic Pollutants in Real and Simulated Atmospheres -- Application of Bioassay to the Characterization of Diesel Particle Emissions -- Measurement of Biological Activity of
Ambient Air Mixtures Using a Mobile Laboratory for In Situ Exposures: Preliminary Results from the Tradescantia Plant Test System -- Physical and Biological Studies of Coal Fly Ash -- Mutagenicity of Shale Oil Components -- Mutagenic
Analysis of Drinking Water -- In Vitro Activation of Cigarette Smoke Condensate Materials to Their Mutagenic Forms -- Mutagenic, Carcinogenic, and Toxic Effects of Residual Organics in Drinking Water -- Mutagenic Analysis of Complex
Samples of Aqueous Effluents, Air Particulates, and Foods
ISBN:9781468436112
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 15
Keywords: Physics , Physics , Physics, general
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Call number:SPRINGER-1978-9781461589488:ONLINE Show nearby items on shelf
Title:Pentachlorophenol Chemistry, Pharmacology, and Environmental Toxicology
Author(s):
Date:1978
Size:1 online resource (402 p.)
Note:10.1007/978-1-4615-8948-8
Contents:I. Usage Patterns and Environmental Fate of Pentachlorophenol -- Patterns of Pentachlorophenol Usage in Canada — An Overview -- Patterns of Pentachlorophenol Usage in the United States of America — An Overview -- Photolysis of
Pentachlorophenol in Water -- Degradation of Pentachlorophenol in Soil, and by Soil Microorganisms -- The Fate of Pentachlorophenol in an Aquatic Ecosystem -- The Environmental Fate of 14C-Pentachlorophenol in Laboratory Model
Ecosystems -- II. Pharmacology and Toxicology of Pentachlorophenol -- A. Metabolism -- Microbial Metabolism of Pentachlorophenol -- Fate of Pentachlorophenol in the Blue Crab, Callinectes sapidus -- Metabolism of Pentachlorophenol in
Fishes -- Studies on the Uptake, Disposition and Metabolism of Pentachlorophenol and Pentachloroanisole in Rainbow Trout (Salmo gairdneri) -- Dechlorination of Pentachlorophenol in vivoandin vitro -- Pentachlorophenol in Different
Species of Vertebrates after Administration of Hexachlorobenzene and Pentachlorobenzene -- B. Comparative Toxicology and Pharmacology -- Toxicity of Pentachlorophenol and Related Compounds to Early Life Stages of Selected Estuarine
Animals -- Effects of Sodium Pentachlorophenate on Several Estuarine Animals: Toxicity, Uptake and Depuration -- Effects of Dowicide® G-ST on Development of Experimental Estuarine Macrobenthic Communities -- Effects of
Pentachlorophenol on the Meiobenthic Nematodes in an Experimental System -- Effect of Sodium Pentachlorophenate on the Feeding Activity of the Lugworm, Arenicola cristata Stimpson -- Toxicity of Sodium Pentachlorophenate to the Grass
Shrimp, Palaemonetes pugio, in Relation to the Molt Cycle -- Inhibition of Limb Regeneration in the Grass Shrimp, Palaemonetes pugio, by Sodium Pentachlorophenate -- Effect of Sodium Pentachlorophenate on Exoskeletal Calcium in the
Grass Shrimp, Palaemonetes pugio -- Ultrastructural Changes Induced by Sodium Pentachlorophenate in the Grass Shrimp, Palaemonetes pugio, in Relation to the Molt Cycle -- Effects of Sodium Pentachlorophenate and 2,4-Dinitrophenol on
Respiration in Crustaceans -- Effects of Sodium Pentachlorophenate and 2,4-Dinitrophenol on Hepatopancreatic Enzymes in the Blue Crab, Callinectes sapidus -- Effect of Pentachlorophenol on the ATPases in Rat Tissues -- Effects of
Sodium Pentachlorophenate on Survival and Energy Metabolism of Embryonic and Larval Steelhead Trout -- Results of Two-Year Toxicity and Reproduction Studies on Pentachlorophenol in Rats -- III. Chlorophenols and Their Contaminants:
Chemistry, Toxicology, Environmental Residues and Environmental Impact -- Impurities in Commercial Products Related to Pentachlorophenol -- Genetic Activity of Chlorophenols and Chlorophenol Impurities -- Negative Chemical Ionization
Mass Spectrometry: Applications in Environmental Analytical Chemistry -- Human Exposure to Pentachlorophenol -- Survey of Pesticide Residues and Their Metabolites in Urine from the General Population -- Health Implications of
2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure in Primates -- Renal Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin -- Environmental Impact of Pentachlorophenol and Its Products—A Round Table Discussion
ISBN:9781461589488
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:Environmental Science Research : 12
Keywords: Environment , Air pollution , Environment , Atmospheric Protection/Air Quality Control/Air Pollution
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Call number:SPRINGER-1975-9789401018456:ONLINE Show nearby items on shelf
Title:A Modern Course on Statistical Distributions in Scientific Work Volume 2 — Model Building and Model Selection Proceedings of the NATO Advanced Study Institute held at the University of Calgary, Calgary, Alberta, Canada July 29 – August 10, 1974
Author(s):
Date:1975
Size:1 online resource (399 p.)
Note:10.1007/978-94-010-1845-6
Contents:1. Modelling and Simulation -- 1.1 Statistical Modelling: An Alternative View -- 1.2 Chance Mechanisms for Discrete Distributions in Scientific Modelling -- 1.3 Random Numbers: The Need, the History, the Generators -- 1.4 Chance
Mechanisms in the Computer Generation of Random Variables -- 1.5 A Probability Distribution with Applications to Monte Carlo Simulation Studies -- 2. Model Indentification and Discrimination -- 2.1 On the Discrimination Between Two
Location and Scale Parameter Models -- 2.2 Applications of Characterizations in the Area of Goodness of Fit -- 2.3 Test for Normality Using a Characterization -- 2.4 Tests for Normality Using Minimum Chi-Square -- 2.5 A New Statistic
for Testing an Assumed Distribution -- 2.6 The Poisson Distribution: The Theory and Application of Some Conditional Tests -- 3. Models in the Social Sciences and Management -- 3.1 The Size of Human Settlements -- 3.2 Statistical Models
for Personal Income Distributions -- 3.3 Symmetric Distributions With Fat Tails: Interrelated Compound Distributions Estimated by Box-Jenkins Methods -- 3.4 A Marketing Application of a Characterization Theorem -- 4. Models in the
Physical and Biomedical Sciences -- 4.1 Statistical Problems of Size and Shape,I -- 4.2 Statistical Problems of Size and Shape,II -- 4.3 Skew Distributions in Biomedicine Including Some With Negative Powers of Time -- 4.4 Models in
Medicine and Toxicology -- 4.5 Mass-Size Distributions — A Review and a Proposed New Model -- 4.6 Application of Statistical Models to Engineering Problems -- 4.7 Failure and Mortality from Wear and Ageing. The Teissier Model -- 4.8
Some Statistical Models for Seismological Discrimination -- 5. Models in the Environment Sciences -- 5.1 Probability Laws for Topological Properties of Drainage Basins -- 5.2 Indices and Models for Aggregation in Spatial Patterns --
5.3 Extreme Order Statistics in Large Samples from Exponential Type Distributions and Their Application to Fire Loss -- 5.4 Statistical Distributions in Forestry and Forest Products Research -- 6. A Modern Course on Statistical
Distributions -- 6.1 Introduction and Discussion
ISBN:9789401018456
Series:eBooks
Series:SpringerLink (Online service)
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Series:NATO Advanced Study Institutes Series, Series C — Mathematical and Physical Sciences: 17
Keywords: Mathematics , Applied mathematics , Engineering mathematics , Mathematics , Applications of Mathematics
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Call number:SPRINGER-1975-9781468428599:ONLINE Show nearby items on shelf
Title:Behavioral Toxicology
Author(s):
Date:1975
Size:1 online resource (469 p.)
Note:10.1007/978-1-4684-2859-9
Contents:1 Carbon Monoxide and Human Functions -- Background -- Recent Work in our Laboratory -- Discussion -- Summary -- Acknowledgments -- References -- General Discussion -- 2 The Effect of Carbon Monoxide on Time Perception, Manual
Coordination, Inspection, and Arithmetic -- Experimental Method -- Results -- Discussion -- Summary -- References -- General Discussion -- 3 Preliminary Studies of the Effects of Carbon Monoxide on Vigilance in Man -- Method -- Results
-- Discussion -- Summary -- References -- General Discussion -- 4 Carbon Monoxide and Human Performance: A Methodological Exploration -- Method -- Experiment I. Simultaneous Digit-Processing and Peripheral Detection -- Experiment II.
The Rate Threshold of Blocking -- Experiment III. Simultaneous Digit-Processing and Double-Jump Detection -- Experiment IV. Effects of Carbon Monoxide on Eye Movements and Monitoring Performance -- Experiment V. Effects of Carbon
Monoxide on Self-Paced Digit Keying -- Concluding Remarks -- Summary -- Acknowledgments -- References -- General Discussion -- 5 The Comparative Effects of Hypoxic and Carbon Monoxide Hypoxia on Behavior -- Procedures -- Hypoxia --
Carbon Monoxide -- References -- General Discussion -- 6 The Application of a Computer-Controlled Time Discrimination Performance to Problems in Behavioral Toxicology -- Methods and Materials -- Time Discrimination Thresholds --
Effects of Chorpromazine on Time Discrimination -- Effects of Carbon Monoxide on Time Discrimination -- Summary -- Acknowledgments -- References -- General Discussion -- 7 Behavioral Toxicity of Anticholinesterase Agents:
Methodological, Neurochemical, and Neuropsychological Aspects -- Materials and Methods -- Acute Anticholinesterase Effects -- Subacute and Chronic Anticholinesterase Effects -- Possible Central Actions of Enzyme Reactivations --
Cholinergic Systems and Behavior -- Human Anticholinesterase Intoxication -- General Discussion and Conclusions -- Summary -- Acknowledgments -- References -- General Discussion -- 8 Behavioral Toxicologic Studies of Dieldrin, DDT, and
Ruelene in Sheep -- Method -- Results -- Discussion -- Summary -- Acknowledgments -- References -- General Discussion -- 9 Use of Behavioral Techniques in the Assessment of Environmental Contaminants -- Pertinent Literature -- Lashley
III Maze -- Fixed Interval Operant Conditioning -- DRL Operant Conditioning -- Behavioral Research Interface -- References -- General Discussion -- 10 Utilities and Limitations of Behavioral Techniques in Industrial Toxicology -- The
Determination of Behavioral Performance Decrement during Inhalation Exposure to Halogenated Solvents -- The Complementarity of Behavioral and Pathological Methodology in the Toxicology of a New Compound -- The Problems and Significance
of Individual Differences in Behavioral Toxicology -- Conclusions -- Technical Appendix -- References -- General Discussion -- 11 Effects of the Inhalation of Cigarette Smoke on Swimming Endurance and Avoidance Behavior in the Rat --
The Inhalation Technique -- The Effects on Swimming Endurance -- Effects on Avoidance Behavior Under Extinction Procedure -- Discussion -- Summary -- References -- General Discussion -- 12 Behavioral Teratology and Toxicology -- Basic
Considerations in Behavioral Teratology -- Subtle and Long-Term Consequences of Prenatal Exposure to Methylmercury -- Summary -- References -- General Discussion -- 13 Effects of Drugs on Schedule-Controlled Behavior and Cardiovascular
Function in the Squirrel Monkey -- Effects of Drugs on Schedule-Controlled Behavior -- Cardiovascular Changes Associated with Schedule-Controlled Behavior -- Measurements of Blood Pressure and Heart Rate -- Changes in Blood Pressure
and Heart Rate Under Fixed-Ratio Schedules -- Effects of Drugs on Cardiovascular Function during Behavioral Experiments -- Acknowledgment -- References -- General Discussion -- 14 Behavioral, Biochemical, and Morphological Effects of
Methamphetamine in the Rhesus Monkey -- General Methodology -- The Acute Lethal Dose of Intravenous Methamphetamine -- Acute Effects of Methamphetamine on Food- and Water-Reinforced Fixed-Ratio Behavior -- Chronic Effects of
Methamphetamine on Food-Reinforced Fixed-Ratio Behavior -- The Effects of Methamphetamine on DRL Performance -- Biochemical and Morphological Effects of Chronic Methamphetamine -- Conclusions -- References -- General Discussion -- 15
Behavioral Assessment of Ototoxicity in Nonhuman Primates -- Method -- Results -- Summary -- Acknowledgment -- References -- General Discussion -- 16 Quantitative Perspectives on the Long-Term Toxicity of Methylmercury and Similar
Poisons -- 17 An Overview of Behavioral Toxicology -- Author Index
ISBN:9781468428599
Series:eBooks
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Series:Springer eBooks
Series:Environmental Science Research : 5
Keywords: Environment , Air pollution , Environment , Atmospheric Protection/Air Quality Control/Air Pollution
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Call number:SPRINGER-1975-9781468426342:ONLINE Show nearby items on shelf
Title:Behavioral Pharmacology The Current Status
Author(s):
Date:1975
Size:1 online resource (301 p.)
Note:10.1007/978-1-4684-2634-2
Contents:The future of behavioral pharmacology -- Session I Environmental Influences Affecting the Voluntary Intake of Drugs -- Environmental influences affecting the voluntary intake of drugs: an overview -- An experimental analysis of
behavioral factors in drug dependence -- Second-order schedules of drug injection -- Behavioral functions of narcotic antagonists: response-drug contingencies -- Experimental models for the modification of human drug
self-administration: Methodological developments in the study of ethanol self-administration by alcoholics -- Session II Interactions of Behavioral and Neurochemical Processes -- On neurochemistry and behavior -- Behavioral correlates
of serotonin depletion -- Neurochemical changes associated with schedule-controlled behavior -- Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior -- Catecholamines and drug—behavior
interactions -- Session III Behavioral Toxicology -- Behavioral toxicology: A developing discipline -- Assessing the impact of low level chemicals on development: behavioral and latent effects -- Amphetamine toxicity: behavioral and
neuropathological indexes -- Psychophysical evaluation of toxic effects on sensory systems -- Behavioral effects of mercury and methylmercury -- Session IV Contingencies of Reinforcement as Determinants of Drug Response --
Schedule-controlled behaviors as determinants of drug response -- Determinants of drug effects on punished responding -- The role of discriminative stimuli in modulating drug action -- Reinforcement schedules and extrapolations to
humans from animals in behavioral pharmacology -- Discrete trial analysis of drug action
ISBN:9781468426342
Series:eBooks
Series:SpringerLink (Online service)
Series:Springer eBooks
Series:FASEB Monographs : 4
Keywords: Medicine , Pharmacology , Behavioral sciences , Biomedicine , Pharmacology/Toxicology , Behavioral Sciences
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Call number:RA776.5.H67::2006 Show nearby items on shelf
Title:Living Green : A Practical Guide to Simple Sustainability
Author(s): Greg Horn
Date:2006
Publisher:Freedom Press
ISBN:1893910474
Keywords: Health Behavior , conservation of Natural Resources , Housing , Consumer goods, Toxicology , Housing and health , Environmental protection, Citizen participation
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Call number:RA1242.P7P28::1983 Show nearby items on shelf
Title:PCBs, human and environmental hazards
Conference:International Symposium on PCBs in the Great Lakes, Michigan State University, 1982
Author(s): Frank M. D'Itri
Date:1983
Publisher:Butterworth Publishers, Boston
Size:443
ISBN:0250405989
Keywords: Polychlorinated biphenyls Toxicology
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Call number:RA1231.R2P277 Show nearby items on shelf
Title:Accelerator health physics
Author(s): H.Wade Patterson
Ralph H. Thomas
Date:1973
Publisher:Academic Press, New York
Size:668
ISBN:0125471505
Keywords: Radiation Toxicology.
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Cover Image This book is only available through interlibrary loan. (email library@fnal.gov if you would like this title added to the Library collection.)
Call number:RA1231.R2N26::1979 Show nearby items on shelf
Title:Management of persons accidentally contaminated with radionuclides : recommendations of the National Council on Radiation Protection and Measurements.
Author(s): National Council on Radiation Protection and Measurements
Date:1980
Publisher:NCRP, Washington, D.C
Size:205
ISBN:0913392499
Series:NCRP report : no. 65 v. 52, nos. 1-4
Keywords: Radioactive substances Toxicology.
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Call number:RA1231.R2H396 Show nearby items on shelf
Title:Fundamentals of radiation protection
Author(s): Hugh F. Henry 1916-
Date:1969
Publisher:Wiley-Interscience, New York
Size:485
ISBN:0471372943
Keywords: Radiation Toxicology.
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Call number:RA1231.R2H34 Show nearby items on shelf
Title:Health physics operational monitoring. Editors: Charles A. Willis [and] John S. Handloser.
Author(s): Charles A. Willis
Date:1972
Publisher:Gordon and Breach, New York
Size:31848
ISBN:0677136706
Keywords: Radiation Toxicology
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Call number:RA1231.R2C67::2008 Show nearby items on shelf
Title:Topics in Accelerator Health Physics: HPS January 2008 Professional Development School Proceedings
Conference:Health Physics Society HPS 2008 Professional Development School: Topics In Accelerator Health Physics, 31 Jan - 2 Feb 2008, Oakland, California
[C08-01-31]
Author(s): J. Donald Cossairt (ed.)
Vaclav Vylet (ed.)
John W. Edwards (ed.)
Date:2008
Publisher:Medical Physics Publishing
Keywords: Radiation Toxicology
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Call number:RA1231.R2C332::1976 Show nearby items on shelf
Title:Introduction to health physics.
Author(s): Herman Cember
Date:1976
Edition:[2nd ed.]
Publisher:Pergamon Press, Oxford
Size:420
Keywords: Radiation Toxicology.
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Call number:RA1231.M52IZ7 Show nearby items on shelf
Title:Toxicology of the rare metals. (Toksikologiya redkikh metallov). Z. I. Izraelson, editor. Translated from Russian [by Y. Halperin]
Author(s): Z.I. Izraelson
Date:1967
Publisher:Israel Program for Scientific Translations, [available from the Dept. of Commerce, Clearinghouse for Federal Scientific and Technical Information, Springfield, Va, Jerusalem
Size:234
Series:AEC-tr-6710 no. 15
Keywords: Metals Toxicology.
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Location: MAIN
Report-number:AEC-tr-6710

Cover Image This book is only available through interlibrary loan. (email library@fnal.gov if you would like this title added to the Library collection.)
Call number:RA1211.C296::1986 Show nearby items on shelf
Title:Casarett and Doull's toxicology : the basic science of poisons
Author(s): Louis J. Casarett
John Doull
Date:1986
Edition:3rd ed.
Publisher:Macmillan, New York
Size:974
ISBN:0023646500
Keywords: Toxicology.
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Location: ILL

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Call number:QC454.M3W48::1986 Show nearby items on shelf
Title:Mass spectrometry : applications in science and engineering
Author(s): Frederick Andrew White 1918-
George M.(Marshall) Wood 1933-
Date:1986
Publisher:John Wiley and Sons: New York
Size:773 pgs.
Contents:Part I: Instrumentation - 1. Introduction: Atoms, Molecules, Ions, and Isotopes, 2. Ion Sources, 3. Types of Spectrometers, 4. Tandem Systems and Special Types, 5. Detection of ion Beams, 6. Computer-Aided Data Processing, 7. Chromatography / Mass Spectrometry
Part II: Engineering and the Physical Sciences - 8. Geochemistry and Geochronology, 9. Atmospheric, Lunar, and Planetary Measurements, 10. Metals, Glasses, Ceramics, and Composites, 11. Electronic Materials and Devices, 12. Electrophysics, 13. Energy System Diagnostics: Solar, Fossil, Fission, Fusion, 14. On-Line Monitoring and Process Control
Part III: Environmental Measurements and the Life Sciences - 15. Air and Water Monitoring, 16. Agriculture and Food Science, 17. Beomedical Applications, 18. Pharmacology, 19. Toxicology and Forensic Science, 20. New Frontiers in Mass Spectrometry and Ion Beam Technology
Appendices: 1. Isotopic Abundances of the Elements, 2. Ionization Potentials, Electron Affinities, Work Functions, and Melting Points
ISBN:0471092363
Keywords: Mass spectrometry.
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Call number:APCPC:V1326 Show nearby items on shelf
Title:BIOLOGY, NANOTECHNOLOGY, TOXICOLOGY, AND APPLICATIONS Proceedings of the 5th BioNanoTox and Applications International Research Conference
Author(s): Olga Tarasenko
Parimal Chowdhury
Michael Soulsby
Alexei Basnakian
Rahul Mehta
Islam Khan
Nawab Ali
Pierre Alusta
Date:2011
Publisher:AIP Publishing
Note:AIP Conference Proceedings eBook platform
ISBN:9780735409064
Series:AIP Conference Proceedings v.1326
Series:e-Books
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Call number:APCPC:V1229 Show nearby items on shelf
Title:BIOLOGY, NANOTECHNOLOGY, TOXICOLOGY AND APPLICATIONS 4th BioNanoTox (Biology, Nanotechnology, Toxicology) and Applications
Author(s): Olga Tarasenko
Date:2010
Publisher:AIP Publishing
Note:AIP Conference Proceedings eBook platform
ISBN:9780735407732
Series:AIP Conference Proceedings v.1229
Series:e-Books
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Location: ONLINE

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Call number:ACGIH-TLV::2005 Show nearby items on shelf
Title:2005 TLVs and BEIs : threshold limit values for chemical substances and physical agents : biological exposure indices
Author(s):
Date:2005
Publisher:ACGIH Worldwide, Cincinnati, OH
ISBN:1882417585
Series:WorkSmart Standard
Keywords: Biological exposure indices (Industrial toxicology)
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Location: STANDARDS

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